Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez
Yıl: 2021 Cilt: 45 Sayı: 3 Sayfa Aralığı: 290 - 300 Metin Dili: İngilizce DOI: 10.3906/tar-2009-2 İndeks Tarihi: 06-06-2022
Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez
Öz: In this study, the total phenolic content (TPC), total flavonoid content (TFC), in vitro antioxidant capacity and individual
phenolic compounds of Juniperus drupacea Labill berry and pekmez (molasses) were determined. Since pekmez was the only edible
form of berry, the bioaccessibility of phenolic compounds and the antioxidant capacity of the pekmez were assessed following exposure
to simulated gastrointestinal conditions. The phenolic compounds determined in the berry and pekmez were similar, while the pekmez
was especially rich in protocatechuic acid, and additionally, the berries were rich catechin and chrysin. Generally, through oral to
the intestinal stage of the simulated gastric conditions, the phenolic levels decreased. Although protocatechuic acid was the major
phenolic compound at the initial stage, the highest bioaccessibility was observed for catechin and p-hydroxybenzoic acid. In terms of
the antioxidant capacity determined by four different methods, the dialyzed fraction (IN) was 0.77-12.19% of the initial values. In this
study, detailed information on the antioxidant capacity and phenolic compounds of Juniperus drupacea Labill pekmez and their change
through the simulated gastrointestinal conditionswereevaluated for the first-time.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Akinci I, Ozdemir F, Topuz A, Kabas O, Canakci M (2004). Some physical and nutritional properties of Juniperus drupacea fruits. Journal of Food Engineering 65 (3): 325-331. doi: 10.1016/j. jfoodeng.2004.01.029
- Akkol EK, Güvenç A, Yesilada E (2009). A comparative study on the antinociceptive and anti-inflammatory activities of five Juniperus taxa. Journal of Ethnopharmacology 125 (2): 330- 336. doi: 10.1016/j.jep.2009.05.031
- Apak R, Güçlü K, Özyürek M, Karademir SE (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC Method. Journal of Agricultural and Food Chemistry 52 (26): 7970-7981. doi: 10.1021/jf048741x
- Ara KZG, Khan S, Kulkarni TS, Pozzo T, Karlsson EN (2013). Glycoside hydrolases for extraction and modification of polyphenolic antioxidants. Advances in Enzyme Biotechnology 9-21. doi:10.1007/978-81-322-1094-8_2
- Benzie IFF, Strain JJ (1996). The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Analytical Biochemistry 239 (1): 70-76. doi: 10.1006/ ABIO.1996.0292
- Bouayed J, Deußer H, Hoffmann L, Bohn T (2012). Bioaccessible and dialysable polyphenols in selected apple varieties following in vitro digestion vs. their native patterns. Food Chemistry 131(4): 1466-1472. doi: 10.1016/j.foodchem.2011.10.030
- Brand-Williams W, Cuvelier ME, Berset C (1995). Use of a free radical method to evaluate antioxidant activity. LWT - Food Science and Technology 28 (1): 25-30. doi: 10.1016/S0023-6438(95)80008-5
- Brodkorb A, Egger L, Alminger M, Alvito P, Assunção R et al. (2019). INFOGEST static in vitro simulation of gastrointestinal food digestion. Nature Protocols 14 (4): 991-1014. doi: 10.1038/ s41596-018-0119-1
- Cassani L, Gerbino E, Moreira M del R, Gómez-Zavaglia A (2018). Influence of non-thermal processing and storage conditions on the release of health-related compounds after in vitro gastrointestinal digestion of fiber-enriched strawberry juices. Journal of Functional Foods 40: 128-136. doi: 10.1038/s41596- 018-0119-1
- Cervantes L, Martínez-Ferri E, Carrera M, Soria C, Ariza MT (2019). Effectiveness of different depuration procedures in removing reagents interference on in vitro digested strawberry extracts for reliable antioxidant determinations. Journal of Berry Research 9: 473-481. doi: 10.3233/JBR-190385
- Chait YA, Gunenc A, Bendali F, Hosseinian F (2020). Simulated gastrointestinal digestion and in vitro colonic fermentation of carob polyphenols: bioaccessibility and bioactivity. LWT 117: 108623. doi: 10.1016/j.lwt.2019.108623
- Chen GL, Chen SG, Zhao YY, Luo CX, Li J et al. (2014). Total phenolic contents of 33 fruits and their antioxidant capacities before and after in vitro digestion. Industrial Crops and Products 57: 150- 157. doi: 10.1016/j.indcrop.2014.03.018
