TY  - JOUR
TI  - Evaluation of C-reactive protein levels in the differentiation of non-alcoholic steatohepatitis and simple liver steatosis
AB  - Objective:
Non-alcoholic fatty liver disease (NAFLD) is a broad-spectrum disease that has increased in
recent years due to increased sedentary life and obesity. It was aimed to determine C-reactive
protein (CRP) levels, its association with simple steatosis and non-alcoholic steatohepatitis
(NASH) and its diagnostic value in this study.
Methods:
A total of 165patients who had a diagnosis of fatty liver disease (simple steatosis group and
NASH group) and 99 healthy controls without liver disease were included in the study. Aspartate
aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, direct bilirubin, CRP
levels were evaluated and ultrasonographic evaluation of liver was performed in all groups.
Histopathological evaluation was performed by biopsy in 65 patients who were thought to have
NASH.
Results:
AST and ALT values were found to be significantly higher in the NASH group than the other
groups. CRP levels were detected lowest in control group and highest in NASH group (p
<0.001). AST values were also significantly higher in patients with fibrosis grade 3-4 compared
to the control group.
Conclusion:
Our study showed that CRP level is a suitable marker for differentiation of simple steatosis and
NASH.
AU  - Gunay, Suleyman
AU  - Adanir, Haydar
AU  - Pakoz, Zehra Betul
DO  - 10.53394/akd.976570
PY  - 2022
JO  - Akdeniz Tıp Dergisi
VL  - 8
IS  - 2
SN  - 1300-1779
SP  - 202
EP  - 207
DB  - TRDizin
UR  - http://search/yayin/detay/514879
ER  -