TY  - JOUR
TI  - Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress
and their relationship with vitamin D status
AB  - Background/aim: Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investigate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an attack-free period.
Materials and methods: In the cross-sectional study, ninety children with FMF in the attack-free period and 30 healthy children were included. Patients were grouped according to their vitamin D status (< 20, 20–29, and 30–100 ng/mL). The groups were compared in terms of pentraxin 3 (PTX-3), total oxidant status (TOS), and total antioxidant status (TAS). Multivariable linear regression analysis was performed to identify factors associated with vitamin D status.
Results: PTX-3 levels were significantly higher in patients with vitamin D insufficiency (20-29 ng/mL) than in the group with vitamin
D sufficient (30–100 ng/mL). Patients with vitamin D deficiency (< 20 ng/mL) had higher TOS. A strong negative correlation was observed between vitamin D levels and TOS (p = 0.003). Subclinical inflammation (PTX-3 ≥ 0.640) and high TOS levels were negatively associated with vitamin D levels.
Conclusion: Subclinical inflammation and oxidative stress were negatively associated with vitamin D levels in patients with FMF during an attack-free period. Sufficient vitamin D levels are important in fighting subclinical inflammation and oxidative stress in children with FMF.
AU  - Muhtaroğlu, Sabahattin
AU  - Pac Kisaarslan, Aysenur
AU  - Barlak Keti, Didem
AU  - Alesh, MHD Boshr
AU  - TAŞKIN, Sema Nur
DO  - 10.3906/sag-2103-235
PY  - 2022
JO  - Turkish Journal of Medical Sciences
VL  - 52
IS  - 1
SN  - 1300-0144
SP  - 67
EP  - 75
DB  - TRDizin
UR  - http://search/yayin/detay/516851
ER  -