Oocyte Cryopreservation: Retrospective Analysis of 5 Years
Experience

Ozmen, Batuhan; türkyılmaz, esengül; Doğan Durdağ, Gülşen; Atabekoğlu, Cem Somer; Sönmezer, Murat; Göktepe, Halime

Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience

Halime GÖKTEPE, (Department of Gynecology and Obstetrics, Konya Education and Research Hospital, Konya, Turkey)

Esengül TÜRKYILMAZ, (Department of Gynecology and Obstetrics, Ankara City Hospital, Ankara, Turkey)

Gülşen Doğan DURDAĞ, (Department of Gynecology and Obstetrics, Baskent University, Faculty of Medicine, Adana, Turkey)

Murat SONMEZER, (Department of Gynecology and Obstetrics, Ankara University, Faculty of Medicine, Ankara, Turkey)

Cem Somer ATABEKOĞLU, (Department of Gynecology and Obstetrics, Ankara University, Faculty of Medicine, Ankara, Turkey)

Batuhan ÖZMEN (Department of Gynecology and Obstetrics, Ankara University, Faculty of Medicine, Ankara, Turkey)

GORM:Gynecology Obstetrics & Reproductive Medicine

8 2

Yıl: 2021 Cilt: 27 Sayı: 3 Sayfa Aralığı: 248 - 253 Metin Dili: İngilizce İndeks Tarihi: 29-05-2022

Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience

Öz:

