TY  - JOUR
TI  - Real-World Data from Turkey: Is Sofosbuvir/Ledipasvir With
or Without Ribavirin Treatment for Chronic Hepatitis C
Really Effective?
AB  - Background: In this study, we aimed to investigate the efficacy and safety of sofosbuvir-based therapies in the treatment of chronic
hepatitis C in real-world clinical practice.
Methods: Data from patients with chronic hepatitis C treated with SOF/LDV ± RBV or SOF/RBV in 31 centers across Turkey between April
1, 2017, and August 31, 2018, were recorded in a nationwide database among infectious disease specialists. Demographics, clinical, and
virological outcomes were analyzed.
Results: A total of 552 patients were included in the study. The mean age of the patients was 51.28 ± 14.2, and 293 (55.8%) were female.
The majority had HCV genotype 1b infection (65%), 75.04% of the patients underwent treatment, and non-cirrhosis was present at
baseline in 381 patients (72.6%). SOF/LDV ± RBV treatment was given to 477 patients and 48 patients received SOF/RBV according to
HCV genotype. The total SVR12 rate was 99% in all patients. Five patients experienced disease relapse during the study and all of them
were genotype 2. In patients infected with HCV GT2, SVR12 was 77.3%. SVR was 100% in all patients infected with other HCV genotypes.
All treatments were well tolerated by patients without causing severe adverse events. Side effects and side effects-associated
treatment discontinuation rates were 28.2% and 0.4%, respectively. Weakness (13.7%) was the common side effect.
Conclusion: The present real-world data of 525 patients with HCV genotypes 1, 1a, 1b, 3, 4, and 5 who underwent SOF/LDV ± RBV treatment
in Turkey demonstrated a high efficacy and safety profile. HCV GT2 patients should be treated with more efficacious treatment.
AU  - Demirturk, Nese
AU  - Doğan, Nurhan
AU  - Hakyemez, Ismail Necati
AU  - ŞENER, Alper
AU  - AYGEN, Bilgehan
AU  - Barut, Sener
AU  - SALTOĞLU, Neşe
AU  - ÖRMEN, Bahar
AU  - SİLİ, Uluhan
AU  - ÇAGATAY, ARIF ATAHAN
AU  - KINIKLI, SAMI
AU  - ASAN, Ali
AU  - TARAKÇI, Hüseyin
AU  - GÜZEL, Deniz KOMALAK
AU  - SİMSEK, FUNDA
AU  - TUNA, Nazan
AU  - ŞİMŞEK, Sümeyra
AU  - Aktug Demir, Nazlim
AU  - Türkoğlu Yılmaz, Emine
AU  - CELEN, MUSTAFA
AU  - Turker, Nesrin
AU  - Bilgin, Huseyin
AU  - Tuncer Ertem, Gunay
AU  - süer, kaya
AU  - konya, petek
AU  - İNAN, DİLARA
AU  - Tulek, Necla
AU  - karakeçili, faruk
AU  - ÖZEL, Selcan ARSLAN
AU  - Gürbüz, Yunus
AU  - korkmaz, pınar
AU  - AKHAN, Sıla
AU  - mıstık, reşit
AU  - ERSÖZ, Gülden
AU  - Ural, Onur
AU  - Batirel, Ayse
AU  - Öztürk, Sinan
AU  - Kuruüzüm, Ziya
AU  - YILDIZ, Orhan
AU  - Çelik, İlhami
AU  - Cetinkaya, Riza Aytac
DO  - 10.5152/tjg.2020.19569
PY  - 2021
JO  - Turkish Journal of Gastroenterology
VL  - 32
IS  - 2
SN  - 1300-4948
SP  - 155
EP  - 163
DB  - TRDizin
UR  - http://search/yayin/detay/511870
ER  -