TY  - JOUR
TI  - Efficacy of the Novel Degludec/Aspart Insulin Co-formulation in
Children and Adolescents with Type 1 Diabetes:
A Real-life Experience with One Year of IDegAsp Therapy in
Poorly Controlled and Non-compliant Patients
AB  - Objective: To evaluate the efficacy of degludec/aspart (IDegAsp) insulin co-formulation in children and adolescents with poorly controlled
type 1 diabetes (T1DM).
Methods: Patients with poorly controlled T1DM on basal-bolus insulin regimes and having compliance problems related to insulin
injections were switched to IDegAsp and were included. Data on hemoglobin A1c (HbA1c) levels, hypoglycemic episodes, frequency of
diabetic ketoacidosis (DKA) and insulin doses were recorded at baseline and after one year of IDegAsp treatment.
Results: Fifty patients (22 girls; 44%) were started on IDegAsp. The mean±standard deviation (range) age and duration of diabetes
were 12.9±3.4 (4-18) and 5.2±3.1 (1.0-13.7) years, respectively. At the end of one year, 38 patients were still on IDegAsp, whereas
12 patients had opted to resume their original treatments. In those who continued on IDegAsp, HbA1c levels did not change, but
the number of self-reported mild-moderate hypoglycemic episodes decreased significantly (p<0.05). In the year before switching to
IDegAsp, 11 DKA attacks in 9 patients were observed, whereas this decreased to 4 DKA attacks in 4 patients after one year of IDegAsp
therapy (p=0.06).
Conclusion: IDegAsp regimen may improve clinical management in poorly controlled basal-bolus insulin regimen T1DM patients who
have frequent hypoglycemia and DKA attacks, as well as in those with poor compliance with multiple injections. Although a simplified
basal-bolus IDegAsp regimen is an attractive option for patients with T1DM, some may not adapt to this treatment due to the fixed IAsp
dose of IDegAsp.
AU  - Yavaş Abalı, Zehra
AU  - GURAN, TULAY
AU  - Bereket, Abdullah
AU  - Eltan, Mehmet
AU  - Kirkgoz, Tarik
AU  - Helvacıoğlu, Didem
AU  - MENEVŞE, Tuba Seven
AU  - Gurpinar Tosun, Busra
AU  - Demircioglu, Serap
AU  - KAYGUSUZ, Sare Betül
DO  - 10.4274/jcrpe.galenos.2021.2021.0113
PY  - 2022
JO  - Journal of Clinical Research in Pediatric Endocrinology
VL  - 14
IS  - 1
SN  - 1308-5727
SP  - 10
EP  - 16
DB  - TRDizin
UR  - http://search/yayin/detay/515945
ER  -