Antiviral MicroRNA Expression Signatures are Altered in Subacute
Sclerosing Panencephalitis

YİŞ, Uluç; TOPÇU, Yasemin; ALLMER, Jens; Bayram, Erhan; TÜFEKÇİ, Kemal Uğur; HIZ, Semra; GENÇ, Şermin; ÇARMAN, Kürşat Bora

doi:10.4103/nsn.nsn_57_21

Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis

Kemal Uğur TÜFEKÇİ, (İzmir Demokrasi Üniversitesi, Sağlık Hizmetleri Meslek Yüksek Okulu, İzmir, Türkiye)

Jens ALLMER, (İzmir Teknoloji Enstitüsü, Biyoloji ve Genetik Moleküler Bölümü, İzmir, Türkiye)

Kürşat Bora ÇARMAN, (Gaziantep Çocuk Hastanesi, Çocuk Nöroloji Anabilim Dalı, Gaziantep, Türkiye)

Erhan BAYRAM, (Dokuz Eylül Üniversitesi, Tıp Okulu, Pediatri Anabilim Dalı, Çocuk Nörolojisi, İzmir, Türkiye)

Yasemin TOPÇU, (Dokuz Eylül Üniversitesi, Tıp Okulu, Pediatri Anabilim Dalı, Çocuk Nörolojisi, İzmir, Türkiye)

Semra HIZ, (Dokuz Eylül Üniversitesi, Tıp Okulu, Pediatri Anabilim Dalı, Çocuk Nörolojisi, İzmir, Türkiye)

Şermin GENÇ, (Dokuz Eylül Üniversitesi, Sağlık Bilimleri, Nörobilim Enstitüsü, İzmir, Türkiye)

Uluç YİŞ (Dokuz Eylül Üniversitesi, Tıp Okulu, Pediatri Anabilim Dalı, Çocuk Nörolojisi, İzmir, Türkiye)

Neurological sciences and neurophysiology (Online)

9 0

Yıl: 2021 Cilt: 38 Sayı: 3 Sayfa Aralığı: 166 - 172 Metin Dili: İngilizce DOI: 10.4103/nsn.nsn_57_21 İndeks Tarihi: 11-06-2022

Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis

Öz:

Background: Subacute sclerosing panencephalitis (SSPE) is a chronic, progressive disease caused by a persistent infection of the measles virus. Despite extensive efforts, the exact neurodegeneration mechanism in SSPE remains unknown. MicroRNAs (miRNAs) have emerged as an essential part of cellular antiviral defense mechanisms and can be modulated by antiviral cytokines Such as interferon‐beta (IFN‐β). Aims and Objectives: In this study, we aimed to elucidate the role of antiviral miRNAs in the pathogenesis of SSPE and analyze the interaction between host antiviral miRNAs and virus genes. Materials and Methods: Thirty‐seven patients who were followed with SSPE and age‐matched healthy children were included in the study. Peripheral blood mononuclear cell levels of miR‐196b, miR‐296, miR‐431, and miR‐448 were analyzed using quantitative polymerase chain reaction. Target predictions and pathway constructions of deregulated miRNAs were assessed. Results: Here, we showed that IFN‐β‐ modulated miR‐196b, miR‐296, and miR‐431 were significantly upregulated in patients with SSPE compared with healthy controls. Besides, sequence complementarity analysis showed that miR‐296 and miR‐196b predicted binding regions in measles virus genomic RNA. Conclusion: Our findings suggest that antiviral miRNAs are upregulated in patients with SSPE, which could be a part of the host antiviral defense mechanism.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TÜFEKÇİ K, ALLMER J, ÇARMAN K, Bayram E, TOPÇU Y, HIZ S, GENÇ Ş, YİŞ U (2021). Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. , 166 - 172. 10.4103/nsn.nsn_57_21
Chicago	TÜFEKÇİ Kemal Uğur,ALLMER Jens,ÇARMAN Kürşat Bora,Bayram Erhan,TOPÇU Yasemin,HIZ Semra,GENÇ Şermin,YİŞ Uluç Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. (2021): 166 - 172. 10.4103/nsn.nsn_57_21
MLA	TÜFEKÇİ Kemal Uğur,ALLMER Jens,ÇARMAN Kürşat Bora,Bayram Erhan,TOPÇU Yasemin,HIZ Semra,GENÇ Şermin,YİŞ Uluç Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. , 2021, ss.166 - 172. 10.4103/nsn.nsn_57_21
AMA	TÜFEKÇİ K,ALLMER J,ÇARMAN K,Bayram E,TOPÇU Y,HIZ S,GENÇ Ş,YİŞ U Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. . 2021; 166 - 172. 10.4103/nsn.nsn_57_21
Vancouver	TÜFEKÇİ K,ALLMER J,ÇARMAN K,Bayram E,TOPÇU Y,HIZ S,GENÇ Ş,YİŞ U Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. . 2021; 166 - 172. 10.4103/nsn.nsn_57_21
IEEE	TÜFEKÇİ K,ALLMER J,ÇARMAN K,Bayram E,TOPÇU Y,HIZ S,GENÇ Ş,YİŞ U "Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis." , ss.166 - 172, 2021. 10.4103/nsn.nsn_57_21
ISNAD	TÜFEKÇİ, Kemal Uğur vd. "Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis". (2021), 166-172. https://doi.org/10.4103/nsn.nsn_57_21

APA	TÜFEKÇİ K, ALLMER J, ÇARMAN K, Bayram E, TOPÇU Y, HIZ S, GENÇ Ş, YİŞ U (2021). Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. Neurological sciences and neurophysiology (Online), 38(3), 166 - 172. 10.4103/nsn.nsn_57_21
Chicago	TÜFEKÇİ Kemal Uğur,ALLMER Jens,ÇARMAN Kürşat Bora,Bayram Erhan,TOPÇU Yasemin,HIZ Semra,GENÇ Şermin,YİŞ Uluç Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. Neurological sciences and neurophysiology (Online) 38, no.3 (2021): 166 - 172. 10.4103/nsn.nsn_57_21
MLA	TÜFEKÇİ Kemal Uğur,ALLMER Jens,ÇARMAN Kürşat Bora,Bayram Erhan,TOPÇU Yasemin,HIZ Semra,GENÇ Şermin,YİŞ Uluç Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. Neurological sciences and neurophysiology (Online), vol.38, no.3, 2021, ss.166 - 172. 10.4103/nsn.nsn_57_21
AMA	TÜFEKÇİ K,ALLMER J,ÇARMAN K,Bayram E,TOPÇU Y,HIZ S,GENÇ Ş,YİŞ U Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. Neurological sciences and neurophysiology (Online). 2021; 38(3): 166 - 172. 10.4103/nsn.nsn_57_21
Vancouver	TÜFEKÇİ K,ALLMER J,ÇARMAN K,Bayram E,TOPÇU Y,HIZ S,GENÇ Ş,YİŞ U Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. Neurological sciences and neurophysiology (Online). 2021; 38(3): 166 - 172. 10.4103/nsn.nsn_57_21
IEEE	TÜFEKÇİ K,ALLMER J,ÇARMAN K,Bayram E,TOPÇU Y,HIZ S,GENÇ Ş,YİŞ U "Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis." Neurological sciences and neurophysiology (Online), 38, ss.166 - 172, 2021. 10.4103/nsn.nsn_57_21
ISNAD	TÜFEKÇİ, Kemal Uğur vd. "Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis". Neurological sciences and neurophysiology (Online) 38/3 (2021), 166-172. https://doi.org/10.4103/nsn.nsn_57_21