TY  - JOUR
TI  - Comparison of the effectiveness of high-flow
and conventional nasal cannula oxygen therapy
in pulmonary embolism patients with acute
hypoxemic respiratory failure
AB  - Comparison of the effectiveness of high-flow and conventional nasal
cannula oxygen therapy in pulmonary embolism patients with acute
hypoxemic respiratory failure
Introduction: The leading cause of mortality in pulmonary embolism (PE) is
hypoxemic respiratory failure. The aim of this study was to compare the efficacy of high-flow nasal cannula (HFNC) and conventional nasal cannula
(CNC) oxygen therapy in PE patients with hypoxemia.
Materials and Methods: Fifty-eight patients with a PaO2/FIO2 ratio below 300
who were admitted to the emergency department with acute respiratory distress and followed up in our intensive care unit due to PE between March and
October 2019 were included in the study. One group (n= 29) received HFNC
oxygen therapy and the other group (n= 29) received CNC oxygen therapy.
Results: Arterial blood gas analysis showed no significant differences in baseline SpO2 and PaO2 between the HFNC and CNC groups, whereas both values
were significantly higher in the HFNC group starting at 1 hour (PaO2: p= .01,
p= .001, p= .001; SpO2: p= .009, p= .005, p= .002). Among massive PE patients with contraindications for thrombolytic therapy, there was no significant
difference between the HFNC and CNC groups in baseline SpO2, PaO2, or
respiratory rate, but those who received HFNC therapy had significant higher
SpO2 starting at 15 minutes (p= .004 for all), significantly higher PaO2 starting
at 1 hour (p= .01, p= .001, p= .001), and significantly lower respiratory rate
starting at 30 minutes (p= .003, p= .001, p= .001, p= .002, p= .002).
Conclusion: In patients presenting with PE and hypoxemic respiratory failure,
HFNC oxygen therapy was more effective on both vital signs and arterial
blood gas parameters compared to conventional oxygen therapy and can be
used safely as primary treatment
AU  - Yilmazel Ucar, Elif
AU  - Kerget, Bugra
AU  - SAGLAM, Leyla
AU  - Aksakal, Alperen
DO  - 10.5578/tt.20219604
PY  - 2021
JO  - Tüberküloz ve Toraks
VL  - 69
IS  - 4
SN  - 0494-1373
SP  - 469
EP  - 476
DB  - TRDizin
UR  - http://search/yayin/detay/511012
ER  -