TY  - JOUR
TI  - Polymer–matrix composites
AB  - The aim of this study is to determine whether Platanus orientalis (PO) which has anti-inflammatory,
antioxidant and diuretic properties and used in the treatment of kidney stones as traditional folk medicine, will reduce
or prevent the stone formation in the urinary system. To simulate the urolithiasis model 0.75% ethylene glycol (EG) and
1% ammonium chloride (AC) were applied to Sprague-Dawley rats. The rats were divided into four groups (n=8). The
control group was given standard drinking water for 5 weeks. EG group received 0.75% EG in their drinking water
containing 0.75% EG and 1% AC. PO extract (100 mg/kg) was given orally for 5 weeks to the preventive group and for
last 2 weeks to the therapeutic group, respectively. At the end of experiment, 24-hour urine and kidney samples were
obtained. In urine samples, calcium and citrate levels were decreased and oxalate level was increased in the EG group.
In kidney samples myeloperoxidase, caspase-3, N-acetyl-β-glycosaminidase (NAG) activities, malondialdehyde
(MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), tumor necrosis factor-α and interleukin-1β levels were increased
while superoxide dismutase activity and glutathione levels were decreased in the EG group. These biochemical
parameters returned to control levels in both PO treatment groups. Histological findings also correlate with these
results. Our findings are suggested that PO treatments is effective in both preventive and therapeutic groups.
AU  - ÇEVİK, Özge
AU  - ERDOĞAN, ÖMER
AU  - ADAKUL, Betül AYAZ
AU  - ŞEN, ALİ
AU  - EKER, Pınar
AU  - ÇETİNEL, Şule
AU  - ŞENER, Göksel
AU  - ŞENER, T. Emre
AU  - ŞENKARDEŞ, İsmail
AU  - ERTAS, BÜSRA
AU  - BÖLÜKBAŞI, Furkan
DO  - 10.29228/jrp.129
PY  - 2022
JO  - Journal of research in pharmacy (online)
VL  - 26
IS  - 2
SN  - 2630-6344
SP  - 311
EP  - 324
DB  - TRDizin
UR  - http://search/yayin/detay/514858
ER  -