Impaction of the polylactic membrane or hydrofiber
with silver dressings on the interleukin-6, tumor necrosis
factor-α, transforming growth factor-b3
 levels in the blood
and tissues of pediatric patients with burns

Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns

Öz:

BACKGROUND: We aimed to evaluate the effects of two different burn dressings, hydrofiber with a silver (HFAg) and polylactic membrane (PLM), on altering the levels of important biomarkers Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α), Transforming growth factor-β3 (TGF-β3 ) in blood and burnt tissue in children with second-degree burns. METHODS: Children between the ages of one to 16 years, with 25–50% second-degree partial-thickness burns of the total body surface area were included in this study. Patients in the PLM group were dressed with PLM in a typical way according to the manual. The HFAg group was dressed with HFAg and a sterile cover. During and at the end of the 21-day treatment, blood and skin tissue samples were taken from the two burn and control groups. IL-6, TNF-α, and TGF-β β3 levels were evaluated in blood and tissue samples from all groups, and the results were analyzed statistically. RESULTS: In the PLM group, IL-6 and TNF-α levels decreased early days in both serum and tissue samples to reach normal ranges compared with the HFAg group. In the PLM group, TGF-β3 levels were elevated than in other groups for two weeks. CONCLUSION: In this study, we found that PLM controls inflammation earlier in both systemic and burn tissue. We also found that PLM increased the level of TGF-β3 , which may be associated with the prevention of the development of hypertrophic scar in the burn wound, in the blood and burn tissue during this study.

Anahtar Kelime:

Pediyatrik yanık hastalarında polilaktik membran veya gümüşlü hidrofiber pansumanların kan ve dokuda interlökin-6, tümör nekrozis faktör-α, transforming büyüme faktörü-b3düzeylerine etkisi

Öz:

AMAÇ: Bu çalışmanın amacı, yanmış çocuklarda iki farklı yanık sargısının (gümüşlü hidrofiber [HFAg] ve polilaktik membran [PLM]), yanık sonrası gelişen enflamasyonun şiddetini gösteren önemli biyo belirteçler olan interlökin-6 (IL-6), tümör nekroz faktörü-alfa (TNF-α) ile yanık yara iyileşmesinde önemli rol oynayan dönüştürücü büyüme faktörü-b3 ’nın (TGF-b3 ) kanda ve dokuda tedavi sürecindeki değişim açısından incelenmesidir. GEREÇ VE YÖNTEM: Toplam vücut yüzey alanının %25–50'si ikinci derece kısmi kalınlıkta haşlanma yanıkları olan 1–16 yaş arası çocuklar, iki tedavi grubu çalışmaya dahil edildi. Gruplardan belirli aralıklarla PLM ile ve HFAg ile pansuman yapılan hastalardan 21 günlük tedavi döneminde 3–7–14–21. günlerde kan ve doku örnekleri alındı. Sağlıklı çocuklardan bir defa kan ve deri doku örneği alınarak kontrol grubu oluşturuldu. Gruplardan alınan kan ve doku örneklerinde IL-6, TNF-α, TGF-b3 düzeylerine bakıldı. Sonuçlar ististiksel olarak analiz edidi. BULGULAR: PLM grubunda IL-6 ve TNF-α seviyeleri, HFAg grubundan daha erken normal düzeye ulaştı. PLM grubunda, TGF-b3 seviyeleri diğer gruplara göre daha uzun süre yüksek kaldı. TARTIŞMA: Bu çalışmada, PLM'nin hem sistemik hem de yanık dokusunda enflamasyonu daha erken kontrol ettiğini bulduk. Ayrıca, PLM'nin, kanda ve yanık dokusunda hipertrofik skar gelişimini engelleyen TGF-b3 seviyesini artırdığını da bulduk.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Demircan M, GÜRÜNLÜOĞLU K, Gozukara Bag H, Koçbıyık A, Gül M, Uremis N, Gul S, GÜRÜNLÜOĞLU S, TÜRKÖZ Y, Taşçı A (2021). Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. , 122 - 131. 10.14744/tjtes.2020.30483
Chicago	Demircan Mehmet,GÜRÜNLÜOĞLU Kubilay,Gozukara Bag Harika Gozde,Koçbıyık Alper,Gül Mehmet,Uremis Nuray,Gul Semir,GÜRÜNLÜOĞLU SEMRA,TÜRKÖZ Yusuf,Taşçı Aytaç Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. (2021): 122 - 131. 10.14744/tjtes.2020.30483
MLA	Demircan Mehmet,GÜRÜNLÜOĞLU Kubilay,Gozukara Bag Harika Gozde,Koçbıyık Alper,Gül Mehmet,Uremis Nuray,Gul Semir,GÜRÜNLÜOĞLU SEMRA,TÜRKÖZ Yusuf,Taşçı Aytaç Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. , 2021, ss.122 - 131. 10.14744/tjtes.2020.30483
AMA	Demircan M,GÜRÜNLÜOĞLU K,Gozukara Bag H,Koçbıyık A,Gül M,Uremis N,Gul S,GÜRÜNLÜOĞLU S,TÜRKÖZ Y,Taşçı A Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. . 2021; 122 - 131. 10.14744/tjtes.2020.30483
Vancouver	Demircan M,GÜRÜNLÜOĞLU K,Gozukara Bag H,Koçbıyık A,Gül M,Uremis N,Gul S,GÜRÜNLÜOĞLU S,TÜRKÖZ Y,Taşçı A Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. . 2021; 122 - 131. 10.14744/tjtes.2020.30483
IEEE	Demircan M,GÜRÜNLÜOĞLU K,Gozukara Bag H,Koçbıyık A,Gül M,Uremis N,Gul S,GÜRÜNLÜOĞLU S,TÜRKÖZ Y,Taşçı A "Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns." , ss.122 - 131, 2021. 10.14744/tjtes.2020.30483
ISNAD	Demircan, Mehmet vd. "Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns". (2021), 122-131. https://doi.org/10.14744/tjtes.2020.30483

