Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition
Yıl: 2021 Cilt: 14 Sayı: 3 Sayfa Aralığı: 270 - 279 Metin Dili: İngilizce DOI: 10.25135/acg.oc.109.2107.2140 İndeks Tarihi: 08-06-2022
Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition
Öz: The carbazole skeleton is the key structural motif of many bioactive molecules including synthetic and
natural products. The carbazole derivatives bearing different functional groups have important pharmacological
activities and are widely used in medicine and pharmacology. Ethyl 9H-carbazol-9-yl acetate was synthesized from
the reaction of the carbazole with ethyl bromoacetate. The acetate ester derivative was converted into the 2-(9Hcarbazol-9-yl) acetohydrazide through treatment with hydrazine hydrate. The target compounds were synthesized by
using carbazole-hydrazides and various aromatic acid chlorides. Acetyl benzohydrazide derivatives were prepared
from the nucleophilic addition-elimination reactions of corresponding benzoyl chloride and 2-(9H-carbazol-9-yl)
acetohydrazide in THF at room temperature condition. The structures of all newly synthesized compounds were
characterized using different spectroscopic techniques, such as FT-IR, 1H NMR, 13C NMR, and HRMS. The urease
enzyme activities of these compounds were investigated using Jack bean urease as the model enzyme.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ÇAPAN I (2021). Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. , 270 - 279. 10.25135/acg.oc.109.2107.2140 |
| Chicago | ÇAPAN IRFAN Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. (2021): 270 - 279. 10.25135/acg.oc.109.2107.2140 |
| MLA | ÇAPAN IRFAN Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. , 2021, ss.270 - 279. 10.25135/acg.oc.109.2107.2140 |
| AMA | ÇAPAN I Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. . 2021; 270 - 279. 10.25135/acg.oc.109.2107.2140 |
| Vancouver | ÇAPAN I Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. . 2021; 270 - 279. 10.25135/acg.oc.109.2107.2140 |
| IEEE | ÇAPAN I "Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition." , ss.270 - 279, 2021. 10.25135/acg.oc.109.2107.2140 |
| ISNAD | ÇAPAN, IRFAN. "Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition". (2021), 270-279. https://doi.org/10.25135/acg.oc.109.2107.2140 |
| APA | ÇAPAN I (2021). Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. Organic Communications, 14(3), 270 - 279. 10.25135/acg.oc.109.2107.2140 |
| Chicago | ÇAPAN IRFAN Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. Organic Communications 14, no.3 (2021): 270 - 279. 10.25135/acg.oc.109.2107.2140 |
| MLA | ÇAPAN IRFAN Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. Organic Communications, vol.14, no.3, 2021, ss.270 - 279. 10.25135/acg.oc.109.2107.2140 |
| AMA | ÇAPAN I Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. Organic Communications. 2021; 14(3): 270 - 279. 10.25135/acg.oc.109.2107.2140 |
| Vancouver | ÇAPAN I Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition. Organic Communications. 2021; 14(3): 270 - 279. 10.25135/acg.oc.109.2107.2140 |
| IEEE | ÇAPAN I "Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition." Organic Communications, 14, ss.270 - 279, 2021. 10.25135/acg.oc.109.2107.2140 |
| ISNAD | ÇAPAN, IRFAN. "Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition". Organic Communications 14/3 (2021), 270-279. https://doi.org/10.25135/acg.oc.109.2107.2140 |
