Acute hyperglycemia causes oxidative stress which is
prevented by vitamin E pretreatment in healthy rabbits

TELLI, GOKÇEN; KAZKAYASI, İnci; UMA, Serdar; BALCI, Aylin

doi:10.29228/jrp.150

Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits

İnci KAZKAYASI, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, Ankara, Türkiye.)

Gökçen TELLİ, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, Ankara, Türkiye.)

Serdar UMA, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, Ankara, Türkiye.)

Aylin BALCI (Hacettepe Üniversitesi Eczacılık Fakültesi Toksikoloji Anabilim Dalı, Ankara, Türkiye.)

Journal of research in pharmacy (online)

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Yıl: 2022 Cilt: 26 Sayı: 3 Sayfa Aralığı: 534 - 542 Metin Dili: İngilizce DOI: 10.29228/jrp.150 İndeks Tarihi: 08-06-2022

Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits

Öz:

Although there are many studies showing chronic hyperglycemia in diabetes increases oxidative stress, those examining the influence of acute glucose increase are limited. The aim of this study was to investigate the effect of acute hyperglycemia on oxidative stress markers in non-treated and vitamin E pretreated healthy rabbits. Acute hyperglycemia was induced by oral glucose administration (1g/kg). Before and at different time points up to 180 minutes following the administration, blood samples were collected to measure malondialdehyde and glutathione spectrophotometrically as oxidative stress and antioxidant capacity markers respectively. Same markers were also determined in kidney and liver homogenates. There was no difference in glucose tolerance between non-treated and vitamin E pre-treated groups (p=0.10). Plasma malondialdehyde levels were increased after glucose administration in both groups. There was a positive-correlation between blood glucose and plasma malondialdehyde in non-treated (r=+0.447; p=0.008) but not in vitamin E pre-treated group (r=0.076; p=0.361). Plasma glutathione levels were higher in vitamin E pre-treated group at all-time points compared to non-treated group (p<0.05). There was a negative-correlation between blood glucose and plasma glutathione levels in non-treated (r=- 0.357; p=0.033) but not in vitamin E pre-treated group (r=0.007; p=0.485). According to our results acute hyperglycemia provokes oxidative stress which is partially prevented by vitamin E pretreatment.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KAZKAYASI İ, TELLI G, UMA S, BALCI A (2022). Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. , 534 - 542. 10.29228/jrp.150
Chicago	KAZKAYASI İnci,TELLI GOKÇEN,UMA Serdar,BALCI Aylin Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. (2022): 534 - 542. 10.29228/jrp.150
MLA	KAZKAYASI İnci,TELLI GOKÇEN,UMA Serdar,BALCI Aylin Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. , 2022, ss.534 - 542. 10.29228/jrp.150
AMA	KAZKAYASI İ,TELLI G,UMA S,BALCI A Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. . 2022; 534 - 542. 10.29228/jrp.150
Vancouver	KAZKAYASI İ,TELLI G,UMA S,BALCI A Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. . 2022; 534 - 542. 10.29228/jrp.150
IEEE	KAZKAYASI İ,TELLI G,UMA S,BALCI A "Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits." , ss.534 - 542, 2022. 10.29228/jrp.150
ISNAD	KAZKAYASI, İnci vd. "Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits". (2022), 534-542. https://doi.org/10.29228/jrp.150

APA	KAZKAYASI İ, TELLI G, UMA S, BALCI A (2022). Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. Journal of research in pharmacy (online), 26(3), 534 - 542. 10.29228/jrp.150
Chicago	KAZKAYASI İnci,TELLI GOKÇEN,UMA Serdar,BALCI Aylin Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. Journal of research in pharmacy (online) 26, no.3 (2022): 534 - 542. 10.29228/jrp.150
MLA	KAZKAYASI İnci,TELLI GOKÇEN,UMA Serdar,BALCI Aylin Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. Journal of research in pharmacy (online), vol.26, no.3, 2022, ss.534 - 542. 10.29228/jrp.150
AMA	KAZKAYASI İ,TELLI G,UMA S,BALCI A Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. Journal of research in pharmacy (online). 2022; 26(3): 534 - 542. 10.29228/jrp.150
Vancouver	KAZKAYASI İ,TELLI G,UMA S,BALCI A Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits. Journal of research in pharmacy (online). 2022; 26(3): 534 - 542. 10.29228/jrp.150
IEEE	KAZKAYASI İ,TELLI G,UMA S,BALCI A "Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits." Journal of research in pharmacy (online), 26, ss.534 - 542, 2022. 10.29228/jrp.150
ISNAD	KAZKAYASI, İnci vd. "Acute hyperglycemia causes oxidative stress which is prevented by vitamin E pretreatment in healthy rabbits". Journal of research in pharmacy (online) 26/3 (2022), 534-542. https://doi.org/10.29228/jrp.150