The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds

Büşra ERTAŞ, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye.)
Betül OKUYAN, (Marmara Üniversitesi, Eczacılık Fakültesi, Klinik Eczacılık Anabilim Dalı, İstanbul, Türkiye.)
Ali ŞEN, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, İstanbul, Türkiye.)
Feriha ERCAN, (Marmara Üniversitesii Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul, Türkiye)
Hüseyin ÖNEL, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye.)
Fatih GÖĞER, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Eskişehir, Türkiye)
Göksel ŞENER (Fenerbahçe Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
Journal of research in pharmacy (online)
0 0
Yıl: 2022 Cilt: 26 Sayı: 3 Sayfa Aralığı: 554 - 564 Metin Dili: İngilizce DOI: 10.29228/jrp.153 İndeks Tarihi: 08-06-2022

The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds

Öz:
The overall aim of the present research is to evaluate for the first time the curative effect of Cotinus coggygria leaves on burn injury in an experimental burn model along with its anti-inflammatory and antioxidant activity potential. Also, phenolic compounds of C. coggygria were characterised by LC-MS/MS. Wistar albino rats weighing 200- 250 g were exposed to 90°C bath for 10 s to induce burn injury, involving 30% of the total body surface area. In the treatment groups, 5% C. coggygria ethanol extract was applied topically as a cream immediately after the burn. Blood and skin tissue samples were taken after decapitation at the 4th and 48th hours following the burn procedure. Interleukin 1-β (IL-1β) and tumour necrosis factor (TNF-α) were determined in serum samples, and hydroxyproline, prostoglandin E2 (PGE2), and myeloperoxidase (MPO) activity and 8-hydroxy-2′-deoxy-guanosine (8-OHdG) levels were determined in skin tissue samples. Increased levels of serum cytokines were decreased with C. coggygria treatment in both periods. MPO activity, prostaglandine (PGE2), and 8-OhdG levels increased, while hydroxyproline levels decreased due to burn damage. On the other hand, these parameters were returned to its normal levels with C. coggygria treatment. In addition, the tissue histology of animals treated with C. coggygria showed a complete epithelialization with increased collagenation. As a result, C. coggygria may be an alternative treatment approach for burns-induced skin damage and wounds.
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APA ERTAS B, OKUYAN B, ŞEN A, Ercan F, ÖNEL H, GÖĞER F, ŞENER G (2022). The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. , 554 - 564. 10.29228/jrp.153
Chicago ERTAS BÜSRA,OKUYAN Betül,ŞEN ALİ,Ercan Feriha,ÖNEL Hüseyin,GÖĞER Fatih,ŞENER Göksel The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. (2022): 554 - 564. 10.29228/jrp.153
MLA ERTAS BÜSRA,OKUYAN Betül,ŞEN ALİ,Ercan Feriha,ÖNEL Hüseyin,GÖĞER Fatih,ŞENER Göksel The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. , 2022, ss.554 - 564. 10.29228/jrp.153
AMA ERTAS B,OKUYAN B,ŞEN A,Ercan F,ÖNEL H,GÖĞER F,ŞENER G The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. . 2022; 554 - 564. 10.29228/jrp.153
Vancouver ERTAS B,OKUYAN B,ŞEN A,Ercan F,ÖNEL H,GÖĞER F,ŞENER G The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. . 2022; 554 - 564. 10.29228/jrp.153
IEEE ERTAS B,OKUYAN B,ŞEN A,Ercan F,ÖNEL H,GÖĞER F,ŞENER G "The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds." , ss.554 - 564, 2022. 10.29228/jrp.153
ISNAD ERTAS, BÜSRA vd. "The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds". (2022), 554-564. https://doi.org/10.29228/jrp.153
APA ERTAS B, OKUYAN B, ŞEN A, Ercan F, ÖNEL H, GÖĞER F, ŞENER G (2022). The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. Journal of research in pharmacy (online), 26(3), 554 - 564. 10.29228/jrp.153
Chicago ERTAS BÜSRA,OKUYAN Betül,ŞEN ALİ,Ercan Feriha,ÖNEL Hüseyin,GÖĞER Fatih,ŞENER Göksel The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. Journal of research in pharmacy (online) 26, no.3 (2022): 554 - 564. 10.29228/jrp.153
MLA ERTAS BÜSRA,OKUYAN Betül,ŞEN ALİ,Ercan Feriha,ÖNEL Hüseyin,GÖĞER Fatih,ŞENER Göksel The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. Journal of research in pharmacy (online), vol.26, no.3, 2022, ss.554 - 564. 10.29228/jrp.153
AMA ERTAS B,OKUYAN B,ŞEN A,Ercan F,ÖNEL H,GÖĞER F,ŞENER G The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. Journal of research in pharmacy (online). 2022; 26(3): 554 - 564. 10.29228/jrp.153
Vancouver ERTAS B,OKUYAN B,ŞEN A,Ercan F,ÖNEL H,GÖĞER F,ŞENER G The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds. Journal of research in pharmacy (online). 2022; 26(3): 554 - 564. 10.29228/jrp.153
IEEE ERTAS B,OKUYAN B,ŞEN A,Ercan F,ÖNEL H,GÖĞER F,ŞENER G "The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds." Journal of research in pharmacy (online), 26, ss.554 - 564, 2022. 10.29228/jrp.153
ISNAD ERTAS, BÜSRA vd. "The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds". Journal of research in pharmacy (online) 26/3 (2022), 554-564. https://doi.org/10.29228/jrp.153
Sayfa Oluşturulma Tarihi
23-04-2024 22:58

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