Objective: To evaluate the etiological, clinical and laboratory characteristics of children followed up with the diagnosis of acute pancreatitis (AP). Material and Methods: Children <19 years of age, who were followed up in our unit for AP between 2005 and 2021, were included in the study. Cases with at least 2 of the 3 criteria determined by the International Pediatric Pancreatitis Study Group were accepted as AP. The demographic, clinical, etiological, characteristics, treatment methods, course and complication characteristics of the patients were analyzed from their files, retrospectively. Results: A total of 46 patients, 22 (47.8%) female, who met the criteria were included in the study. The mean age of the patients was 10.08±4.90 years. The most common complaint was abdominal pain (80.44%). Other complaints were 30.44% nausea and vomiting, 15.2% fever and 6.5% jaundice. No etiologic cause was found in a significant part of the patients (36.9%) (idiopathic). Other causes were pancreatobiliary (23.9%), trauma (19.6%), infectious (8.7%), systemic disease (diabetic ketoacidosis and hemolytic uremic syndrome) and drug (valproic acid) use. In 50% of trauma patients, the cause was the crush of bicycle handlebar. In the group with a hospital stay >7 days, the leukocyte value was higher, calcium and albumin were lower, and the initiation time of enteral nutrition was longer. Transaminase values were higher in the non-biliary group, and gamma glutamyl transferase and bilirubin values were higher in the biliary group. Conclusion: AP, the frequency of diagnosis of which has increased in recent years with the developing imaging methods, should be considered in the differential diagnosis of patients with the most complaints of abdominal pain and vomiting. Leukocytosis, hypoalbuminemia and hypocalcemia are poor prognostic factors. Early initiation of enteral feeding will reduce the length of hospital stay and complications.