TY  - JOUR
TI  - Protective Role of Diospyros lotus L. in Cisplatin-
Induced Cardiotoxicity: Cardiac Damage and
Oxidative Stress in Rats
AB  - Objectives: Cisplatin is a powerful chemotherapeutic drug that is used to treatment a wide variety of cancers. Despite clinical data demonstrating
the cardiotoxic effect of cisplatin, few studies have been carried to improve the cardiotoxicity of cisplatin. In cisplatin-induced toxicity, oxidative
stress plays a critical role. This study determined the effect of Diospyros lotus L. fruit (DL), a powerful antioxidant plant, on heart damage caused by
cisplatin through histological examination and oxidative stress parameters.
Materials and Methods: Twenty eight male rats were randomly divided into four groups. An isotonic solution was given to the control group. A
single dose of 7 mg/kg cisplatin was administered intraperitoneally to the cisplatin group. 1.000 mg/kg DL was given by gavage for 10 days to the
DL group. Cisplatin and DL were administered together in the same doses to the treatment group. Thiobarbituric acid reactive substances (TBARS)
levels, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, and total glutathione (GSH) level were measured in the
heart tissue of the experimental rats. Histological examination was also performed to determine any damage to the hearts of the experimental rats.
Results: While TBARS levels in the cisplatin group increased significantly, SOD, CAT, GPx activities, and total GSH level decreased significantly.
TBARS levels decreased significantly and SOD, CAT, GPx activities and GSH levels increased with DL treatment. According to the histological
examination, histopathological differences were observed in the cisplatin group. Histopathological findings were either absent or decreased in the
DL-treated group.
Conclusion: Results of the study showed that DL therapy reduced oxidative stress and histological changes caused by cisplatin. DL could be a
potential candidate for reducing cardiac damage caused by cisplatin.
AU  - başak türkmen, neşe
AU  - gül, cemile ceren
AU  - SARAL, OZLEM
AU  - AŞKIN ÖZEK, DİLAN
AU  - Ciftci, Osman
AU  - ÇETİN, Aslı
DO  - 10.4274/tjps.galenos.2021.84555
PY  - 2022
JO  - Turkish Journal of Pharmaceutical Sciences
VL  - 19
IS  - 2
SN  - 1304-530X
SP  - 132
EP  - 137
DB  - TRDizin
UR  - http://search/yayin/detay/515899
ER  -