The Relationship between Early Neurological Deterioration, Poor
Clinical Outcome, and Venous Collateral Score in Cerebral Venous
Sinus Thrombosis

Hakyemez, Bahattin; Bakar, Mustafa; DİNÇ, Yasemin; ÖZPAR, Rıfat

doi:10.4103/nsn.nsn_223_20

The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis

Yasemin DİNÇ, (Uludağ Üniversitesi, Tıp Fakültesi, Nöroloji Bölümü, Bursa, Türkiye)

Rıfat ÖZPAR, (Uludağ Üniversitesi, Tıp Fakültesi, Radyoloji Bölümü, Bursa, Türkiye)

Bahattin HAKYEMEZ, (Uludağ Üniversitesi, Tıp Fakültesi, Radyoloji Bölümü, Bursa, Türkiye)

Mustafa BAKAR (Uludağ Üniversitesi, Tıp Fakültesi, Nöroloji Bölümü, Bursa, Türkiye)

Neurological sciences and neurophysiology (Online)

4 1

Yıl: 2021 Cilt: 38 Sayı: 3 Sayfa Aralığı: 158 - 165 Metin Dili: İngilizce DOI: 10.4103/nsn.nsn_223_20 İndeks Tarihi: 11-06-2022

The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis

Öz:

Background and Purpose: Cerebral venous sinus thrombosis (CVST) is one of the rare causes of cerebrovascular disease and has an extremely heterogeneous prognosis. The aim of this study was to investigate the potential relationship between early neurological deterioration, poor clinical outcome in CVST and the venous collateral score. Materials and Methods: A total of 121 patients diagnosed with CVST between 2010 and 2020 were retrospectively included. The demographic, clinical, and radiological findings related to venous sinus thrombosis and early neurological deterioration were investigated in relation to the clinical outcome. Results: The factors associated with early neurological deterioration were superior sagittal sinus thrombosis (P < 0.001), sinus rectus thrombosis (P = 0.031), parenchymal lesions (P < 0.001), and venous collateral score (P < 0.001). The factors associated with poor clinical outcome were superior sagittal sinus thrombosis (P < 0.001), cortical vein thrombosis (P < 0.001), venous collateral score (P < 0.001), and initial clinical symptoms. Binary logistic regression analyses revealed poor clinical outcome as a significant variable, with a venous collateral scale of 0 or 1 as a risk factor for a poor outcome (significance of the modelP < 0.001). Conclusion: Early neurologic deterioration and poor clinical outcome may occur due to poor collateralization in CVST. Identifying the subgroup of CVST patients at risk of clinical deterioration is therefore important. This study highlights the clinical importance of venous collaterals; however, larger prospective multicenter studies are required to confirm the relationship with venous collaterals in patients with CVST.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Bousser MG, Crassard I. Cerebral venous thrombosis, pregnancy and oral contraceptives. Thromb Res 2012;130 Suppl 1:S19‑22.
2. Stam J. Thrombosis of the cerebral veins and sinuses. N Engl J Med 2005;352:1791‑8.
3. Bousser MG, Ferro JM. Cerebral venous thrombosis: An update. Lancet Neurol 2007;6:162‑70.
4. Coutinho JM, Zuurbier SM, Aramideh M, Stam J. The incidence of cerebral venous thrombosis: A cross‑sectional study. Stroke 2012;43:3375‑7.
5. Dlamini N, Billinghurst L, Kirkham FJ. Cerebral venous sinus (sinovenous) thrombosis in children. Neurosurg Clin N Am 2010;21:511‑27.
6. Corvol JC, Oppenheim C, Manaï R, Logak M, Dormont D, Samson Y, et al. Diffusion‑weighted magnetic resonance imaging in a case of cerebral venous thrombosis. Stroke 1998;29:2649‑52.
7. Yoshikawa T, Abe O, Tsuchiya K, Okubo T, Tobe K, Masumoto T, et al. Diffusion‑weighted magnetic resonance imaging of dural sinus thrombosis. Neuroradiology 2002;44:481‑8.
8. Guenther G, Arauz A. Cerebral venous thrombosis: A diagnostic and treatment update. Neurologia 2011;26:488‑98.