OBJECTIVE: To analyze demographic and clinical data of patients who resorted to oocyte freezing between January 2014 and December 2018. STUDY DESIGN: Patients who applied to the Reproductive Endocrinology and Infertility Unit of Ankara University School of Medicine between January 2014 and December 2018 with the request of oocyte freezing were included in this study. The files and computer records of the patients were analyzed retrospectively and sociodemographic, clinical and laboratory data were evaluated. RESULTS: A total of 46 cycles were recorded in 40 patients over a 5-year period. The main indications were low ovarian reserve and/or advanced age (68.3%) and malignancy diagnosis (31.7%). There was a significant difference between elective fertility preservation and oncofertility preservation (Onco-FP) groups in terms of the age (38.4±4.7 vs 28.4±6.1; p=0.001). There was a significant difference between two groups in favor of oncofertility group in terms of anti-Mullerian hormone level, basal follicle-stimulating hormone level, antral follicle count, trigger day estradiol (E2) level, number of obtained oocytes, MII oocytes, and frozen oocytes CONCLUSION: According to our study, the most prominent oocyte cryopreservation indication was advanced age and/or low ovarian reserve. The number of oocytes collected from patients in the Onco-FP group and thus the number of frozen oocytes was significantly higher than in the elective fertility preservation group, due to younger ages and better ovarian reserve in the Onco-FP group. Abdominal administration of the technique is particularly important for virgin patients in our country. Oocyte freezing is a fertility protection method available in a wide range of indications for reproductive-aged women.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Schattman GL. Clinical practice. Cryopreservation of oocytes. N Engl J Med. 2015;373(18):1755-60. Doi: 10.1056/NEJMcp1307341.
2. Danis RB, Pereira N, Elias RT. Random start ovarian stimulation for oocyte or embryo cryopreservation in women desiring fertility preservation prior to gonadotoxic cancer therapy. Curr Pharm Biotechnol. 2017;18(8):609- 13. Doi:10.2174/1389201018666170808122531.
3. https://www.resmigazete.gov.tr/eskiler/2014/09/20140930 -4.htm. Sayı 29135/sayfa 18.
4. Pennings G. What are the ownership rights for gametes and embryos? Advance directives and the disposition of cryopreserved gametes and embryos. Hum Reprod. 2000; 15(5):979-86. Doi:10.1093/humrep/15.5.979.
5. de Jong A, Dondorp WJ, de Wert GM. The scope of prenatal diagnostic testing for chromosomal aberrations: broad or narrow? Ethical considerations on the choice of tests. Ned Tijdschr Geneeskd. 2009;153:A1060. PMID: 20015413.
6. Goold I, Savulescu J. In favour of freezing eggs for nonmedical reasons. Bioethics. 2009;23(1):47-58. Doi:10. 1111/j.1467-8519.2008.00679.x.
7. Rivas Leonel EC, Lucci CM, Amorim CA. Cryopreservation of human ovarian tissue: a review. Transfus Med Hemother. 2019;46(3):173-81. Doi:10. 1159/000499054.
8. Practice Committees of American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. Mature oocyte cryopreservation: a guideline. Fertil Steril. 2013; 99(1):37-43. Doi:10. 1016/j.fertnstert.2012.09.028.
9. Chen C. Pregnancy after human oocyte cryopreservation. Lancet. 1986;1(8486):884-6. Doi:10.1016/s0140-6736 (86)90989-x.
10. Bernard A, Fuller BJ. Cryopreservation of human oocytes: current problems and perspectives. Hum Reprod. 1996;2 (3):193-207. Doi:10.1093/humupd/2.3.193.
11. Vincent C, Pickering SJ, Johnson MH. The hardening effect of dimethylsulphoxide on the mouse zona pellucida requires the presence of an oocyte and is associated with a reduction in the number of cortical granules present. J Reprod Fertil. 1990;89(1):253-9. Doi:10.1530/jrf.0. 0890253.
12. Kuleshova L, Gianaroli L, Magli C, Ferraretti A, Trounson A. Birth following vitrification of a small number of human oocytes: case report. Hum Reprod. 1999;14(12): 3077-9. Doi:10.1093/humrep/14.12.3077.
13. Smith GD, Serafini PC, Fioravanti J, Yadid I, Coslovsky M, Hassun P, et al. Prospective randomized comparison of human oocyte cryopreservation with slow-rate freezing or vitrification. Fertil Steril. 2010;94(6):2088-95. Doi:10. 1016/j.fertnstert.2009.12.065
14. Rudick B, Opper N, Paulson R, Bendikson K, Chung K. The status of oocyte cryopreservation in the United States. Fertil Steril. 2010;94(7):2642-6. Doi: 10.1016/j.fertnstert. 2010.04.079.
15. Chian RC, Huang JY, Tan SL, Lucena E, Saa A, Rojas A, et al. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reprod Biomed Online. 2008;16(5):608-10. Doi:10.1016/s1472-6483(10)60471-3.
16. Şükür YE, Özmen B, Özdemir ED, Seval MM, Kalafat E, Sönmezer M, et al. Final oocyte maturation with two different GnRH agonists in antagonist co-treated cycles at risk of ovarian hyperstimulation syndrome. Reprod Biomed Online. 2018; 25(12):1649-54. Doi:10.1016/j. rbmo.2016.10.004.
17. Cobo A, García-Velasco JA, Coello A, Domingo J, Pellicer A, Remohí J. Oocyte vitrification as an efficient option for elective fertility preservation. Fertil Steril. 2016;105(3):755-764.e8. Doi:10.1016/j.fertnstert.2015. 11.027.
18. Kim J, Oktay K, Gracia C, Lee S, Morse C, Mersereau JE. Which patients pursue fertility preservation treatments? A multicenter analysis of the predictors of fertility preservation in women with breast cancer. Fertil Steril. 2012;97 (3):671-6. Doi:10.1016/j.fertnstert.2011.12.008.
19. Garcia-Velasco JA, Domingo J, Cobo A, Martínez M, Carmona L, Pellicer A. Five years' experience using oocyte vitrification to preserve fertility for medical and nonmedical indications. Fertil Steril. 2013;99(7):1994-9. Doi:10.1016/j.fertnstert.2013.02.004.
20. Cobo A, García-Velasco J, Domingo J, Pellicer A, Remohí J. Elective and Oncofertility preservation: factors related to IVF outcomes. Hum Reprod. 2018;33(12): 2222-31. Doi: 10.1093/humrep/dey321.
21. Dolinko AV, Farland LV, Missmer SA, Srouji SS, Racowsky C, Ginsburg ES. Responses to fertility treatment among patients with cancer: a retrospective cohort study. Fertil Res Pract. 2018;4:3. Doi:10.1186/s40738- 018-0048-2.
22. Cil AP, Bang H, Oktay K. Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis. Fertil Steril. 2013;100(2):492-9.e3. Doi:10.1016/j.fertnstert.2013.04.023.
23. Iussig B, Maggiulli R, Fabozzi G, Bertelle S, Vaiarelli A, Cimadomo D, et al. A brief history of oocyte cryopreservation: arguments and facts. Acta Obstet Gynecol Scand. 2019;98(5):550-8. Doi:10.1111/aogs.13569.
24. Drakopoulos P, Blockeel C, Stoop D, Camus M, de Vos M, Tournaye H, et al. Conventional ovarian stimulation and single embryo transfer for IVF/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos? Hum Reprod. 2016;31(2):370-6. Doi:10.1093/humrep/ dev316.
25. Devesa M, Tur R, Rodriguez I, Coroleu B, Martinez F, Polyzos NP. Cumulative live birth rates and number of oocytes retrieved in women of advanced age. A single centre analysis including 4500 women >/=38 years old. Hum Reprod. 2018;33(11):2010-7. Doi:10.1093/humrep/ dey295.
26. Wennberg AL, Schildauer K, Brännström M. Elective oocyte freezing for nonmedical reasons: a 6-year report on utilization and in vitro fertilization results from a Swedish center. Acta Obstet Gynecol Scand. 2019;98(11):1429-34. Doi:10.1111/aogs.13673.
27. Bachmann G, MacArthur TA, Khanuja K. Need for comprehensive counseling in women requesting oocyte cryopreservation. J Womens Health (Larchmt). 2018;27(3): 227-30. Doi:10.1089/jwh.2017.6423.

