Long-Term Surgical Outcomes and Predictors of Surgical Treatment in
Temporal Lobe Epilepsy

yıldırım, İrem; Bilir, Erhan; GÜRSES, Aslı AKYOL; ATAOĞLU, Esra ERKOÇ; ATAY, Lütfiye Özlem; HİRFANOĞLU, Tuğba; ONER, Ali Yusuf; SERDAROĞLU, Ayşe; KURT, Gökhan; AKDEMİR, Ümit Özgür

doi:10.4103/nsn.nsn_200_21

Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy

İrem YILDIRIM, (Gazi Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Ankara, Türkiye)

Aslı AKYOL GÜRSES, (Gazi Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Ankara, Türkiye)

Esra ERKOÇ ATAOĞLU, (Gazi Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Ankara, Türkiye)

Erhan BİLİR, (Gazi Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Ankara, Türkiye)

Gökhan KURT, (Gazi Üniversitesi, Tıp Fakültesi, Beyin Cerahisi Anabilim Dalı, Ankara, Türkiye)

Ümit Özgür AKDEMİR, (Gazi Üniversitesi, Tıp Fakültesi, Nükleer Anabilim Dalı, Ankara, Türkiye)

Lütfiye Özlem ATAY, (Gazi Üniversitesi, Tıp Fakültesi, Nükleer Anabilim Dalı, Ankara, Türkiye)

Ali Yusuf ONER, (Gazi Üniversitesi, Tıp Fakültesi, Radyoloji Bölümü, Ankara, Türkiye)

Tuğba HİRFANOĞLU, (Gazi Üniversitesi, Tıp Fakültesi, Pediatrik Nöroloji Anabilim Dalı, Ankara, Türkiye)

Ayşe SERDAROĞLU (Gazi Üniversitesi, Tıp Fakültesi, Pediatrik Nöroloji Anabilim Dalı, Ankara, Türkiye)

Neurological sciences and neurophysiology (Online)

6 0

Yıl: 2021 Cilt: 38 Sayı: 4 Sayfa Aralığı: 209 - 218 Metin Dili: İngilizce DOI: 10.4103/nsn.nsn_200_21 İndeks Tarihi: 31-05-2022

Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy

Öz:

Background: Surgical treatment of epilepsy is a favored modality in the management of refractory temporal lobe epilepsy (TLE) and known to be quite effective. The aim of this study was to evaluate the long‑term outcomes in surgical treatment of TLE and to identify prognostic factors influencing postoperative seizure remission. Materials and Methods: The patients who underwent anterior temporal lobectomy (ATL) with the diagnosis of refractory TLE in our center between the years of 2006 and 2020 were included. Preoperative workup process was carried out by a multidisciplinary team and consisted of neuropsychological examination, long‑term electroencephalography, brain magnetic resonance imaging (MRI), and fluorodeoxyglucose positron emission tomography (FDG‑PET) for each patient. Postoperative assessment of seizure control was repeated every year following surgery and categorized according to Engel’s outcome classification. The predictive value of baseline demographic, clinical, laboratory, imaging, and histopathological parameters on postoperative seizure control was also evaluated. Results: One hundred and forty‑three patients who underwent ATL with the diagnosis of TLE were included. According to Engel’s classification, the seizure freedom rate was found to be 83.2% at the 2nd year, 81.3% at the 4th year, and 79.2% at the 10th year after surgery. In the univariate analysis, febrile seizure (FS) history, unilateral interictal epileptiform discharges (IEDs), hippocampal sclerosis (HS) on MRI, unilateral temporal hypometabolism (HM) on FDG‑PET, and HS in histopathology were predictors of seizure control at the postoperative 2nd and 10th years. FS history, unilateral localization of IEDs, and unilateral FDG‑PET findings of temporal HM were found to be the independent predictors of postoperative seizure control on multivariate analysis. Conclusions: In the current study, we revealed that epilepsy surgery provides effective seizure control and represents a beneficial therapeutic option in refractory TLE. Our results also suggested that FS history, unilateral IEDs, and unilateral FDG‑PET findings of temporal HM were independent predictors of seizure remission in these patients.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	yıldırım İ, GÜRSES A, ATAOĞLU E, Bilir E, KURT G, AKDEMİR Ü, ATAY L, ONER A, HİRFANOĞLU T, SERDAROĞLU A (2021). Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. , 209 - 218. 10.4103/nsn.nsn_200_21
Chicago	yıldırım İrem,GÜRSES Aslı AKYOL,ATAOĞLU Esra ERKOÇ,Bilir Erhan,KURT Gökhan,AKDEMİR Ümit Özgür,ATAY Lütfiye Özlem,ONER Ali Yusuf,HİRFANOĞLU Tuğba,SERDAROĞLU Ayşe Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. (2021): 209 - 218. 10.4103/nsn.nsn_200_21
MLA	yıldırım İrem,GÜRSES Aslı AKYOL,ATAOĞLU Esra ERKOÇ,Bilir Erhan,KURT Gökhan,AKDEMİR Ümit Özgür,ATAY Lütfiye Özlem,ONER Ali Yusuf,HİRFANOĞLU Tuğba,SERDAROĞLU Ayşe Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. , 2021, ss.209 - 218. 10.4103/nsn.nsn_200_21
AMA	yıldırım İ,GÜRSES A,ATAOĞLU E,Bilir E,KURT G,AKDEMİR Ü,ATAY L,ONER A,HİRFANOĞLU T,SERDAROĞLU A Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. . 2021; 209 - 218. 10.4103/nsn.nsn_200_21
Vancouver	yıldırım İ,GÜRSES A,ATAOĞLU E,Bilir E,KURT G,AKDEMİR Ü,ATAY L,ONER A,HİRFANOĞLU T,SERDAROĞLU A Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. . 2021; 209 - 218. 10.4103/nsn.nsn_200_21
IEEE	yıldırım İ,GÜRSES A,ATAOĞLU E,Bilir E,KURT G,AKDEMİR Ü,ATAY L,ONER A,HİRFANOĞLU T,SERDAROĞLU A "Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy." , ss.209 - 218, 2021. 10.4103/nsn.nsn_200_21
ISNAD	yıldırım, İrem vd. "Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy". (2021), 209-218. https://doi.org/10.4103/nsn.nsn_200_21