- Czubinski J, Wroblewska K, Czyzniejewski M, Górnaś P, Kachlicki P et al. (2019). Bioaccessibility of defatted lupin seed phenolic compounds in a standardized static in vitro digestion system. Food Research International 116: 1126-1134. doi: 10.1016/j. foodres.2018.09.057
- Dantas AM, Mafaldo IM, Oliveira PM de L, Lima M dos S, Magnani M et al. (2019). Bioaccessibility of phenolic compounds in native and exotic frozen pulps explored in Brazil using a digestion model coupled with a simulated intestinal barrier. Food Chemistry 274: 202-214. doi: 10.1016/j.foodchem.2018.08.099
- De Morais JS, Sant’Ana AS, Dantas AM, Silva BS, Lima MS et al. (2020). Antioxidant activity and bioaccessibility of phenolic compounds in white, red, blue, purple, yellow and orange edible flowers through a simulated intestinal barrier. Food Research International 131: 109046. doi: 10.1016/j.foodres.2020.109046
- Dutra RLT, Dantas AM, Marques D de A, Batista JDF, Meireles BRL de A et al. (2017). Bioaccessibility and antioxidant activity of phenolic compounds in frozen pulps of Brazilian exotic fruits exposed to simulated gastrointestinal conditions. Food Research International 100: 650-657. doi: 10.1016/j.foodres.2017.07.047
- El-Ghorab A, Shaaban HA, El-Massry KF, Shibamoto T (2008). Chemical composition of volatile extract and biological activities of volatile and less-volatile extracts of juniper berry (Juniperusdrupacea L.) fruit. Journal of Agricultural and Food Chemistry 56 (13): 5021-5025. doi: 10.1021/jf8001747
- Gawlik-Dziki U (2004). Phenolic acids as bioactive compounds in food products. Żywność Nauka Technologia Jakość 4: 29-40.
- Gil-Izquierdo A, Zafrilla P, Tomás-Barberán FA (2002). An in vitro method to simulate phenolic compound release from the food matrix in the gastrointestinal tract. European Food Research and Technology 214 (2): 155-159. doi: 10.1007/s00217-001- 0428-3
- Gonçalves J, Ramos R, Luís Â, Rocha S, Rosado T et al. (2019). Assessment of the bioaccessibility and bioavailability of the phenolic compounds of Prunusavium L. by in vitro digestion and cell model. ACS Omega 4 (4): 7605-7613. doi: 10.1021/ acsomega.8b03499
- Heim KE, Tagliaferro AR, Bobilya DJ (2002). Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. The Journal of Nutritional Biochemistry 13 (10): 572-584. doi: 10.1016/S0955-2863(02)00208-5
- Izgi N (2011). Determination of composition of homemade andiz molasses, reological characteristics, antioxidant and antimicrobical activities.MSc,Namık Kemal University, Graduate School of Natural and Applied Sciences, Department of Food Engineering, Tekirdağ, Turkey.
- Kamiloglu S, Capanoglu E (2014). In vitro gastrointestinal digestion of polyphenols from different molasses (pekmez) and leather (pestil) varieties. International Journal of Food Science and Technology 49 (4): 1027-1039. doi: 10.1111/ijfs.12396
- Kamiloglu S, Pasli AA, Ozcelik B, Van Camp J, Capanoglu E (2015). Influence of different processing and storage conditions on in vitro bioaccessibility of polyphenols in black carrot jams and marmalades. Food Chemistry 186: 74-82. doi: 10.1016/j. foodchem.2014.12.046
- Karababa E, Işikli ND (2005). Pekmez: a traditional concentrated fruit product. Food Reviews International 21 (4): 357-366. doi: 10.1080/87559120500222714
- Karadag A, Ozcelik B, Saner S (2009). Review of methods to determine antioxidant capacities. Food Analytical Methods 2 (1). doi: 10.1007/s12161-008-9067-7
- Kozan E, Küpeli E, Yesilada E (2006). Evaluation of some plants used in Turkish folk medicine against parasitic infections for their in vivo anthelmintic activity. Journal of Ethnopharmacology 108 (2): 211-216. doi: 10.1016/j.jep.2006.05.003
- Lucas-González R, Viuda-Martos M, Pérez Álvarez JA, FernándezLópez J (2018). Changes in bioaccessibility, polyphenol profile and antioxidant potential of flours obtained from persimmon fruit (Diospyros kaki) co-products during in vitro gastrointestinal digestion. Food Chemistry 256: 252-258. doi: 10.1016/j.foodchem.2018.02.128
- Marquardt KC, Watson RR (2014). Polyphenols and public health. In: Watson RR, Preedy VR, Zibadi S (editors). Polyphenols in Human Health and Disease. San Diego, CA, USA: Academic Press, pp. 9-15. doi: 10.1016/C2011-1-09286-X
