TY  - JOUR
TI  - Life saving effect of early use of convalescent plasma in
Covid-19 treatment
AB  - Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, which is detected by the transmission from bat to person in Wuhan
Province of China, has shown its effect all over the world in a very short time. There is no treatment method proven effective in
Coronavirus disease 2019 (COVID-19) pandemics. The whole world is still working on it.
Convalescent Plasma (CP) treatment is a passive antibody treatment that has been shown to be effective during periods of epidemic
disease in history. CP treatment is interesting in the treatment of virus infection without vaccine or specific treatment, such as SARSCoV-2, which causes COVID-19.
The mechanisms of action of CP include neutralizing the virus by direct binding, initiating virus elimination by complement activation,
antibody-dependent cellular cytotoxicity and / or phagocytosis. Neutralizing antibodies are the most important mechanisms of
action. The most important point in recovery is the inactivation of the virus and the prevention of viral replication.
It was demonstrated for the first time that CP significantly reduced mortality in COVID-19 disease. Our results of CP treatment in
COVID-19 patients have been published. We have shown that CP is effective and safe in COVID-19 disease. We aimed to gather CP
experiences up to date in COVID-19.
AU  - Biçim, Soykan
AU  - KUKU, IRFAN
AU  - SARICI, AHMET
AU  - BERBER, Ilhami
AU  - Kaya, Emin
AU  - Özgül, Mustafa
AU  - ERKURT, MEHMET ALI
DO  - 10.5455/annalsmedres.2021.03.228
PY  - 2021
JO  - Annals of Medical Research
VL  - 28
IS  - 12
SN  - 2636-7688
SP  - 2242
EP  - 2247
DB  - TRDizin
UR  - http://search/yayin/detay/514743
ER  -