APA	Göktepe H, türkyılmaz e, Doğan Durdağ G, Sönmezer M, Atabekoğlu C, Ozmen B (2021). Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. , 248 - 253.
Chicago	Göktepe Halime,türkyılmaz esengül,Doğan Durdağ Gülşen,Sönmezer Murat,Atabekoğlu Cem Somer,Ozmen Batuhan Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. (2021): 248 - 253.
MLA	Göktepe Halime,türkyılmaz esengül,Doğan Durdağ Gülşen,Sönmezer Murat,Atabekoğlu Cem Somer,Ozmen Batuhan Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. , 2021, ss.248 - 253.
AMA	Göktepe H,türkyılmaz e,Doğan Durdağ G,Sönmezer M,Atabekoğlu C,Ozmen B Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. . 2021; 248 - 253.
Vancouver	Göktepe H,türkyılmaz e,Doğan Durdağ G,Sönmezer M,Atabekoğlu C,Ozmen B Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. . 2021; 248 - 253.
IEEE	Göktepe H,türkyılmaz e,Doğan Durdağ G,Sönmezer M,Atabekoğlu C,Ozmen B "Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience." , ss.248 - 253, 2021.
ISNAD	Göktepe, Halime vd. "Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience". (2021), 248-253.

APA	Göktepe H, türkyılmaz e, Doğan Durdağ G, Sönmezer M, Atabekoğlu C, Ozmen B (2021). Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. GORM:Gynecology Obstetrics & Reproductive Medicine, 27(3), 248 - 253.
Chicago	Göktepe Halime,türkyılmaz esengül,Doğan Durdağ Gülşen,Sönmezer Murat,Atabekoğlu Cem Somer,Ozmen Batuhan Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. GORM:Gynecology Obstetrics & Reproductive Medicine 27, no.3 (2021): 248 - 253.
MLA	Göktepe Halime,türkyılmaz esengül,Doğan Durdağ Gülşen,Sönmezer Murat,Atabekoğlu Cem Somer,Ozmen Batuhan Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.27, no.3, 2021, ss.248 - 253.
AMA	Göktepe H,türkyılmaz e,Doğan Durdağ G,Sönmezer M,Atabekoğlu C,Ozmen B Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. GORM:Gynecology Obstetrics & Reproductive Medicine. 2021; 27(3): 248 - 253.
Vancouver	Göktepe H,türkyılmaz e,Doğan Durdağ G,Sönmezer M,Atabekoğlu C,Ozmen B Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience. GORM:Gynecology Obstetrics & Reproductive Medicine. 2021; 27(3): 248 - 253.
IEEE	Göktepe H,türkyılmaz e,Doğan Durdağ G,Sönmezer M,Atabekoğlu C,Ozmen B "Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience." GORM:Gynecology Obstetrics & Reproductive Medicine, 27, ss.248 - 253, 2021.
ISNAD	Göktepe, Halime vd. "Oocyte Cryopreservation: Retrospective Analysis of 5 Years Experience". GORM:Gynecology Obstetrics & Reproductive Medicine 27/3 (2021), 248-253.