TY  - JOUR
TI  - The effect of Cotinus coggygria L. ethanol extract in the
treatment of burn wounds
AB  - The overall aim of the present research is to evaluate for the first time the curative effect of Cotinus
coggygria leaves on burn injury in an experimental burn model along with its anti-inflammatory and antioxidant activity
potential. Also, phenolic compounds of C. coggygria were characterised by LC-MS/MS. Wistar albino rats weighing 200-
250 g were exposed to 90°C bath for 10 s to induce burn injury, involving 30% of the total body surface area. In the
treatment groups, 5% C. coggygria ethanol extract was applied topically as a cream immediately after the burn. Blood
and skin tissue samples were taken after decapitation at the 4th and 48th hours following the burn procedure. Interleukin
1-β (IL-1β) and tumour necrosis factor (TNF-α) were determined in serum samples, and hydroxyproline, prostoglandin
E2 (PGE2), and myeloperoxidase (MPO) activity and 8-hydroxy-2′-deoxy-guanosine (8-OHdG) levels were determined
in skin tissue samples. Increased levels of serum cytokines were decreased with C. coggygria treatment in both periods.
MPO activity, prostaglandine (PGE2), and 8-OhdG levels increased, while hydroxyproline levels decreased due to burn
damage. On the other hand, these parameters were returned to its normal levels with C. coggygria treatment. In addition,
the tissue histology of animals treated with C. coggygria showed a complete epithelialization with increased
collagenation. As a result, C. coggygria may be an alternative treatment approach for burns-induced skin damage and
wounds.
AU  - GÖĞER, Fatih
AU  - ŞENER, Göksel
AU  - ÖNEL, Hüseyin
AU  - OKUYAN, Betül
AU  - ŞEN, ALİ
AU  - Ercan, Feriha
AU  - ERTAS, BÜSRA
DO  - 10.29228/jrp.153
PY  - 2022
JO  - Journal of research in pharmacy (online)
VL  - 26
IS  - 3
SN  - 2630-6344
SP  - 554
EP  - 564
DB  - TRDizin
UR  - http://search/yayin/detay/515820
ER  -