Differential diagnosis of COVID-19 pneumonia
from acute heart failure in pandemic:
Importance of radiological and laboratory
findings

YALÇINSOY, MURAT; Kasapoglu, Umut Sabri; Güneş, Ajda; Karaca, Rukan; ÇAĞAŞAR, ÖZLEM; şayan, hasan; Acun Delen, Leman; KACMAZ, OSMAN; Gök, Abdullah; Pembegul, Irem

doi:10.5578/tt.20219807

Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings

Umut Sabri KASAPOĞLU, (Malatya Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları ve Yoğun Bakım Kliniği, Malatya, Türkiye)

Abdullah GÖK, (Malatya Eğitim ve Araştırma Hastanesi, Anesteziyoloji ve Reanimasyon Kliniği, Malatya, Türkiye)

Leman ACUN DELEN, (Malatya Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Malatya, Türkiye)

Hasan ŞAYAN, (Malatya Eğitim ve Araştırma Hastanesi, Anesteziyoloji ve Reanimasyon Kliniği, Malatya, Türkiye)

Osman KAÇMAZ, (Malatya Eğitim ve Araştırma Hastanesi, Anesteziyoloji ve Reanimasyon Kliniği, Malatya, Türkiye)

ÖZLEM ÇAĞAŞAR, (Malatya Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Malatya, Türkiye)

Rukan KARACA, (Malatya Eğitim ve Araştırma Hastanesi, Radyoloji Kliniği, Malatya, Türkiye)

Ajda GÜNEŞ, (Malatya Eğitim ve Araştırma Hastanesi, Hematoloji Kliniği, Malatya, Türkiye)

İrem PEMBEGÜL, (Malatya Turgut Özal Üniversitesi, Nefroloji Bilim Dalı, Malatya, Türkiye)

Murat YALÇINSOY (İnönü Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Malatya, Türkiye)

Tüberküloz ve Toraks

5 0

Yıl: 2021 Cilt: 69 Sayı: 2 Sayfa Aralığı: 177 - 186 Metin Dili: İngilizce DOI: 10.5578/tt.20219807 İndeks Tarihi: 01-06-2022

Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings

Öz:

Introduction: COVID-19 pneumonia typically presents with high fever, cough, and shortness of breath and on thorax computed tomography (CT) peripheral ground glass opacities help the diagnosis. Although typical imaging findings for COVID-19 pneumonia are specified in thorax CT, these findings can be confused with other diseases. The aim of this study is to investigate the roles of radiological imaging and laboratory findings in the differential diagnosis of COVID-19 pneumonia and acute heart failure (AHF). Materials and Methods: In the present study, 74 patients who admitted to the emergency department with respiratory distress during the pandemic period and received a diagnosis of COVID-19 pneumonia and AHF were included. Laboratory data and radiological findings of the patients, at the time of admission, were evaluated. Results: On admission, there was no difference in age, gender between two groups. However, COVID-19 exposure history was found significantly higher in COVID-19 pneumonia patients group (p< 0.001). Fever, cough, and fatigue were found significantly higher in the COVID-19 pneumonia patients group (p< 0.001). There was difference of lesions distribution between the two groups, centrally distributed lesions were found significantly higher in acute heart failure patients (p< 0.001). Pleural effusion and cardiomegaly were found significantly higher in AHF patients (p< 0.001, p< 0.001). Counts of the white blood cells and lymphocytes were found significantly lower in COVID-19 pneumonia patients (p= 0.003, p= 0.009). COVID-19 pneumonia patients had significantly higher levels of CRP, ferritin, LDH and CK compared with AHF patients (p< 0.001, p< 0.001, p= 0.002, p= 0.013). However the level of NT-proBNP was found significantly higher in the AHF patients group (p< 0.001). Conclusion: We believe that laboratory data and thorax CT findings can provide beneficial clinical information in differentiating COVID-19 pneumonia from AHF during the pandemic

Anahtar Kelime:

Pandemide COVID-19 pnömonisinin akut kalp yetmezliğinden ayırıcı tanısı: Radyolojik bulguların ve laboratuvar bulgularının önemi

Öz:

