TY  - JOUR
TI  - Prognostic and Predictive Significance of PD-L1
Expression in Non-Small Cell Lung Cancer Patients:
A Single-Center Experience
AB  - Objective: To investigate the prognostic and predictive value of PD-L1 expression in operated non-small cell lung cancer (NSCLC) patients and
to analyze its relationship with clinicopathological factors.
Material and Method: A total of 90 patients with operable NSCLC were included in this retrospective single center study. Tumor blocks of
patients were stained immunohistochemically with PD-L1 polyclonal antibody. When evaluated immunohistochemically and statistically,
patients with tumor staining percentage of ≥5%, those with +2 and +3 membranous staining intensity, and those with ≥50% H-Score were
considered positive. The relationship between PD-L1 expression status and clinicopathological features in addition to the prognostic effect of
PD-L1 on survival were statistically analyzed.
Results: The frequency of PD-L1 expression was 37%, 15% and 5% according to the staining percentage, staining intensity, and the H-Score,
respectively. There was no significant relationship between PD-L1 expression and age, gender, smoking, tumor stage and histological subtype
(p> 0.05). However, PD-L1 expression was relatively higher in patients <65 years of age, men, smokers, patients with advanced tumor stage, and
squamous cell subtype. Based on the analysis of the H-Score, no significant difference was noted regarding disease-free survival time between
PD-L1 positive and PD-L1 negative patients (median 20 [95% CI 1.2-38.7] months vs. median 27 [95% CI 17.5-36] months, p=0.208). However,
overall survival time was significantly shorter in PD-L1 positive compared to PD-L1 negative patients (median 24 months [95% CI 9.9-38] vs.
median 48 months [95% CI 33.6-62.3], p=0.049).
Conclusion: In patients with high PD-L1 expression, the biological behavior of the cancer was more aggressive, and the life expectancy was
shorter. PD-L1 expression seems to be a poor prognostic marker in NSCLC patients.
AU  - OZKAN, Metin
AU  - AYTEKIN, Aydın
AU  - ARAK, HACI
AU  - CANOZ, Ozlem
DO  - 10.5146/tjpath.2021.01545
PY  - 2021
JO  - Türk Patoloji Dergisi
VL  - 37
IS  - 3
SN  - 1018-5615
SP  - 239
EP  - 248
DB  - TRDizin
UR  - http://search/yayin/detay/510970
ER  -