APA	Demircan M, GÜRÜNLÜOĞLU K, Gozukara Bag H, Koçbıyık A, Gül M, Uremis N, Gul S, GÜRÜNLÜOĞLU S, TÜRKÖZ Y, Taşçı A (2021). Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. Ulusal Travma ve Acil Cerrahi Dergisi, 27(1), 122 - 131. 10.14744/tjtes.2020.30483
Chicago	Demircan Mehmet,GÜRÜNLÜOĞLU Kubilay,Gozukara Bag Harika Gozde,Koçbıyık Alper,Gül Mehmet,Uremis Nuray,Gul Semir,GÜRÜNLÜOĞLU SEMRA,TÜRKÖZ Yusuf,Taşçı Aytaç Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. Ulusal Travma ve Acil Cerrahi Dergisi 27, no.1 (2021): 122 - 131. 10.14744/tjtes.2020.30483
MLA	Demircan Mehmet,GÜRÜNLÜOĞLU Kubilay,Gozukara Bag Harika Gozde,Koçbıyık Alper,Gül Mehmet,Uremis Nuray,Gul Semir,GÜRÜNLÜOĞLU SEMRA,TÜRKÖZ Yusuf,Taşçı Aytaç Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. Ulusal Travma ve Acil Cerrahi Dergisi, vol.27, no.1, 2021, ss.122 - 131. 10.14744/tjtes.2020.30483
AMA	Demircan M,GÜRÜNLÜOĞLU K,Gozukara Bag H,Koçbıyık A,Gül M,Uremis N,Gul S,GÜRÜNLÜOĞLU S,TÜRKÖZ Y,Taşçı A Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. Ulusal Travma ve Acil Cerrahi Dergisi. 2021; 27(1): 122 - 131. 10.14744/tjtes.2020.30483
Vancouver	Demircan M,GÜRÜNLÜOĞLU K,Gozukara Bag H,Koçbıyık A,Gül M,Uremis N,Gul S,GÜRÜNLÜOĞLU S,TÜRKÖZ Y,Taşçı A Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. Ulusal Travma ve Acil Cerrahi Dergisi. 2021; 27(1): 122 - 131. 10.14744/tjtes.2020.30483
IEEE	Demircan M,GÜRÜNLÜOĞLU K,Gozukara Bag H,Koçbıyık A,Gül M,Uremis N,Gul S,GÜRÜNLÜOĞLU S,TÜRKÖZ Y,Taşçı A "Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns." Ulusal Travma ve Acil Cerrahi Dergisi, 27, ss.122 - 131, 2021. 10.14744/tjtes.2020.30483
ISNAD	Demircan, Mehmet vd. "Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns". Ulusal Travma ve Acil Cerrahi Dergisi 27/1 (2021), 122-131. https://doi.org/10.14744/tjtes.2020.30483