TY  - JOUR
TI  - The effects of sildenafil and N-acetylcysteine
the zone of stasis in burns
AB  - BACKGROUND: In burn wound healing, zones of burn, namely zone of hyperemia, the zone of stasis, and zone of coagulation,
have crucial importance. These zones have been identified based on the pathophysiology of the burn, and treatment of burn has been
improved. The zone of necrosis is treated by excision and repair through grafting. Zone of stasis fully recovers in 24–48 h if the burn
treatment is managed well. Otherwise, it may convert to a zone of coagulation. Hyperemia zone is a zone that recovers itself. Recovery of the zone of stasis is very critical in burn treatment. Active oxygen radicals produced due to the hypermetabolism due to burn
wounds are known to speed to the process of the zone of stasis converting into the zone of coagulation. The present experimental
study aims to evaluate the effects of sildenafil and N-acetylcysteine on the zone of stasis and to establish whether they had any contribution to wound healing in burns.
METHODS: In the present study, 32 four months old female Wistar Albino rats with 200±20 gr body weights were used. The rats
were divided into four groups as the sham group (Group 1), the intraperitoneal group (Group 2), Sildenafil group (Group 3, intraperitoneal 10 mg/kg for 10 days), N-acetylcysteine (Group 4, intraperitoneal 100 mg/kg for 10 days). Tissue samples were collected for serum
and cytopathology studies of the Malondialdehyde level, glutathione peroxidase, superoxide dismutase, and catalyze enzyme activity.
All the rats were sacrificed on the 10th day of the tests edema, hyperemia, epithelial degeneration, necrosis, inflammatory infiltration
and fibrosis measurements were made.
RESULTS: When compared with the controls, both of the treatment groups had lower tissue damage scores. MDA level was lower
in Group 3 and 4 compared to Group 2 and lower in Group 3 compared to Group 4. SOD, catalase and GPH-Px levels were higher in
Group 3 and Group 4 compared to Group 2 and higher in Group 3 compared to Group 4.
CONCLUSION: The results of our study conducted on an experimental burn model created by rats support that Sildenafil and
N-acetylcysteine have positive effects, such as decreasing oxidative stress level and increasing wound healing in burns. Further experimental studies are required on this subject.
AU  - bostancı, meriç emre
AU  - hepokur, ceylan
AU  - Kisli, Erol
DO  - 10.14744/tjtes.2020.25679
PY  - 2021
JO  - Ulusal Travma ve Acil Cerrahi Dergisi
VL  - 27
IS  - 1
SN  - 1306-696X
SP  - 9
EP  - 16
DB  - TRDizin
UR  - http://search/yayin/detay/516844
ER  -