TY  - JOUR
TI  - Synthesis, antioxidant and carbonic anhydrase inhibitory
properties of monopeptide-anthraquinone conjugates
AB  - Novel monopeptide-anthraquinone conjugates (1-16) were synthesized by the reaction of appropriate
N-protected amino acid with 2-hydroxymethylanthraquinone in good or high yields. The structural elucidation of
the new compounds was accomplished by 1H NMR,
13C NMR, MS, FT-IR spectroscopy and elemental analysis
techniques. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity of the new compounds was determined
against two human (h) isoforms, hCA I and hCA II. While three of the sixteen compounds showed moderate in
vitro carbonic anhydrase inhibitory properties against hCA II with inhibition constants in the micromolar level
(43.5, 67.4 and 78.1 µM), they did not show inhibitory activity against hCA I up to 100 µM concentration. The
antioxidant abilities of the compounds were determined using the 1,1-diphenyl-2-picrylhydrazil (DPPH) radical
scavenging method, ferric ion reducing assay and metal chelation methods. While a small amount of
antioxidant activity was observed according to the DPPH and ferric ion reducing power assay methods,
none of the compounds showed antioxidant properties according to the metal chelating activity method
at the concentrations studied.
AU  - Kucukbay, Hasan
AU  - angeli, andrea
AU  - Küçükbay, F. Zehra
AU  - Bartolucci, Gianluca
AU  - Supuran, Claudiu
AU  - Parladı, Fatma Müzeyyen
DO  - 10.25135/acg.oc.108.2107.2126
PY  - 2021
JO  - Organic Communications
VL  - 14
IS  - 3
SN  - 1307-6175
SP  - 255
EP  - 269
DB  - TRDizin
UR  - http://search/yayin/detay/515661
ER  -