Objective: To define the relationship between cystoscopic findings, including novel findings such as the hypervascularization, of bladder pain syndrome/interstitial cystitis (BPS/IC) and the response to intravesical therapy. Material and methods: We retrospectively evaluated cystoscopy findings in patients who had a preliminary diagnosis of BPS/IC. All patients received early intravesical combined therapy (ICT), ie, within 2 hours after hydrodistention. Additionally, ICT was continued according to our protocol. Cystoscopic findings were classi- fied as glomerulations, hypervascularization, and Hunner’s lesion (HL). The therapy responses were evaluated at 1st, 3rd, 6th, and 12th months using the visual analog scale (VAS), O’Leary/Sant interstitial cystitis symp- tom index (ICSI), and interstitial cystitis problem index (ICPI) scores. Results: Out of 61 patients, HL was diagnosed during cystoscopy in six (9.8%) patients, glomerulations in 35 (57.4%) patients, and hypervascularization in 15 (24.6%) patients. No pathological findings were defined in five (8.2%) patients. In the glomerulation and hypervascularization group, the median VAS, ICSI, and ICPI scores were lower than those in the preoperative period in the follow-up. In patients with HL, the median VAS scores were lower in the entire follow-up compared to the preoperative period, with an increase at 1st year compared to 6th month, and ICSI scores were lower than preoperative period in the entire follow-up, with an increase at 3rd month and 1st year. ICPI scores were also lower during the follow-up, with an increase observed in the 1st year. Conclusion: The presence of hypervascularization should be defined since it might show different characteris- tics that may affect the ICT response. Patients with glomerulations might be good candidates for early com- bined intravesical therapy.