- Miceli N, Trovato A, Marino A, Bellinghieri V, Melchini A et al. (2011). Phenolic composition and biological activities of Juniperus drupacea Labill. berries from Turkey. Food and Chemical Toxicology 49 (10): 2600-2608. doi: 10.1016/j. fct.2011.07.004
- MiceliN, Marino A, Köroğlu A, Cacciola F, Dugo P et al. (2020). Comparative study of the phenolic profile, antioxidant and antimicrobial activities of leaf extracts of five Juniperus L. (Cupressaceae) taxa growing in Turkey. Natural Product Research 34 (11): 1636-1641. doi: 10.1080/14786419.2018.1523162
- Mikulic‐Petkovsek M, Koron D, Rusjan D (2020). The impact of food processing on the phenolic content in products made from juneberry (Amelanchier lamarckii) fruits. Journal of Food Science 85(2): 386-393. doi: 10.1111/1750-3841.15030
- Minekus M, Alminger M, Alvito P, Ballance S, Bohn Tet al. (2014). A standardised static in vitro digestion method suitable for foodan international consensus. Food and Function 5 (6): 1113-1124. doi: 10.1039/c3fo60702j
- Mosele JI, Macià A, Romero MP, Motilva MJ (2016). Stability and metabolism of Arbutus unedo bioactive compounds (phenolics and antioxidants) under in vitro digestion and colonic fermentation. Food Chemistry 201: 120-130. doi: 10.1016/j. foodchem.2016.01.076
- Nayak B, Liu RH, Tang J (2015). Effect of processing on phenolic antioxidants of fruits, vegetables, and grains—a review. Critical Reviews in Food Science and Nutrition 55 (7): 887-918. doi: 10.1080/10408398.2011.654142
- O’Sullivan AM, O’Callaghan YC, O’Connor TP, O’Brien NM (2013). Comparison of the antioxidant activity of commercial honeys, before and after in-vitro digestion. Polish Journal of Food and Nutrition Sciences 63 (3): 167-171. doi: 10.2478/v10222-012- 0080-6
- Orhan DD, Orhan N, Gökbulut A (2019). In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical studies on Juniperus drupacea. Marmara Pharmaceutical Journal 23 (1): 83- 92. doi: 10.12991/jrp.2018.112
- Orhan N, Orhan IE, Ergun F (2011). Insights into cholinesterase inhibitory and antioxidant activities of five Juniperus species. Food and Chemical Toxicology 49 (9): 2305-2312. doi: 10.1016/j. fct.2011.06.031
- Orjuela-Palacio JM, Zamora MC, Lanari MC (2019).Physicochemical and dynamic sensory characterization of a Yerba mate/ Blackcurrant instant beverage powder rich in natural antioxidants. Journal of Berry Research 9: 195-208. doi: 10.3233/JBR-180342
- Re R, Pellegrini N, Proteggente A, Pannala A, Yang M et al. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine 26 (9- 10): 1231-1237. doi: 10.1016/S0891-5849(98)00315-3
- Seca AML, Pinto PCGA, Silva AMS (2015).The current status of bioactive metabolites from the genus Juniperus. Bioactive Phytochemicals: Perspectives for Modern Medicine 3: 365-408.
- Semiz G, Isik K, Unal O (2007). Enek pekmez production from Juniper “Fruits” by native people on the Taurus Mountains in Southern Turkey. Economic Botany 61 (3): 299-301.
- Seraglio SKT, Valese AC, Daguer H, Bergamo G, Azevedo MS et al. (2017). Effect ofin vitrogastrointestinal digestion on the bioaccessibility of phenolic compounds, minerals, and antioxidant capacity of Mimosa scabrella Bentham honeydew honeys. Food Research International 99 (Part 1): 670-678. doi: 10.1016/j.foodres.2017.06.024
- Silva GG, Dutra MDCP, De Oliveira JB, Rybka ACP, Pereira GE et al. (2019). Processing methods with heat increases bioactive phenolic compounds and antioxidant activity in grape juices. Journal of Food Biochemistry 43 (3): 12732. doi: 10.1111/ jfbc.12732
- Singleton VL, Orthofer R, Lamuela-Raventós E (1999). Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Methods in Enzymology 299: 152-178. doi: 10.1016/S0076-6879(99)99017-1
- Suna S (2019). Effects of hot air, microwave and vacuum drying on drying characteristics and in vitro bioaccessibility of medlar fruit leather (pestil). Food Science and Biotechnology 28 (5): 1465-1474. doi: 10.1007/s10068-019-00588-7
- Tagliazucchi D, Verzelloni E, Bertolini D, Conte A (2010). In vitro bio-accessibility and antioxidant activity of grape polyphenols. Food Chemistry 120 (2): 599-606. doi: 10.1016/j. foodchem.2009.10.030