9. de Bruijn SF, Stam J. Randomized, placebo‑controlled trial of anticoagulant treatment with low‑molecular‑weight heparin for cerebral sinus thrombosis. Stroke 1999;30:484‑8.
10. Coutinho JM, Stam J. How to treat cerebral venous and sinus thrombosis. J Thromb Haemost 2010;8:877‑83.
11. Coutinho J, de Bruijn SF, Deveber G, Stam J. Anticoagulation for cerebral venous sinus thrombosis. Cochrane Database Syst Rev 2011;2011:CD002005.
12. Saposnik G, Barinagarrementeria F, Brown RD Jr., Bushnell CD, Cucchiara B, Cushman M, et al. Diagnosis and management of cerebral venous thrombosis: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011;42:1158‑92.
13. Qureshi AI. A classification scheme for assessing recanalization and collateral formation following cerebral venous thrombosis. J Vasc Interv Neurol 2010;3:1‑2.
14. Barboza MA, Mejías C, Colin‑Luna J, Quiroz‑Compean A, Arauz A. Intracranial venous collaterals in cerebral venous thrombosis: Clinical and imaging impact. J Neurol Neurosurg Psychiatry 2015;86:1314‑8.
15. Sheth SA, Trieu H, Liebeskind DS, Saver JL, Szeder V, Jahan R, et al. Venous collateral drainage patterns predict clinical worsening in dural venous sinus thrombosis. J Neurointerv Surg 2018;10:171‑5.
16. Cuadrado‑Godia E. Early neurological deterioration, easy methods to detect it. Indian J Med Res 2015;141:266‑8.
17. Ruiz‑Sandoval JL, Chiquete E, Bañuelos‑Becerra LJ, Torres‑Anguiano C, González‑Padilla C, Arauz A,et al. Cerebral venous thrombosis in a Mexican multicenter registry of acute cerebrovascular disease: The RENAMEVASC study. J Stroke Cerebrovasc Dis 2012;21:395‑400.
18. Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F. Prognosis of cerebral vein and dural sinus thrombosis: Results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004;35:664‑70.
19. Dentali F, Gianni M, Crowther MA, Ageno W. Natural history of cerebral vein thrombosis: A systematic review. Blood 2006;108:1129‑34.
20. Daif A, Awada A, al‑Rajeh S, Abduljabbar M, al Tahan AR, Obeid T, et al. Cerebral venous thrombosis in adults. A study of 40 cases from Saudi Arabia. Stroke 1995;26:1193‑5.
21. Ferro JM, Canhão P, Bousser MG, Stam J, Barinagarrementeria F; ISCVT Investigators. Cerebral vein and dural sinus thrombosis in elderly patients. Stroke 2005;36:1927‑32.
22. Khealani BA, Wasay M, Saadah M, Sultana E, Mustafa S, Khan FS, et al. Cerebral venous thrombosis: A descriptive multicenter study of patients in Pakistan and Middle East. Stroke 2008;39:2707‑11.
23. Koopman K, Uyttenboogaart M, Vroomen PC, van der Meer J, De Keyser J, Luijckx GJ. Long‑term sequelae after cerebral venous thrombosis in functionally independent patients. J Stroke Cerebrovasc Dis 2009;18:198‑202.
24. Canhão P, Ferro JM, Lindgren AG, Bousser MG, Stam J, Barinagarrementeria F, et al. Causes and predictors of death in cerebral venous thrombosis. Stroke 2005;36:1720‑5.
25. Yii IY, Mitchell PJ, Dowling RJ, Yan B. Imaging predictors of clinical deterioration in cerebral venous thrombosis. J Clin Neurosci 2012;19:1525‑9.
26. Krajíčková D, Klzo L, Krajina A, Vyšata O, Herzig R, Vališ M. Cerebral venous sinus thrombosis: Clinical characteristics and factors influencing clinical outcome. Clin Appl Thromb Hemost 2016;22:665‑72.
27. de Bruijn SF, de Haan RJ, Stam J. Clinical features and prognostic factors of cerebral venous sinus thrombosis in a prospective series of 59 patients. For The Cerebral Venous Sinus Thrombosis Study Group. J Neurol Neurosurg Psychiatry 2001;70:105‑8.
28. Kenet G, Kirkham F, Niederstadt T, Heinecke A, Saunders D, Stoll M, et al. Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis: A multicentre cohort study. Lancet Neurol 2007;6:595‑603.

