TRİİYODOANİLİN’İN SENTEZLENMESİ,
NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO
KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN
İNCELENMESİ

ÖZAKAR, Rukiye Sevinç Özakar; KOCA, MEHMET; ÖZAKAR, Emrah Özakar

doi:10.33483/jfpau.811737

TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ

Mehmet KOCA, (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, 25240, Erzurum, Türkiye)

Emrah ÖZAKAR, (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, 25240, Erzurum, Türkiye)

Rukiye SEVİNÇ ÖZAKAR (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, 25240, Erzurum, Türkiye)

Ankara Üniversitesi Eczacılık Fakültesi Dergisi

3 2

Yıl: 2021 Cilt: 45 Sayı: 2 Sayfa Aralığı: 264 - 283 Metin Dili: Türkçe DOI: 10.33483/jfpau.811737 İndeks Tarihi: 03-06-2022

TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ

Öz:

Amaç: Suda çözünürlüğü bulunmayan iyot bazlı triiyodoanilin (TIA) radyokontrast bileşiğinin sentezini ve nanosüspansiyonunu yapmak, karakterizasyonlarını gerçekleştirmek ve Bilgisayarlı Tomografi (BT) görüntülemede sıklıkla kullanılan iopromid ve ioheksol ile kıyaslamak. Gereç ve Yöntem: TIA sentezi ultrasonik ses dalgaları kullanılarak ve nanokristaller ise sentezlenen bu maddeden hareketle nanopresipitasyon yöntemi ile elde edilmiştir. TIA’nın karakterizasyonu için NMR ve QTOF analizleri yapılmıştır. Nanokristallerin karakterizasyonu için ise optik mikroskop, zeta potansiyel, partikül boyutu ve dağılımı, SEM ve FT-IR analizleri yapılmıştır. Elde edilen nanosüspansiyon, BT tekniği ile iopromid ve ioheksol.ile radyokontrast özellikleri açısından kıyaslanmıştır. Sonuç ve Tartışma: Sentezlenen saf TIA’dan hareketle hazırlanan nanokristallerin boyutları ~699 nm, zeta potansiyelleri ise ~(-)16 mV olarak bulunmuştur. SEM ve optik mikroskop görüntüleri ile morfolojileri belirlenmiştir. Elde edilen nanokristallerin, sentezlenen TIA’dan farklı bir yapı sergilemediği FT-IR ile tespit edilmiştir. BT görüntülerinde TIA nanosüspansiyonunun, aynı miktardaki iopromid ve ioheksolden yaklaşık ~%40 daha fazla kontrast özellik sergilediği tespit edilmiştir. Sonuç olarak nanokristallerin kendi sahip oldukları eşsiz özellikleri ile daha az radyokontrast madde kullanılarak benzer nitelikte görüntüleme yapılabileceği gösterilmiştir. Bu sayede daha düşük dozda kullanım sunması sebebiyle daha az yan etki ve/veya toksik etki oluşturması muhtemeldir. Elde edilen bu başarılı sonuçlar ışığında, klinik deneyler ile bu çalışmanın gelecekte detaylandırılması planlanmaktadır

Anahtar Kelime:

SYNTHESIS OF TRIIODOANILINE, PREPARATION OF NANOSUSPENSIONS, IN VITRO CHARACTERIZATION AND INVESTIGATION OF RADIOCONTRAST PROPERTIES

Öz:

BSTRACT Objective: Synthesis and nanosuspension preparation of iodine-based triiodoaniline (TIA) radiocontrast compound, which is not soluble in water, perform their characterization and compare with iopromide and iohexol, which are frequently used in Computed Tomography (CT) imaging. Material and Method: TIA synthesis was obtained using ultrasonic sound waves, and nanocrystals were obtained by nanoprecipitation method from this synthesized substance. NMR and Q-TOF analyzes were performed for the characterization of TIA. For the characterization of nanocrystals, optical microscope, zeta potential, particle size, and distribution, SEM and FT-IR analyzes were performed. The obtained nanosuspension was compared by the CT technique with iopromide and iohexol in terms of radiocontrast properties. Result and Discussion: The size of the prepared nanoparticles based on the synthesized pure TIA was found to be ~699 nm and zeta potentials as ~ (-)16 mW. Morphologies were determined by SEM and optical microscope images. It was determined by FT-IR that the obtained nanocrystals do not exhibit a different structure than the synthesized TIA. On CT images, TIA nanosuspension was found to exhibit ~ 40% more contrast than the same amount of iopromide and iohexol. As a result, it has been shown that nanocrystals can perform similar imaging by using less radiocontrast materials with their unique properties. In this way, it is likely to cause fewer side effects and/or toxic effects due to the lower dosage. In the light of these successful results, it is planned to detail this study with clinical trials in the future

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KOCA M, ÖZAKAR E, ÖZAKAR R (2021). TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. , 264 - 283. 10.33483/jfpau.811737
Chicago	KOCA MEHMET,ÖZAKAR Emrah Özakar,ÖZAKAR Rukiye Sevinç Özakar TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. (2021): 264 - 283. 10.33483/jfpau.811737
MLA	KOCA MEHMET,ÖZAKAR Emrah Özakar,ÖZAKAR Rukiye Sevinç Özakar TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. , 2021, ss.264 - 283. 10.33483/jfpau.811737
AMA	KOCA M,ÖZAKAR E,ÖZAKAR R TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. . 2021; 264 - 283. 10.33483/jfpau.811737
Vancouver	KOCA M,ÖZAKAR E,ÖZAKAR R TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. . 2021; 264 - 283. 10.33483/jfpau.811737
IEEE	KOCA M,ÖZAKAR E,ÖZAKAR R "TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ." , ss.264 - 283, 2021. 10.33483/jfpau.811737
ISNAD	KOCA, MEHMET vd. "TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ". (2021), 264-283. https://doi.org/10.33483/jfpau.811737

APA	KOCA M, ÖZAKAR E, ÖZAKAR R (2021). TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 45(2), 264 - 283. 10.33483/jfpau.811737
Chicago	KOCA MEHMET,ÖZAKAR Emrah Özakar,ÖZAKAR Rukiye Sevinç Özakar TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi 45, no.2 (2021): 264 - 283. 10.33483/jfpau.811737
MLA	KOCA MEHMET,ÖZAKAR Emrah Özakar,ÖZAKAR Rukiye Sevinç Özakar TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, vol.45, no.2, 2021, ss.264 - 283. 10.33483/jfpau.811737
AMA	KOCA M,ÖZAKAR E,ÖZAKAR R TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2021; 45(2): 264 - 283. 10.33483/jfpau.811737
Vancouver	KOCA M,ÖZAKAR E,ÖZAKAR R TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2021; 45(2): 264 - 283. 10.33483/jfpau.811737
IEEE	KOCA M,ÖZAKAR E,ÖZAKAR R "TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ." Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 45, ss.264 - 283, 2021. 10.33483/jfpau.811737
ISNAD	KOCA, MEHMET vd. "TRİİYODOANİLİN’İN SENTEZLENMESİ, NANOSÜSPANSİYONLARININ HAZIRLANMASI, İN VİTRO KARAKTERİZASYONU VE RADYOKONTRAST ÖZELLİKLERİNİN İNCELENMESİ". Ankara Üniversitesi Eczacılık Fakültesi Dergisi 45/2 (2021), 264-283. https://doi.org/10.33483/jfpau.811737