Th1 and Th2 inducing cytokines in cystic echinococcosis

MEHMET, Nihayet; DURMAZ, RIZA; BAYRAKTAR, Mehmet Refik

Th1 and Th2 inducing cytokines in cystic echinococcosis

Mehmet Refik BAYRAKTAR, (İnönü Üniversitesi, Tıp Fakültesi, Klinik Mikrobiyoloji Anabilim Dalı, Malatya, Türkiye)

Nihayet MEHMET, (İnönü Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Malatya, Türkiye)

Rıza DURMAZ (İnönü Üniversitesi, Tıp Fakültesi, Klinik Mikrobiyoloji Anabilim Dalı, Malatya, Türkiye)

Türkiye Parazitoloji Dergisi

5 0

Yıl: 2005 Cilt: 29 Sayı: 3 Sayfa Aralığı: 167 - 170 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Th1 and Th2 inducing cytokines in cystic echinococcosis

Öz:

Bu çalışma Turgut Özal Tıp Merkezi/Malatya'da toplam 62 olgunun katılımıyla düzenlendi. Bunların 32'si larval dönem CE enfeksiyonu olan, 30'u ise sağlıklı bireylerdi. Erkek, kadın oranı 0.45 idi. CE, her yaş grubunda görüldü; en genç hasta 12 yıl yaşında, en yaşlısı ise 74 yıl yaşındaydı. Kist hidatik lokalizasyonu en sık karaciğerde (%78,1), daha sonra akciğerde (%15,7) ve bir vakada da beyindeydi. 35 yaşında, karaciğer ve amentumda multipl kistleri (12 kist) olan bayan hasta dışında bütün olgular tamamen iyileştiler. Olgularda en fazla yükselen sitokin %65,7 oranıyla IL-4 oldu. IL-2'dek artış %46,8, İL-10 artışı %40,6 olarak bulundu. Bu sonuçlar, CE'da farklı immunregulatör olayda ve sitokin cevabı'nın olduğunu ve bu hastalarda hafif monositozun olabileceğini gösterdi. Sonuç olarak. CE' da Thl ve Th2 sitokinlerinin bir arada bulunduğu ve Th2 sitokinlerin daha baskın olduğu görüldü.

Anahtar Kelime: Th1 hücreleri Sitokinler Ekinokokkoz Th2 hücreleri

Konular: Genel ve Dahili Tıp Parazitoloji

Kistik ekinokokkozta Th1 ve Th 2 yi indükleyen sitokinler

Öz:

This study included 62 subjects who presented at the Turgut Özal Medical Centre in Malatya. Of these, 32 were infected with the larval stage of Echinococcus granulosus and the remaining 30 were healthy controls. The ratio of males to females was 0.45. Cystic echinococcosis (CE) occurred in all age*'groups; the youngest case was 12 years and the oldest case was 74 years old. The frequency of hydatid cysts located in liver was (78.1%) followed by lungs (15.7 %) and one in the brain. All patients recovered completely except for one woman (35 years old) in whom multiple cysts (21cysts) were detected in liver and omentum two years after the first operation. In 68.7 % of the cases, the cytokine, that was most frequently increased was IL-4. The IL-2 cytokine increased to 46.8% followed by IL-10 (40.6 %). These results suggest that there are different immunoregulatory events and the cytokine response during CE may be in part related to the slight monocytosis observed in CE patients. In conclusion, concurrent Thl and Th2 cytokine-type profiles were expressed in CE with the predominance of type Th2 cytokines.

Anahtar Kelime: Th2 Cells Th1 Cells Cytokines Echinococcosis

Konular: Genel ve Dahili Tıp Parazitoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BAYRAKTAR M, MEHMET N, DURMAZ R (2005). Th1 and Th2 inducing cytokines in cystic echinococcosis. , 167 - 170.
Chicago	BAYRAKTAR Mehmet Refik,MEHMET Nihayet,DURMAZ RIZA Th1 and Th2 inducing cytokines in cystic echinococcosis. (2005): 167 - 170.
MLA	BAYRAKTAR Mehmet Refik,MEHMET Nihayet,DURMAZ RIZA Th1 and Th2 inducing cytokines in cystic echinococcosis. , 2005, ss.167 - 170.
AMA	BAYRAKTAR M,MEHMET N,DURMAZ R Th1 and Th2 inducing cytokines in cystic echinococcosis. . 2005; 167 - 170.
Vancouver	BAYRAKTAR M,MEHMET N,DURMAZ R Th1 and Th2 inducing cytokines in cystic echinococcosis. . 2005; 167 - 170.
IEEE	BAYRAKTAR M,MEHMET N,DURMAZ R "Th1 and Th2 inducing cytokines in cystic echinococcosis." , ss.167 - 170, 2005.
ISNAD	BAYRAKTAR, Mehmet Refik vd. "Th1 and Th2 inducing cytokines in cystic echinococcosis". (2005), 167-170.

APA	BAYRAKTAR M, MEHMET N, DURMAZ R (2005). Th1 and Th2 inducing cytokines in cystic echinococcosis. Türkiye Parazitoloji Dergisi, 29(3), 167 - 170.
Chicago	BAYRAKTAR Mehmet Refik,MEHMET Nihayet,DURMAZ RIZA Th1 and Th2 inducing cytokines in cystic echinococcosis. Türkiye Parazitoloji Dergisi 29, no.3 (2005): 167 - 170.
MLA	BAYRAKTAR Mehmet Refik,MEHMET Nihayet,DURMAZ RIZA Th1 and Th2 inducing cytokines in cystic echinococcosis. Türkiye Parazitoloji Dergisi, vol.29, no.3, 2005, ss.167 - 170.
AMA	BAYRAKTAR M,MEHMET N,DURMAZ R Th1 and Th2 inducing cytokines in cystic echinococcosis. Türkiye Parazitoloji Dergisi. 2005; 29(3): 167 - 170.
Vancouver	BAYRAKTAR M,MEHMET N,DURMAZ R Th1 and Th2 inducing cytokines in cystic echinococcosis. Türkiye Parazitoloji Dergisi. 2005; 29(3): 167 - 170.
IEEE	BAYRAKTAR M,MEHMET N,DURMAZ R "Th1 and Th2 inducing cytokines in cystic echinococcosis." Türkiye Parazitoloji Dergisi, 29, ss.167 - 170, 2005.
ISNAD	BAYRAKTAR, Mehmet Refik vd. "Th1 and Th2 inducing cytokines in cystic echinococcosis". Türkiye Parazitoloji Dergisi 29/3 (2005), 167-170.