Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts

Sara ZERROUKI, (Unité de recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie.)
Samia MEZHOUD, (Unité de recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie.)
Ayse SAHİN YAĞLIOĞLU, (Amasya Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Kimya ve Kimyasal Proses Teknolojisi Bölümü, 05186/ Amasya, Türkiye.)
Chawki BENSOUICI, (National Center of Biotechnology Research, Ali Mendjli,Constantine, Algeria)
Mehmet NURİ ATALAR, (Iğdır Üniversitesi, Fen-Edebiyat Fakültesi, Biyokimya Bölümü, Şehit Bülent Yurtseven Yerleşkesi, 76000, Iğdır, Türkiye.)
İbrahim DEMİRTAS, (Amasya Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Kimya ve Kimyasal Proses Teknolojisi Bölümü, 05186/ Amasya,Türkiye)
Souad AMEDDAH, (Laboratoire de Biologie et environnement, Faculté des sciences de la nature et de la vie, Université des Frères Mentouri Constantine 1, Constantine, Algeria.)
Ratiba MEKKIOU (Unité de recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Phys)
Journal of research in pharmacy (online)
14 0
Yıl: 2022 Cilt: 26 Sayı: 3 Sayfa Aralığı: 598 - 608 Metin Dili: İngilizce DOI: 10.29228/jrp.157 İndeks Tarihi: 08-06-2022

Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts

Öz:
Although notable medicinal value and biological activities such as antioxidant, antibacterial, antimicrobial and antifungal of Limoniastrum guyonianum have been reported, identification and quantification of phytoconstituents of CHCl3, EtOAC, and n-BuOH extracts from the aerial parts of the halophyte medicinal plant from Algerian Sahara was not well investigated for biological and anticancer activity in spite of their great interest. Therefore, the aim of this study was to investigate the antioxidant and anticancer activities of L. guyonianum. The phytoconstituents of CHCl3, EtOAC, and n-BuOH extracts were screened using HPLC-DAD. Total phenolic and flavonoid contents were quantified, antioxidant activity, using DPPH radical scavenging activity, ABTS+° decolorization, cupric reducing power, and anticancer activity against human cervical adenocarcinoma (HeLa) cell line were investigated and quantified. The results showed the presence of chlorogenic, gallic, syringic, p-coumaric, trans ferulic, o-coumaric acids, and quercetin in significant varying quantities. Chlorogenic acid was present in the greatest quantity (344.027–422.711mg/g of extract) as well as quercetin in CHCl3 extract. It is important to note the absence of caffeic acid and o-coumaric acid from EtOAc and CHCl3 extracts, respectively. The content of phenolic and flavonoid were higher in EtOAc extract (934±4,38mgGAE and 218.33±6.36mgQE/gof extract), respectively. EtOAc extract possesses a strong antioxidant effect in vitro, while the CHCl3 extract proved to be the most active againstHeLa cell lines (IC50= 50.369±0.020μg/ml). The findings in this studydemostrate the potential use of these compounds in medicine and importance of this species, which have largely been used in folk medicine for several diseases’ treatment.
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APA ZERROUKI S, MEZHOUD S, YAĞLIOĞLU A, bensouici c, ATALAR M, DEMİRTAS İ, AMEDDAH S, MEKKIOU R (2022). Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. , 598 - 608. 10.29228/jrp.157
Chicago ZERROUKI Sara,MEZHOUD Samia,YAĞLIOĞLU Ayse SAHİN,bensouici chawki,ATALAR Mehmet Nuri,DEMİRTAS İbrahim,AMEDDAH Souad,MEKKIOU Ratiba Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. (2022): 598 - 608. 10.29228/jrp.157
MLA ZERROUKI Sara,MEZHOUD Samia,YAĞLIOĞLU Ayse SAHİN,bensouici chawki,ATALAR Mehmet Nuri,DEMİRTAS İbrahim,AMEDDAH Souad,MEKKIOU Ratiba Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. , 2022, ss.598 - 608. 10.29228/jrp.157
AMA ZERROUKI S,MEZHOUD S,YAĞLIOĞLU A,bensouici c,ATALAR M,DEMİRTAS İ,AMEDDAH S,MEKKIOU R Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. . 2022; 598 - 608. 10.29228/jrp.157
Vancouver ZERROUKI S,MEZHOUD S,YAĞLIOĞLU A,bensouici c,ATALAR M,DEMİRTAS İ,AMEDDAH S,MEKKIOU R Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. . 2022; 598 - 608. 10.29228/jrp.157
IEEE ZERROUKI S,MEZHOUD S,YAĞLIOĞLU A,bensouici c,ATALAR M,DEMİRTAS İ,AMEDDAH S,MEKKIOU R "Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts." , ss.598 - 608, 2022. 10.29228/jrp.157
ISNAD ZERROUKI, Sara vd. "Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts". (2022), 598-608. https://doi.org/10.29228/jrp.157
APA ZERROUKI S, MEZHOUD S, YAĞLIOĞLU A, bensouici c, ATALAR M, DEMİRTAS İ, AMEDDAH S, MEKKIOU R (2022). Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. Journal of research in pharmacy (online), 26(3), 598 - 608. 10.29228/jrp.157
Chicago ZERROUKI Sara,MEZHOUD Samia,YAĞLIOĞLU Ayse SAHİN,bensouici chawki,ATALAR Mehmet Nuri,DEMİRTAS İbrahim,AMEDDAH Souad,MEKKIOU Ratiba Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. Journal of research in pharmacy (online) 26, no.3 (2022): 598 - 608. 10.29228/jrp.157
MLA ZERROUKI Sara,MEZHOUD Samia,YAĞLIOĞLU Ayse SAHİN,bensouici chawki,ATALAR Mehmet Nuri,DEMİRTAS İbrahim,AMEDDAH Souad,MEKKIOU Ratiba Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. Journal of research in pharmacy (online), vol.26, no.3, 2022, ss.598 - 608. 10.29228/jrp.157
AMA ZERROUKI S,MEZHOUD S,YAĞLIOĞLU A,bensouici c,ATALAR M,DEMİRTAS İ,AMEDDAH S,MEKKIOU R Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. Journal of research in pharmacy (online). 2022; 26(3): 598 - 608. 10.29228/jrp.157
Vancouver ZERROUKI S,MEZHOUD S,YAĞLIOĞLU A,bensouici c,ATALAR M,DEMİRTAS İ,AMEDDAH S,MEKKIOU R Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts. Journal of research in pharmacy (online). 2022; 26(3): 598 - 608. 10.29228/jrp.157
IEEE ZERROUKI S,MEZHOUD S,YAĞLIOĞLU A,bensouici c,ATALAR M,DEMİRTAS İ,AMEDDAH S,MEKKIOU R "Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts." Journal of research in pharmacy (online), 26, ss.598 - 608, 2022. 10.29228/jrp.157
ISNAD ZERROUKI, Sara vd. "Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts". Journal of research in pharmacy (online) 26/3 (2022), 598-608. https://doi.org/10.29228/jrp.157
Sayfa Oluşturulma Tarihi
23-04-2024 22:58

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