APA	yıldırım İ, GÜRSES A, ATAOĞLU E, Bilir E, KURT G, AKDEMİR Ü, ATAY L, ONER A, HİRFANOĞLU T, SERDAROĞLU A (2021). Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. Neurological sciences and neurophysiology (Online), 38(4), 209 - 218. 10.4103/nsn.nsn_200_21
Chicago	yıldırım İrem,GÜRSES Aslı AKYOL,ATAOĞLU Esra ERKOÇ,Bilir Erhan,KURT Gökhan,AKDEMİR Ümit Özgür,ATAY Lütfiye Özlem,ONER Ali Yusuf,HİRFANOĞLU Tuğba,SERDAROĞLU Ayşe Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. Neurological sciences and neurophysiology (Online) 38, no.4 (2021): 209 - 218. 10.4103/nsn.nsn_200_21
MLA	yıldırım İrem,GÜRSES Aslı AKYOL,ATAOĞLU Esra ERKOÇ,Bilir Erhan,KURT Gökhan,AKDEMİR Ümit Özgür,ATAY Lütfiye Özlem,ONER Ali Yusuf,HİRFANOĞLU Tuğba,SERDAROĞLU Ayşe Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. Neurological sciences and neurophysiology (Online), vol.38, no.4, 2021, ss.209 - 218. 10.4103/nsn.nsn_200_21
AMA	yıldırım İ,GÜRSES A,ATAOĞLU E,Bilir E,KURT G,AKDEMİR Ü,ATAY L,ONER A,HİRFANOĞLU T,SERDAROĞLU A Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. Neurological sciences and neurophysiology (Online). 2021; 38(4): 209 - 218. 10.4103/nsn.nsn_200_21
Vancouver	yıldırım İ,GÜRSES A,ATAOĞLU E,Bilir E,KURT G,AKDEMİR Ü,ATAY L,ONER A,HİRFANOĞLU T,SERDAROĞLU A Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy. Neurological sciences and neurophysiology (Online). 2021; 38(4): 209 - 218. 10.4103/nsn.nsn_200_21
IEEE	yıldırım İ,GÜRSES A,ATAOĞLU E,Bilir E,KURT G,AKDEMİR Ü,ATAY L,ONER A,HİRFANOĞLU T,SERDAROĞLU A "Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy." Neurological sciences and neurophysiology (Online), 38, ss.209 - 218, 2021. 10.4103/nsn.nsn_200_21
ISNAD	yıldırım, İrem vd. "Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy". Neurological sciences and neurophysiology (Online) 38/4 (2021), 209-218. https://doi.org/10.4103/nsn.nsn_200_21