Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder
Yıl: 2021 Cilt: 10 Sayı: 1 Sayfa Aralığı: 31 - 35 Metin Dili: İngilizce DOI: 10.5505/respircase.2021.10437 İndeks Tarihi: 01-06-2022
Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder
Öz: A 33-year-old male patient with a diagnosis of obsessive-compulsive disorder applied to the emergency department with fever, cough, sputum and increasing shortness of breath. A physical examination revealed the patient to be dyspneic and orthopneic. Bilateral rales were present in middle and basal lung areas. Oxygen saturation in room air was 84%. Diffuse
parenchymal infiltration and consolidation areas were noted in a posteroanterior chest X-ray and a thorax computerized tomography. The patient’s history revealed that the patient used a CPAP machine due to obstructive sleep apnea syndrome and aripiprazole, related to his obsessive-compulsive disorder. The patient was hospitalized in the intensive care unit with a preliminary diagnosis of pneumonia and treated with ceftriaxone 2 gr/day, clarithromycin 2x500 mg and oseltamivir 2x75 mg. Blood and sputum cultures, viral markers and procalcitonin were negative, and so methylprednisolone 40mg/day was started. The patient’s clinical condition improved rapidly after treatment with steroids, and he was discharged on the 8th day after admission, with recommendations for ambulatory care. It was learnt that aripiprazole had been added to his treatment for obsessive-compulsive disorder 1 month earlier, and that his complaints had started and gradually intensified 20 days after this change in medication. The patient’s clinical picture was assessed as lung toxicity caused by aripiprazole.
Anahtar Kelime: Obsesif-Kompulsif Bozukluk Tanılı Hastada Aripirazol İlişkili Akciğer Toksitesi
Öz: Obsesif-kompulsif bozukluk tanısı olan 33 yaşında erkek hasta acil servise, ateş, öksürük, balgam ve giderek artan nefes darlığı ile başvurdu. Fizik muaye nesinde dispneik ve ortopneik idi. Dinlemekle bilateral akciğer orta ve basallerde ralleri mevcuttu. Oda havasında oksijen saturasyonu %84 idi. Direkt akciğer grafisi ve toraks bilgisayarlı tomografisinde her iki
akciğerde yaygın parankimal infiltrasyon ve konsolidasyon alanları mevcuttu. Hikayesinde obstrüktif uyku apne sendromu için CPAP ve obsessif –kompulsif bozukluk nedeniyle de aripipirazol kullandığı öğrenildi. Hasta pnömoni ön tanısıyla yoğun bakıma yatırılarak seftriakson 2 gr/gün, klaritromisin 2x500 mg ve oseltamivir 2x75 mg tedavisi başlandı. Yapılan kan ve balgam kültüründe üreme olmadı. Viral markırları ve procalsitonin negatif geldi. Bunun üzerine metil prednisolon 40 mg/gün başlandı. Steroid tedavisinden sonra kliniği hızla düzeldi. Yatışının 8. günü hasta ayaktan takip edilmek üzere önerilerle taburcu edildi. Obsessif- kompulsif bozukluk için tedavisine 1 ay önce aripipirazol eklenmiş ve şikayetleri bu ilaç
değişikliğinden 20 gün sonra başlayarak giderek şiddetlenmiş olduğu öğrenildi. Bu nedenle klinik tablo aripiprazole bağlı akciğer toksisitesi olarak değerlendirildi.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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| APA | ALA F, DUYGULU M, KÖKSAL N, TUNA T (2021). Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. , 31 - 35. 10.5505/respircase.2021.10437 |
| Chicago | ALA Fatme Selen,DUYGULU Mustafa Emre,KÖKSAL NURHAN,TUNA Tibel Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. (2021): 31 - 35. 10.5505/respircase.2021.10437 |
| MLA | ALA Fatme Selen,DUYGULU Mustafa Emre,KÖKSAL NURHAN,TUNA Tibel Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. , 2021, ss.31 - 35. 10.5505/respircase.2021.10437 |
| AMA | ALA F,DUYGULU M,KÖKSAL N,TUNA T Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. . 2021; 31 - 35. 10.5505/respircase.2021.10437 |
| Vancouver | ALA F,DUYGULU M,KÖKSAL N,TUNA T Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. . 2021; 31 - 35. 10.5505/respircase.2021.10437 |
| IEEE | ALA F,DUYGULU M,KÖKSAL N,TUNA T "Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder." , ss.31 - 35, 2021. 10.5505/respircase.2021.10437 |
| ISNAD | ALA, Fatme Selen vd. "Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder". (2021), 31-35. https://doi.org/10.5505/respircase.2021.10437 |
| APA | ALA F, DUYGULU M, KÖKSAL N, TUNA T (2021). Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. Respiratory Case Reports, 10(1), 31 - 35. 10.5505/respircase.2021.10437 |
| Chicago | ALA Fatme Selen,DUYGULU Mustafa Emre,KÖKSAL NURHAN,TUNA Tibel Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. Respiratory Case Reports 10, no.1 (2021): 31 - 35. 10.5505/respircase.2021.10437 |
| MLA | ALA Fatme Selen,DUYGULU Mustafa Emre,KÖKSAL NURHAN,TUNA Tibel Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. Respiratory Case Reports, vol.10, no.1, 2021, ss.31 - 35. 10.5505/respircase.2021.10437 |
| AMA | ALA F,DUYGULU M,KÖKSAL N,TUNA T Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. Respiratory Case Reports. 2021; 10(1): 31 - 35. 10.5505/respircase.2021.10437 |
| Vancouver | ALA F,DUYGULU M,KÖKSAL N,TUNA T Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder. Respiratory Case Reports. 2021; 10(1): 31 - 35. 10.5505/respircase.2021.10437 |
| IEEE | ALA F,DUYGULU M,KÖKSAL N,TUNA T "Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder." Respiratory Case Reports, 10, ss.31 - 35, 2021. 10.5505/respircase.2021.10437 |
| ISNAD | ALA, Fatme Selen vd. "Aripiprazole-Induced Pulmonary Toxicity in a Patient with Obsessive-Compulsive Disorder". Respiratory Case Reports 10/1 (2021), 31-35. https://doi.org/10.5505/respircase.2021.10437 |
