TY  - JOUR
TI  - Protective Effects of Oxytocin and Progesterone on Paclitaxel-induced
Neuropathy in Rats
AB  - Objective: Paclitaxel (Ptx), used to treat cancer, still causes neuropathic pain and
peripheral neuropathy today. This study was conducted to evaluate the effects
of progesterone (Pg) and oxytocin (Oxy) on peripheral neuropathy rat model
induced by Ptx. Materials and Methods: A total of 38 male Sprague–Dawley
rats were randomly divided into five groups, e.g., control (n = 6), Ptx (n = 8),
Ptx + Oxy (n = 8), Ptx + Pg (n = 8), and Ptx + Oxy + Pg (n = 8). The rats were
monitored daily for body weight change throughout the experiment. To evaluate
peripheral neuropathy, electroneuromyography measurements (latency, amplitude,
and motor nerve conduction velocity (MNCV)) were recorded from the sciatic
nerve innervating the gastrocnemius muscle. Sciatic nerve tissue samples were
collected for histopathological evaluation. Results: Ptx led to significant reductions
in body weight from day 6 (P < 0.05). There was no difference between groups
in the distal latency and amplitudes (P > 0.05). Proximal latency was prolonged
in Ptx group rats than in other groups (P < 0.05). Importantly, it was found that
MNCV was higher in the Ptx + Pg group than Ptx, Ptx + Oxy, and Ptx + Oxy + Pg
groups (P < 0.05). Furthermore, Pg‑administered rats had the lowest nerve
degeneration compared to rats administered Oxy and Oxy + Pg (P < 0.05).
Conclusions: The present findings suggest that Pg has a protective effect on
peripheral neuropathy induced by Ptx in rat.
AU  - Balkaya, Muharrem
AU  - EKİCİ, Mehmet
DO  - 10.4103/nsn.nsn_113_21
PY  - 2021
JO  - Neurological sciences and neurophysiology (Online)
VL  - 38
IS  - 4
SN  - 2636-865X
SP  - 262
EP  - 270
DB  - TRDizin
UR  - http://search/yayin/detay/511734
ER  -