TY  - JOUR
TI  - Melatonin, aging, and COVID-19: Could melatonin be beneficial for
COVID-19 treatment in the elderly?
AB  - The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related
diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some
of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence
many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular
functions. Melatonin rhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process.
Melatonin levels decline considerably with aging and its decline is associated with several age-related diseases. Aging is closely associated
with oxidative damage and mitochondrial dysfunction. Free radical reactions initiated by the mitochondria constitute the inherent
aging process. Melatonin plays a pivotal role in preventing age-related oxidative stress. Coronavirus disease 2019 (COVID-19) fatality
rates increase with chronic diseases and age, where melatonin levels decrease. For this reason, melatonin supplementation in elderly
could be beneficial in COVID-19 treatment. Therefore, studies on the usage of melatonin in COVID-19 treatment are needed.
AU  - OZTÜRK, GÜLER
AU  - Guney, Sevin
AU  - Akbulut, K Gonca
DO  - 10.3906/sag-2005-356
PY  - 2020
JO  - Turkish Journal of Medical Sciences
VL  - 50
IS  - 6
SN  - 1300-0144
SP  - 1504
EP  - 1512
DB  - TRDizin
UR  - http://search/yayin/detay/514427
ER  -