TY  - JOUR
TI  - Synthesis, characterization and antimicrobial evaluation of new
2-(2-thienylcarbonyl)hydrazono-3-alkyl/aryl-4-thiazolidinone and
2-aryl-3-(2-thienylcarbonyl)amino-4-thiazolidinone derivatives
AB  - A series of novel 2-(2-thienylcarbonyl)hydrazono-3-alkyl/aryl-4-thiazolidinone (2a-f), 2-(2-thienyl)-5-[(4-
bromophenyl)amino]-1,3,4-oxadiazole (3), 2-aryl-3-(2-thienylcarbonyl)amino-4-thiazolidinone (5a-h) and 2-aryl-3-(2-
thienylcarbonyl)amino-5-methyl-4-thiazolidinone (6a-h) were designed and synthesized. The structural elucidations of
the novel compounds were performed by IR, 1H-NMR, mass and elemental analysis. The compounds were evaluated
for their antimycobacterial and antifungal activities. According to the biological activity studies activities of the
compounds, 2f (MIC: >12.5 μg/ml, 76% inhibition), 3 (MIC: >12.5 μg/ml, 43% inhibition), and 5c (MIC: >12.5 μg/ml,
38% inhibition), displayed antimycobacterial activity. 2b (MIC: 25 μg/ml) displayed antifungal activity against T.
rubrum. Besides, x-ray crystallography studies were performed to illuminate the structure of 2e. Consequently, the
obtained results relvealed that 2f, 3 and 5c present a leading structure for future drug development due to its
straightforward synthesis and relevant bioactivity.
AU  - ÖZBEY, Süheyla
AU  - ULUSOY-GÜZELDEMİRCİ, Nuray
AU  - Satana, Dilek
AU  - DİNCEL, Efe Doğukan
DO  - 10.29228/jrp.161
PY  - 2022
JO  - Journal of research in pharmacy (online)
VL  - 26
IS  - 3
SN  - 2630-6344
SP  - 641
EP  - 654
DB  - TRDizin
UR  - http://search/yayin/detay/515830
ER  -