TY  - JOUR
TI  - Antiviral MicroRNA Expression Signatures are Altered in Subacute
Sclerosing Panencephalitis
AB  - Background: Subacute sclerosing panencephalitis (SSPE) is a chronic, progressive disease
caused by a persistent infection of the measles virus. Despite extensive efforts, the exact
neurodegeneration mechanism in SSPE remains unknown. MicroRNAs (miRNAs) have emerged
as an essential part of cellular antiviral defense mechanisms and can be modulated by antiviral
cytokines Such as interferon‐beta (IFN‐β). Aims and Objectives: In this study, we aimed to
elucidate the role of antiviral miRNAs in the pathogenesis of SSPE and analyze the interaction
between host antiviral miRNAs and virus genes. Materials and Methods: Thirty‐seven patients
who were followed with SSPE and age‐matched healthy children were included in the study.
Peripheral blood mononuclear cell levels of miR‐196b, miR‐296, miR‐431, and miR‐448
were analyzed using quantitative polymerase chain reaction. Target predictions and pathway
constructions of deregulated miRNAs were assessed. Results: Here, we showed that IFN‐β‐
modulated miR‐196b, miR‐296, and miR‐431 were significantly upregulated in patients with
SSPE compared with healthy controls. Besides, sequence complementarity analysis showed that
miR‐296 and miR‐196b predicted binding regions in measles virus genomic RNA. Conclusion:
Our findings suggest that antiviral miRNAs are upregulated in patients with SSPE, which could
be a part of the host antiviral defense mechanism.
AU  - YİŞ, Uluç
AU  - TOPÇU, Yasemin
AU  - ALLMER, Jens
AU  - Bayram, Erhan
AU  - TÜFEKÇİ, Kemal Uğur
AU  - HIZ, Semra
AU  - GENÇ, Şermin
AU  - ÇARMAN, Kürşat Bora
DO  - 10.4103/nsn.nsn_57_21
PY  - 2021
JO  - Neurological sciences and neurophysiology (Online)
VL  - 38
IS  - 3
SN  - 2636-865X
SP  - 166
EP  - 172
DB  - TRDizin
UR  - http://search/yayin/detay/516999
ER  -