TY  - JOUR
TI  - Impact of Seizures and Anti-epileptic Drug Use on
Survival in Patients with World Health Organization
Grade II Glioma
AB  - Epileptic seizures are prognostic for low-grade gliomas. However, the impact of anti-epileptic drug use
(AED) on outcomes is unclear. We aimed to evaluate the impact of epileptic seizures and AED use on
tumor control and survival rates after radiotherapy (RT) in patients with World Health Organization
Grade II glioma.
METHODS
A total of 182 patients who underwent RT either early after surgery or in case of progression were retrospectively
evaluated. The primary end point was the impact of seizures on overall survival (OS), local
control (LC), and progression-free survival (PFS) rates. The secondary end point was the impact of AED
use on these rates.
RESULTS
Median follow-up was 80 months. The number of patients with epileptic seizures at the time of diagnosis
was 113 (62%). The 2-, 5-, and 10-year OS, LC, and PFS rates were significantly higher in patients
with seizures (p=0.022 and p=0.001, respectively). When patients that did and did not use AED were
compared, OS, LC, and PFS rates were similar. Besides, using AEDs in patients without seizures did not
affect the OS, LC, and PFS rates. Carbamazepine use was associated with higher OS and PFS rates with
a non-significant increase in LC. Phenytoin use yielded an increase in the PFS and LC rates in the first 2
years which turned to opposite after the 6th year.
CONCLUSION
Seizures at the time of diagnosis and using AEDs for the treatment of seizures both increase survival rates in patients
with Grade II glioma. Patients using carbamazepine had increased survival rates.
AU  - Zorlu, Faruk
AU  - YAZICI, Gözde
AU  - YÜCE SARI, Sezin
AU  - ÇAĞLAR, Ahmetcan
AU  - CENGİZ, Mustafa
DO  - 10.5505/tjo.2021.2660
PY  - 2021
JO  - Türk Onkoloji Dergisi
VL  - 36
IS  - 2
SN  - 1300-7467
SP  - 206
EP  - 214
DB  - TRDizin
UR  - http://search/yayin/detay/514128
ER  -