Formulation and characterization of mometasone furoate
and formoterol fumarate containing dry powder inhaler
by spray drying and homogenization methods

GULSUN, Tugba; AKDAG, Yagmur; IZAT, Nihan; ONER, Levent; SAHIN, Selma

doi:10.29228/jrp.136

Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods

Yagmur AKDAG, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Tugba GULSUN, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Nihan IZAT, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Levent ONER, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Selma SAHIN (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Journal of research in pharmacy (online)

11 0

Yıl: 2022 Cilt: 26 Sayı: 2 Sayfa Aralığı: 383 - 396 Metin Dili: İngilizce DOI: 10.29228/jrp.136 İndeks Tarihi: 07-06-2022

Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods

Öz:

This study aimed to design and characterize an inhalable dry powder of mometasone furoate monohydrate (MFM) combined with the formoterol fumarate dihydrate (FFD). Homogenization in water and spray drying processes were used to prepare the dry powders for inhalation. The physicochemical characteristics of the dry powders were evaluated by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The particle size distribution, content uniformity, solid behavior and aerodynamic properties of DPI were also determined. After the micronization process, the particle sizes of the raw materials significantly decreased. SEM images implied that FFD covered the MFM surface during the spray drying step, and uniform particles were produced. X-ray and DSC results demonstrated that MFM did not show any change in crystal structure after homogenization and spray drying processes. DSC analysis of DPI formulation exhibited that the same melting point of MFM was observed when the drugs were spray dried. FT-IR spectra exhibited the characteristic peaks for MFM in DPI formulation. Content uniformity results showed that the developed production method is suitable for manufacturing uniform formulations. According to angle of repose, Hausner ratio and Carr’s index results, DPI formulation has preferable flow properties. In addition, emitted dose, mass median aerodynamic diameter, fine particle fraction showed that the DPI formulation could ensure drug delivery to the alveoli. This study showed that the combination of homogenization and spray drying methods is suitable to obtain a DPI formulation containing MFM and FFD with a particle size less than 5 μm to reach alveoli.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AKDAG Y, GULSUN T, IZAT N, ONER L, SAHIN S (2022). Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. , 383 - 396. 10.29228/jrp.136
Chicago	AKDAG Yagmur,GULSUN Tugba,IZAT Nihan,ONER Levent,SAHIN Selma Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. (2022): 383 - 396. 10.29228/jrp.136
MLA	AKDAG Yagmur,GULSUN Tugba,IZAT Nihan,ONER Levent,SAHIN Selma Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. , 2022, ss.383 - 396. 10.29228/jrp.136
AMA	AKDAG Y,GULSUN T,IZAT N,ONER L,SAHIN S Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. . 2022; 383 - 396. 10.29228/jrp.136
Vancouver	AKDAG Y,GULSUN T,IZAT N,ONER L,SAHIN S Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. . 2022; 383 - 396. 10.29228/jrp.136
IEEE	AKDAG Y,GULSUN T,IZAT N,ONER L,SAHIN S "Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods." , ss.383 - 396, 2022. 10.29228/jrp.136
ISNAD	AKDAG, Yagmur vd. "Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods". (2022), 383-396. https://doi.org/10.29228/jrp.136

APA	AKDAG Y, GULSUN T, IZAT N, ONER L, SAHIN S (2022). Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. Journal of research in pharmacy (online), 26(2), 383 - 396. 10.29228/jrp.136
Chicago	AKDAG Yagmur,GULSUN Tugba,IZAT Nihan,ONER Levent,SAHIN Selma Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. Journal of research in pharmacy (online) 26, no.2 (2022): 383 - 396. 10.29228/jrp.136
MLA	AKDAG Yagmur,GULSUN Tugba,IZAT Nihan,ONER Levent,SAHIN Selma Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. Journal of research in pharmacy (online), vol.26, no.2, 2022, ss.383 - 396. 10.29228/jrp.136
AMA	AKDAG Y,GULSUN T,IZAT N,ONER L,SAHIN S Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. Journal of research in pharmacy (online). 2022; 26(2): 383 - 396. 10.29228/jrp.136
Vancouver	AKDAG Y,GULSUN T,IZAT N,ONER L,SAHIN S Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods. Journal of research in pharmacy (online). 2022; 26(2): 383 - 396. 10.29228/jrp.136
IEEE	AKDAG Y,GULSUN T,IZAT N,ONER L,SAHIN S "Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods." Journal of research in pharmacy (online), 26, ss.383 - 396, 2022. 10.29228/jrp.136
ISNAD	AKDAG, Yagmur vd. "Formulation and characterization of mometasone furoate and formoterol fumarate containing dry powder inhaler by spray drying and homogenization methods". Journal of research in pharmacy (online) 26/2 (2022), 383-396. https://doi.org/10.29228/jrp.136