TY  - JOUR
TI  - Impaction of the polylactic membrane or hydrofiber
with silver dressings on the interleukin-6, tumor necrosis
factor-α, transforming growth factor-b3
 levels in the blood
and tissues of pediatric patients with burns
AB  - BACKGROUND: We aimed to evaluate the effects of two different burn dressings, hydrofiber with a silver (HFAg) and polylactic
membrane (PLM), on altering the levels of important biomarkers Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α), Transforming
growth factor-β3
 (TGF-β3
) in blood and burnt tissue in children with second-degree burns.
METHODS: Children between the ages of one to 16 years, with 25–50% second-degree partial-thickness burns of the total body
surface area were included in this study. Patients in the PLM group were dressed with PLM in a typical way according to the manual. The
HFAg group was dressed with HFAg and a sterile cover. During and at the end of the 21-day treatment, blood and skin tissue samples
were taken from the two burn and control groups. IL-6, TNF-α, and TGF-β β3
 levels were evaluated in blood and tissue samples from
all groups, and the results were analyzed statistically.
RESULTS: In the PLM group, IL-6 and TNF-α levels decreased early days in both serum and tissue samples to reach normal ranges
compared with the HFAg group. In the PLM group, TGF-β3
 levels were elevated than in other groups for two weeks.
CONCLUSION: In this study, we found that PLM controls inflammation earlier in both systemic and burn tissue. We also found that
PLM increased the level of TGF-β3
, which may be associated with the prevention of the development of hypertrophic scar in the burn
wound, in the blood and burn tissue during this study.
AU  - Gül, Mehmet
AU  - Gozukara Bag, Harika Gozde
AU  - GÜRÜNLÜOĞLU, Kubilay
AU  - GÜRÜNLÜOĞLU, SEMRA
AU  - Uremis, Nuray
AU  - Gul, Semir
AU  - Taşçı, Aytaç
AU  - Demircan, Mehmet
AU  - TÜRKÖZ, Yusuf
AU  - Koçbıyık, Alper
DO  - 10.14744/tjtes.2020.30483
PY  - 2021
JO  - Ulusal Travma ve Acil Cerrahi Dergisi
VL  - 27
IS  - 1
SN  - 1306-696X
SP  - 122
EP  - 131
DB  - TRDizin
UR  - http://search/yayin/detay/517003
ER  -