The uses of platelet indices, NLR (Neutrophil to
Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio)
in the predictive value diagnosis of benign and malignant
masses of the parotid gland

Tan, Mehmet; Aslan, Mehmet

doi:10.5455/annalsmedres.2021.04.331

The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland

Mehmet ASLAN, (İnönü Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Malatya, Türkiye)

Mehmet TAN (İnönü Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Malatya, Türkiye)

Annals of Medical Research

1 0

Yıl: 2021 Cilt: 28 Sayı: 12 Sayfa Aralığı: 2224 - 2230 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2021.04.331 İndeks Tarihi: 06-06-2022

The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland

Öz:

Aim: Parotid gland tumors are uncommon in the head and neck surgery practice and difficult to surgically treat. Planning is very important, especially while planning parotid gland surgery, considering the difficulty of revision surgery. In this context, fine-needle aspiration cytology and radiological imaging stand out. However, preoperative diagnosis is sometimes difficult due to the nature of the salivary gland. At this point, additional methods in preoperative diagnosis are questioned. In our study, it was aimed to determine the surgical modality based on the predictive value in parotid benign and malignant masses with inexpensive, fast and easily obtainable platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio). Materials and Methods: The data of 236 patients who were operated on with parotid masses between 2010 and 2020 in our clinic were retrospectively analyzed. The data of the patients and the control group were evaluated statistically. Results: A total of 356 participants were included in the study, including 236 patients who had undergone parotid gland surgery and a control group of 120 healthy individuals. When the data of the participants were reviewed, there was no significant difference between the groups in terms of age. In terms of sex, the number of the male patients was significantly higher than the female participants in the group with only parotid benign neoplasia. Based on the collected data, the mean MPV (Mean Platelet Volume) values were mean 9.1548 ± 1.55152 in the parotid cancer patient group (n1), 9.3810 ± 1.57825 in the inpatient group with parotid benign mass (n2) and 10.49250± 1.05314 in the control group (n3). The mean NLR values were found as 3.6395 ± 3.36035 in the parotid cancer patients (n1), 2.0145 ± 1.04293 in the parotid benign masses (n2) and 1.9689 ± 1.54979 in the control group (n3). The mean PDW (Platelet Distribution Width) values were found as 14.1258 ± 2.82536 in the parotid cancer patient group (n1), 14.5220 ± 2.69823 in the parotid benign mass group (n2), and 12.5150 ± 2.49953 in the control group (n3). Conclusion: In our study, we observed that the MPV, PDW and NLR values were significantly changed in the parotid gland tumors. We concluded that NLR values may be used effectively, especially in the predictive diagnosis of malignant masses and in planning surgery.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Stryjewska-Makuch G, Kolebacz B, Janik MA, et al. Increase in the incidence of parotid gland tumors in the years 2005-2014. Otolaryngol Pol 2017;71:29-34.
2. Sowa P, Misiolek M, Pasinski B, et al. Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study. Biomed Res Int. 2018;2018:4340871. Published 2018.
3. Damar M, Dinç AE, Erdem D, et al. Pretreatment Neutrophil-Lymphocyte Ratio in Salivary Gland Tumors Is Associated with Malignancy. Otolaryngol Head Neck Surg 2016;155:988-96.
4. Kuzucu I, Guler I, Kum RO, et al. Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors. Braz J Otorhinolaryngol 2020;86:105-110.
5. Jones AV, Craig GT, Speight PM, et al. The range and demographics of salivary gland tumours diagnosed in a UK population. Oral Oncol 2008;44:407-17.
6. Zhan KY, Khaja SF, Flack AB, et al. Benign Parotid Tumors. Otolaryngol Clin North Am 2016;49:327-42.
7. Xie S, Wang K, Xu H, et al. PRISMA-Extracapsular Dissection Versus Superficial Parotidectomy in Treatment of Benign Parotid Tumors: Evidence From 3194 Patients. Medicine (Baltimore) 2015;94:e1237.
8. Bailey H. The surgical anatomy of the parotid gland. Br Med J 1948;2:245-8.
9. Janes RM. The Treatment of Tumours of the Salivary Glands by Radical Excision. Can Med Assoc J 1940;43:554-9.
10. Mascarella MA, Mannard E, Silva SD, et al. Neutrophilto-lymphocyte ratio in head and neck cancer prognosis: A systematic review and meta-analysis. Head Neck 2018;40:1091-100.
11. Sowa P, Misiolek M, Zielinski M, et al. Novel interleukin-33 and its soluble ST2 receptor as potential serum biomarkers in parotid gland tumors. Exp Biol Med (Maywood) 2018;243:762-9.
12. Sowa P, Misiolek M, Zielinski M, et al. Novel interleukin-33 and its soluble ST2 receptor as potential serum biomarkers in parotid gland tumors. Exp Biol Med (Maywood) 2018;243:762-9.
13. Ihrler S, Guntinas-Lichius O, Haas C, et al. Neues zu Tumoren der Speicheldrüsen : WHO-Klassifikation 2017 [Updates on tumours of the salivary glands : 2017 WHO classification]. Pathologe 2018;39:11-7.
14. Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med 2013;19:1423-37.
15. Teramukai S, Kitano T, Kishida Y, et al. Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer 2009;45:1950-8.
16. Di Carlo E, Forni G, Lollini P, et al. The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood 2001;97:339-45.
17. Ji H, Houghton AM, Mariani TJ, et al. K-ras activation generates an inflammatory response in lung tumors. Oncogene 2006;25:2105-12.
18. Cools-Lartigue J, Spicer J, McDonald B, et al. Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis [published online ahead of print, 2013 Jul 1]. J Clin Invest 2013;123:3446-58.
19. Park J, Wysocki RW, Amoozgar Z, et al. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med 2016;8:361ra138.
20. Gregory AD, Houghton AM. Tumor-associated neutrophils: new targets for cancer therapy. Cancer Res 2011;71:2411-6.
21. Dumitru CA, Moses K, Trellakis S, et al. Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology. Cancer Immunol Immunother 2012;61:1155-67.
22. Yamanaka T, Matsumoto S, Teramukai S, et al. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007;73:215-20.
23. Liu CL, Lee JJ, Liu TP, et al. Blood neutrophil-tolymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. J Surg Oncol 2013;107:493-7.
24. Wee JL, Greenwood DL, Han X, et al. Inflammatory cytokines IL-6 and TNF-α regulate lymphocyte trafficking through the local lymph node. Vet Immunol Immunopathol 2011;144:95-103.
25. Haghshenas MR, Khademi B, Ashraf MJ, et al. Helper and cytotoxic T-cell subsets (Th1, Th2, Tc1, and Tc2) in benign and malignant salivary gland tumors. Oral Dis 2016;22:566-72.
26. Shau HY, Kim A. Suppression of lymphokineactivated killer induction by neutrophils. J Immunol 1988;141:4395-402.
27. Seng D, Fang Q, Li P, et al. Prognostic Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Pediatric Parotid Cancer. Front Pediatr 2019;7:207. Published 2019.
28. Gao H, Gao Q, Sun J. Significance of Pretreatment Neutrophil-to-Lymphocyte Ratio in Mucoepidermoid Carcinoma of Pediatrics: A Multicenter Study. Front Pediatr 2020;8:96. Published 2020.
29. Baldane S, Ipekci SH, Sozen M, et al. Mean platelet volume could be a possible biomarker for papillary thyroid carcinomas. Asian Pac J Cancer Prev 2015;16:2671-4.
30. Dincel O, Bayraktar C. Evaluation of platelet indices as a useful marker in papillary thyroid carcinoma. Bratisl Lek Listy 2017;118:153-5.
31. Oncel M, Kiyici A, Oncel M, et al. Evaluation of Platelet Indices in Lung Cancer Patients. Asian Pac J Cancer Prev 2015;16:7599-602.
32. Coupland LA, Parish CR. Platelets, selectins, and the control of tumor metastasis. Semin Oncol 2014;41:422-34.
33. Tuncel T, Ozgun A, Emirzeoglu L, et al. Mean platelet volume as a prognostic marker in metastatic colorectal cancer patients treated with bevacizumabcombined chemotherapy. Asian Pac J Cancer Prev 2014;15:6421-3.
34. Alsweedan SA, Al-Shurman A, Mahmoud AS. Diagnostic value of platelet indices in children with leukemia. J Pediatr Hematol Oncol 2008;30:953-55.
35. Kutluturk F, Gul SS, Sahin S, et al. Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma. Endocr Metab Immune Disord Drug Targets 2019;19:859-65.

