TY  - JOUR
TI  - Prophylactic Use of Levosimendan in High-Risk Coronary 
Artery Disease: Retrospective Clinical Research
AB  - Objective: To investigate the perioperative and postoperative effects of preoperative levosimendan use in coronary artery patients with low ejection fraction (EF) (<40%). Material and Methods:
A total of 6,571 coronary bypass patients who were treated at Kartal 
Koşuyolu High Specialization Training and Research Hospital between 
2016 and 2019 were scanned, and 132 patients with preoperative EF 
below 40% were retrospectively analyzed. The patients were divided 
into 2 groups as those who received preoperative levosimendan (Group 
1: 90 patients) and the control group, who did not receive it at all 
(Group 2: 42 patients). All of the patients included in the study were onpump coronary bypass patients and excluded off-pump bypass, emergency bypass, and other concomitant procedures. Results: In terms of 
EF values, improvements over time were significantly different in favor 
of Group 1 (p<0.043). The duration of the intensive care unit stay in 
Group 1 was longer (p<0.047). The changes in patients in terms of postoperative venous oxygen saturation over time were found to be statistically positive in favor of Group 1 (p<0.042). Mortality was observed 
in 5 patients in the postoperative early period (first 30 days), all of 
whom were from Group 1. However, no statistical difference was observed. Conclusion: Preoperative use of levosimendan in coronary 
artery patients with low EF improved some hemodynamic parameters; 
however, it did not make a significant hemodynamic and clinical contribution to surgery success in high-risk patients.
AU  - Öztürk, Fatih
AU  - HANCER, Hakan
AU  - Yanartas, Mehmed
AU  - Zengin, Ahmet
AU  - YİĞİT, FATİH
AU  - FEDAKAR, ALİ
AU  - Çiçekçioğlu, Ferit
AU  - Başar, Veysel
DO  - 10.5336/cardiosci.2021-83584
PY  - 2022
JO  - Türkiye Klinikleri Cardiovascular Sciences
VL  - 34
IS  - 1
SN  - 1306-7656
SP  - 1
EP  - 6
DB  - TRDizin
UR  - http://search/yayin/detay/516215
ER  -