Giriş: COVID-19 pnömonisi tipik olarak yüksek ateş, öksürük, nefes darlığı ile klinik prezente olmakta ve toraks BT’de periferal buzlu cam dansitelerinin görülmesi tanıya yardımcı olmaktadır. Her ne kadar toraks BT’de COVID-19 pnömonisi için tipik görüntüleme bulguları belirtilmiş olsa da, COVID-19 pnömonisinin toraks BT görüntüleme bulguları birçok hastalık ile karışabilmektedir. Bu çalışmada radyolojik görüntüleme bulgularının ve laboratuvar bulgularının COVID-19 pnömonisi ve akut kalp yetmezliği (AKY) ayırıcı tanısında yerinin olup olmadığının araştırılması amaçlanmıştır. Materyal ve Metod: Çalışmaya pandemi sürecinde acil servise solunum sıkıntısı ile başvuran, COVID-19 pnömonisi ve AKY tanısı alan toplam 74 hasta dahil edilmiştir. Olguların hastaneye başvuru sırasındaki laboratuar verileri ve radyolojik bulguları değerlendirilmiştir. Bulgular: Başvuru sırasında, iki grup arasında yaş ve cinsiyet açısından fark yoktu. Bununla birlikte, COVID-19 maruziyet öyküsü, COVID-19 pnömonisi hasta grubunda anlamlı olarak daha yüksek bulundu (p< 0,001). COVID-19 pnömonisi hasta grubunda ateş, öksürük ve yorgunluk anlamlı olarak yüksek bulundu (p< 0,001). İki grup arasında lezyon dağılımı açısından farklılıklar mevcuttu, santral yerleşim gösteren lezyonlar AKY hastalarında anlamlı olarak daha yüksek bulundu (p< 0,001). AKY hastalarında plevral efüzyon ve kardiyomegali anlamlı olarak yüksek bulundu (p< 0,001, p< 0,001). COVID-19 pnömonisi olgularında lökosit ve lenfosit sayıları anlamlı olarak düşük bulundu (p= 0,003, p= 0,009). COVID-19 pnömonisi hastaları, AKY hastalarına kıyasla anlamlı olarak daha yüksek CRP, ferritin, LDH ve CK seviyelerine sahipti (p< 0,001, p< 0,001, p= 0,002, p= 0,013). Ancak NT-proBNP düzeyi ABY hasta grubunda anlamlı olarak yüksek bulundu (p< 0,001). Sonuç: Laboratuvar verilerinin ve toraks BT bulgularının pandemi sürecinde COVID-19 pnömonisini AKY’den ayırt etmede faydalı klinik bilgiler sağlayabileceğine inanıyoruz.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kasapoglu U, Gök A, Acun Delen L, şayan h, KACMAZ O, ÇAĞAŞAR Ö, Karaca R, Güneş A, Pembegul I, YALÇINSOY M (2021). Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. , 177 - 186. 10.5578/tt.20219807
Chicago	Kasapoglu Umut Sabri,Gök Abdullah,Acun Delen Leman,şayan hasan,KACMAZ OSMAN,ÇAĞAŞAR ÖZLEM,Karaca Rukan,Güneş Ajda,Pembegul Irem,YALÇINSOY MURAT Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. (2021): 177 - 186. 10.5578/tt.20219807
MLA	Kasapoglu Umut Sabri,Gök Abdullah,Acun Delen Leman,şayan hasan,KACMAZ OSMAN,ÇAĞAŞAR ÖZLEM,Karaca Rukan,Güneş Ajda,Pembegul Irem,YALÇINSOY MURAT Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. , 2021, ss.177 - 186. 10.5578/tt.20219807
AMA	Kasapoglu U,Gök A,Acun Delen L,şayan h,KACMAZ O,ÇAĞAŞAR Ö,Karaca R,Güneş A,Pembegul I,YALÇINSOY M Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. . 2021; 177 - 186. 10.5578/tt.20219807
Vancouver	Kasapoglu U,Gök A,Acun Delen L,şayan h,KACMAZ O,ÇAĞAŞAR Ö,Karaca R,Güneş A,Pembegul I,YALÇINSOY M Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. . 2021; 177 - 186. 10.5578/tt.20219807
IEEE	Kasapoglu U,Gök A,Acun Delen L,şayan h,KACMAZ O,ÇAĞAŞAR Ö,Karaca R,Güneş A,Pembegul I,YALÇINSOY M "Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings." , ss.177 - 186, 2021. 10.5578/tt.20219807
ISNAD	Kasapoglu, Umut Sabri vd. "Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings". (2021), 177-186. https://doi.org/10.5578/tt.20219807

APA	Kasapoglu U, Gök A, Acun Delen L, şayan h, KACMAZ O, ÇAĞAŞAR Ö, Karaca R, Güneş A, Pembegul I, YALÇINSOY M (2021). Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. Tüberküloz ve Toraks, 69(2), 177 - 186. 10.5578/tt.20219807
Chicago	Kasapoglu Umut Sabri,Gök Abdullah,Acun Delen Leman,şayan hasan,KACMAZ OSMAN,ÇAĞAŞAR ÖZLEM,Karaca Rukan,Güneş Ajda,Pembegul Irem,YALÇINSOY MURAT Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. Tüberküloz ve Toraks 69, no.2 (2021): 177 - 186. 10.5578/tt.20219807
MLA	Kasapoglu Umut Sabri,Gök Abdullah,Acun Delen Leman,şayan hasan,KACMAZ OSMAN,ÇAĞAŞAR ÖZLEM,Karaca Rukan,Güneş Ajda,Pembegul Irem,YALÇINSOY MURAT Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. Tüberküloz ve Toraks, vol.69, no.2, 2021, ss.177 - 186. 10.5578/tt.20219807
AMA	Kasapoglu U,Gök A,Acun Delen L,şayan h,KACMAZ O,ÇAĞAŞAR Ö,Karaca R,Güneş A,Pembegul I,YALÇINSOY M Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. Tüberküloz ve Toraks. 2021; 69(2): 177 - 186. 10.5578/tt.20219807
Vancouver	Kasapoglu U,Gök A,Acun Delen L,şayan h,KACMAZ O,ÇAĞAŞAR Ö,Karaca R,Güneş A,Pembegul I,YALÇINSOY M Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings. Tüberküloz ve Toraks. 2021; 69(2): 177 - 186. 10.5578/tt.20219807
IEEE	Kasapoglu U,Gök A,Acun Delen L,şayan h,KACMAZ O,ÇAĞAŞAR Ö,Karaca R,Güneş A,Pembegul I,YALÇINSOY M "Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings." Tüberküloz ve Toraks, 69, ss.177 - 186, 2021. 10.5578/tt.20219807
ISNAD	Kasapoglu, Umut Sabri vd. "Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings". Tüberküloz ve Toraks 69/2 (2021), 177-186. https://doi.org/10.5578/tt.20219807