TY  - JOUR
TI  - Nectin-2 and Nectin-4 Adhesion Molecules in Patients with
Breast Cancer
AB  - Evaluation of the nectin-2 and nectin-4 protein and mRNA expression levels is aimed in this study, with
concerning diagnostic and predictive value in breast cancer patients.
METHODS
Sixty patients with pathologically and radiologically verified breast cancer who were treated at the Istanbul
University, Institute of Oncology, between 2017 and 2018 are included in the study. Circulating
nectin-2 and nectin-4 protein levels were evaluated by solid-phase enzyme-linked immunosorbent assay
(Abbkine Scientific Co., Ltd.). For analyzing nectin-2- and nectin-4-specific mRNA in sera of the
patients, circulating cell-free RNA was extracted from serum using a monophasic phenol and guanidine
thiocyanate solution (Roche, Mannheim, Germany), according to the manufacturer’s protocol.
RESULTS
The median age of patients was 53 years. The mean tumor size was 30.21±17.32 mm. Forty-one patients
were in the luminal group. Lymph node involvement was detected in 25 patients. The nectin-4 expression
level was statistically significantly higher in those with Ki-67 ≥30 and those with positive distant
metastasis compared to the other group. In addition, nectin-2 expression was higher in patients with
Grade 3 tumors.
CONCLUSION
High levels of nectin-2 and nectin-4 expression in the serum of patients correlate with poor disease
characteristics of breast cancer.
AU  - ÜÇÜNCÜ, Muhammed Zubeyr
AU  - BADEMLER, Süleyman
AU  - VATANSEVER, Sezai
AU  - SERİLMEZ, Murat
AU  - AK, Naziye
DO  - 10.5505/tjo.2021.2697
PY  - 2021
JO  - Türk Onkoloji Dergisi
VL  - 36
IS  - 2
SN  - 1300-7467
SP  - 165
EP  - 170
DB  - TRDizin
UR  - http://search/yayin/detay/514113
ER  -