APA	Aslan M, Tan M (2021). The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . , 2224 - 2230. 10.5455/annalsmedres.2021.04.331
Chicago	Aslan Mehmet,Tan Mehmet The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . (2021): 2224 - 2230. 10.5455/annalsmedres.2021.04.331
MLA	Aslan Mehmet,Tan Mehmet The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . , 2021, ss.2224 - 2230. 10.5455/annalsmedres.2021.04.331
AMA	Aslan M,Tan M The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . . 2021; 2224 - 2230. 10.5455/annalsmedres.2021.04.331
Vancouver	Aslan M,Tan M The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . . 2021; 2224 - 2230. 10.5455/annalsmedres.2021.04.331
IEEE	Aslan M,Tan M "The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland ." , ss.2224 - 2230, 2021. 10.5455/annalsmedres.2021.04.331
ISNAD	Aslan, Mehmet - Tan, Mehmet. "The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland ". (2021), 2224-2230. https://doi.org/10.5455/annalsmedres.2021.04.331

APA	Aslan M, Tan M (2021). The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . Annals of Medical Research, 28(12), 2224 - 2230. 10.5455/annalsmedres.2021.04.331
Chicago	Aslan Mehmet,Tan Mehmet The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . Annals of Medical Research 28, no.12 (2021): 2224 - 2230. 10.5455/annalsmedres.2021.04.331
MLA	Aslan Mehmet,Tan Mehmet The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . Annals of Medical Research, vol.28, no.12, 2021, ss.2224 - 2230. 10.5455/annalsmedres.2021.04.331
AMA	Aslan M,Tan M The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . Annals of Medical Research. 2021; 28(12): 2224 - 2230. 10.5455/annalsmedres.2021.04.331
Vancouver	Aslan M,Tan M The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland . Annals of Medical Research. 2021; 28(12): 2224 - 2230. 10.5455/annalsmedres.2021.04.331
IEEE	Aslan M,Tan M "The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland ." Annals of Medical Research, 28, ss.2224 - 2230, 2021. 10.5455/annalsmedres.2021.04.331
ISNAD	Aslan, Mehmet - Tan, Mehmet. "The uses of platelet indices, NLR (Neutrophil to Lymphocyte Ratio) and PLR (Platelet to Lymphocyte Ratio) in the predictive value diagnosis of benign and malignant masses of the parotid gland ". Annals of Medical Research 28/12 (2021), 2224-2230. https://doi.org/10.5455/annalsmedres.2021.04.331