- Tamer CE, Temel SG, Suna S, Karabacak Ozkan A, Ozcan T et al. (2021). Evaluation of bioaccessibility and functional properties of kombucha beverages fortified with different medicinal plant extracts. Turkish Journal of Agriculture and Forestry 45: 13-32. doi: 10.3906/tar-2003-75
- Tomas M, Sağdıç O, Çatalkaya G, Kahveci D, Çapanoğlu E (2019). Effects of cooking and extra virgin olive oil addition on bioaccessibility of carotenes in tomato sauce. Turkish Journal of Agriculture and Forestry 43: 478-484. doi: 10.3906/tar-1801- 127
- Taviano MF, Marino A, Trovato A, Bellinghieri V, La Barbera TM et al. (2011). Antioxidant and antimicrobial activities of branches extracts of five Juniperus species from Turkey. Pharmaceutical Biology 49 (10): 1014-1022. doi: 10.3109/13880209.2011.560161
- Tomas-Barberan FA, Selma MV, Espín JC (2018). Polyphenols’ gut microbiota metabolites: bioactives or biomarkers? Journal of Agricultural and Food Chemistry 66 (14): 3593-3594. doi: 10.1021/acs.jafc.8b00827
- Ucar TM, Karadag A (2019). The effects of vacuum and freeze-drying on the physicochemical properties and in vitro digestibility of phenolics in oyster mushroom (Pleurotusostreatus). Journal of Food Measurement and Characterization 13 (3): 2298-2309. doi: 10.1007/s11694-019-00149-w
- Uzunović A, Vranić E (2008). stability of anthocyanins from commercial black currant juice under simulated gastrointestinal digestion. Bosnian Journal of Basic Medical Sciences 8 (3): 254-258. doi: 10.17305/bjbms.2008.2928
- Yeşilada E, Honda G, Sezik E, Tabata M, Goto K et al. (1993). Traditional medicine in Turkey IV. Folk medicine in the Mediterranean subdivision. Journal of Ethnopharmacology 39 (1): 31-38. doi: 10.1016/0378-8741(93)90048-A
- Zhishen J, Mengcheng T, Jianming W (1999). The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chemistry 64 (4): 555-559. doi: 10.1016/S0308-8146(98)00102-2
| APA | OZKAN K, KARADAG A, SAGDIC O (2021). Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. , 290 - 300. 10.3906/tar-2009-2 |
| Chicago | OZKAN KUBRA,KARADAG AYSE,SAGDIC OSMAN Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. (2021): 290 - 300. 10.3906/tar-2009-2 |
| MLA | OZKAN KUBRA,KARADAG AYSE,SAGDIC OSMAN Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. , 2021, ss.290 - 300. 10.3906/tar-2009-2 |
| AMA | OZKAN K,KARADAG A,SAGDIC O Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. . 2021; 290 - 300. 10.3906/tar-2009-2 |
| Vancouver | OZKAN K,KARADAG A,SAGDIC O Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. . 2021; 290 - 300. 10.3906/tar-2009-2 |
| IEEE | OZKAN K,KARADAG A,SAGDIC O "Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez." , ss.290 - 300, 2021. 10.3906/tar-2009-2 |
| ISNAD | OZKAN, KUBRA vd. "Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez". (2021), 290-300. https://doi.org/10.3906/tar-2009-2 |
| APA | OZKAN K, KARADAG A, SAGDIC O (2021). Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. Turkish Journal of Agriculture and Forestry, 45(3), 290 - 300. 10.3906/tar-2009-2 |
| Chicago | OZKAN KUBRA,KARADAG AYSE,SAGDIC OSMAN Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. Turkish Journal of Agriculture and Forestry 45, no.3 (2021): 290 - 300. 10.3906/tar-2009-2 |
| MLA | OZKAN KUBRA,KARADAG AYSE,SAGDIC OSMAN Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. Turkish Journal of Agriculture and Forestry, vol.45, no.3, 2021, ss.290 - 300. 10.3906/tar-2009-2 |
| AMA | OZKAN K,KARADAG A,SAGDIC O Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. Turkish Journal of Agriculture and Forestry. 2021; 45(3): 290 - 300. 10.3906/tar-2009-2 |
| Vancouver | OZKAN K,KARADAG A,SAGDIC O Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez. Turkish Journal of Agriculture and Forestry. 2021; 45(3): 290 - 300. 10.3906/tar-2009-2 |
| IEEE | OZKAN K,KARADAG A,SAGDIC O "Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez." Turkish Journal of Agriculture and Forestry, 45, ss.290 - 300, 2021. 10.3906/tar-2009-2 |
| ISNAD | OZKAN, KUBRA vd. "Determination of the in vitro bioaccessibility of phenolic compounds and antioxidant capacity of Juniper berry (Juniperus drupacea Labill.) pekmez". Turkish Journal of Agriculture and Forestry 45/3 (2021), 290-300. https://doi.org/10.3906/tar-2009-2 |