APA	DİNÇ Y, ÖZPAR R, Hakyemez B, Bakar M (2021). The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. , 158 - 165. 10.4103/nsn.nsn_223_20
Chicago	DİNÇ Yasemin,ÖZPAR Rıfat,Hakyemez Bahattin,Bakar Mustafa The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. (2021): 158 - 165. 10.4103/nsn.nsn_223_20
MLA	DİNÇ Yasemin,ÖZPAR Rıfat,Hakyemez Bahattin,Bakar Mustafa The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. , 2021, ss.158 - 165. 10.4103/nsn.nsn_223_20
AMA	DİNÇ Y,ÖZPAR R,Hakyemez B,Bakar M The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. . 2021; 158 - 165. 10.4103/nsn.nsn_223_20
Vancouver	DİNÇ Y,ÖZPAR R,Hakyemez B,Bakar M The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. . 2021; 158 - 165. 10.4103/nsn.nsn_223_20
IEEE	DİNÇ Y,ÖZPAR R,Hakyemez B,Bakar M "The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis." , ss.158 - 165, 2021. 10.4103/nsn.nsn_223_20
ISNAD	DİNÇ, Yasemin vd. "The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis". (2021), 158-165. https://doi.org/10.4103/nsn.nsn_223_20

APA	DİNÇ Y, ÖZPAR R, Hakyemez B, Bakar M (2021). The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. Neurological sciences and neurophysiology (Online), 38(3), 158 - 165. 10.4103/nsn.nsn_223_20
Chicago	DİNÇ Yasemin,ÖZPAR Rıfat,Hakyemez Bahattin,Bakar Mustafa The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. Neurological sciences and neurophysiology (Online) 38, no.3 (2021): 158 - 165. 10.4103/nsn.nsn_223_20
MLA	DİNÇ Yasemin,ÖZPAR Rıfat,Hakyemez Bahattin,Bakar Mustafa The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. Neurological sciences and neurophysiology (Online), vol.38, no.3, 2021, ss.158 - 165. 10.4103/nsn.nsn_223_20
AMA	DİNÇ Y,ÖZPAR R,Hakyemez B,Bakar M The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. Neurological sciences and neurophysiology (Online). 2021; 38(3): 158 - 165. 10.4103/nsn.nsn_223_20
Vancouver	DİNÇ Y,ÖZPAR R,Hakyemez B,Bakar M The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis. Neurological sciences and neurophysiology (Online). 2021; 38(3): 158 - 165. 10.4103/nsn.nsn_223_20
IEEE	DİNÇ Y,ÖZPAR R,Hakyemez B,Bakar M "The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis." Neurological sciences and neurophysiology (Online), 38, ss.158 - 165, 2021. 10.4103/nsn.nsn_223_20
ISNAD	DİNÇ, Yasemin vd. "The Relationship between Early Neurological Deterioration, Poor Clinical Outcome, and Venous Collateral Score in Cerebral Venous Sinus Thrombosis". Neurological sciences and neurophysiology (Online) 38/3 (2021), 158-165. https://doi.org/10.4103/nsn.nsn_223_20