TY  - JOUR
TI  - Effect of focal and diffuse hypervascularization as cystoscopic
findings on predicting intravesical therapy response in patients
with bladder pain syndrome
AB  - Objective: To define the relationship between cystoscopic findings, including novel findings such as the
hypervascularization, of bladder pain syndrome/interstitial cystitis (BPS/IC) and the response to intravesical
therapy.
Material and methods: We retrospectively evaluated cystoscopy findings in patients who had a preliminary
diagnosis of BPS/IC. All patients received early intravesical combined therapy (ICT), ie, within 2 hours after
hydrodistention. Additionally, ICT was continued according to our protocol. Cystoscopic findings were classi-
fied as glomerulations, hypervascularization, and Hunner’s lesion (HL). The therapy responses were evaluated
at 1st, 3rd, 6th, and 12th months using the visual analog scale (VAS), O’Leary/Sant interstitial cystitis symp-
tom index (ICSI), and interstitial cystitis problem index (ICPI) scores.
Results: Out of 61 patients, HL was diagnosed during cystoscopy in six (9.8%) patients, glomerulations in 35
(57.4%) patients, and hypervascularization in 15 (24.6%) patients. No pathological findings were defined in
five (8.2%) patients. In the glomerulation and hypervascularization group, the median VAS, ICSI, and ICPI
scores were lower than those in the preoperative period in the follow-up. In patients with HL, the median
VAS scores were lower in the entire follow-up compared to the preoperative period, with an increase at 1st
year compared to 6th month, and ICSI scores were lower than preoperative period in the entire follow-up,
with an increase at 3rd month and 1st year. ICPI scores were also lower during the follow-up, with an increase
observed in the 1st year.
Conclusion: The presence of hypervascularization should be defined since it might show different characteris-
tics that may affect the ICT response. Patients with glomerulations might be good candidates for early com-
bined intravesical therapy.
AU  - Danacioglu, Yavuz Onur
AU  - Onur, Rahmi
AU  - EFİLOGLU, Ozgur
AU  - KESER, Ferhat
AU  - EROL, Bulent
AU  - KAZAN, Huseyin Ozgur
DO  - 10.5152/tju.2021.21093
PY  - 2021
JO  - Turkish Journal of Urology
VL  - 47
IS  - 4
SN  - 2149-3235
SP  - 325
EP  - 337
DB  - TRDizin
UR  - http://search/yayin/detay/510977
ER  -