HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates

FIRAT, Serap; FIRAT, Hikmet; KOKTURK, OGUZ; ÇİFTÇİ, Ulukavak Tansu

HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates

Oğuz KÖKTÜRK, (Gazi Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Ulukavak Tansu ÇİFTÇİ, (Gazi Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Hikmet FIRAT, (Gazi Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Serap FIRAT (Gazi Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Tüberküloz ve Toraks

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Yıl: 2005 Cilt: 53 Sayı: 1 Sayfa Aralığı: 34 - 39 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates

Öz:

Plevral efüzyonların tanısını koymada ilk basamak transüda-eksüda ayrımının yapılmasıdır. Çalışmamızda, plevral sıvıda hesaplanan HDL/LDL oranının transüda-eksüda ayrımındaki yerini araştırmayı amaçladık. Yirmisekizi transüda, 93’ü eksüda olmak üzere 121 plevral sıvı analiz edildi. Plevra sıvılarında kolesterol, HDL ve LDL düzeyleri ölçüldü. HDL/LDL oranı hesaplandı. HDL/LDL oranı transüdalarda eksüdalara oranla anlamlı ölçüde yüksek bulundu (p= 0.001). “Receiver Operating Characteristic (ROC)” eğrisi ile “cut-off” değer bulundu. HDL/LDL oranının maksimum sensitivite ve spesifisite ile transüda tanısı koyduran değeri saptandı. Transüdaları eksüdalardan ayıran HDL/LDL oranı 0.6 olarak belirlendi (sensitivite: %89, spesifisite %79). Plevral sıvılarda HDL ve LDL ölçümü ile HDL/LDL oranı hesaplanması, serum örneği almaya gerek kalmadan transüda-eksüda ayrımının yapılmasında uygun bir yöntemdir.

Anahtar Kelime: Eksuda ve transüdalar Kolesterol Lipoproteinler, LDL Lipoproteinler, HDL

Konular: Solunum Sistemi Kulak, Burun, Boğaz

HDL/LDL oranı: Transüda-eksüda ayrımında kullanışlı bir parametre

Öz:

The first diagnostic step in pleural effusions is the separation of transudates from exudates. We aimed in present study to investigate the value of HDL/LDL ratio for distinguishing between pleural exudates and transudates. Pleural fluids (PF) from 121 patients, including 28 transudates and 93 exudates were analyzed. The levels of cholesterol, HDL cholesterol and LDL cholesterol in PF were measured. The HDL/LDL ratio was calculated. HDL/LDL ratio found significantly higher in transudates than exudates (p= 0.001). Receiver operating characteristic (ROC) curves were generated and the cut off points determined to the highest level of accuracy and precision. The HDL/LDL ratio was to maximize sensitivity over specificity in the diagnosis of a transudative effusion. The usefulness of HDL/LDL ratio for identifying transudates was evaluated in terms of sensitivity and specificity. The value of pleural HDL/LDL ratio that best differentiated between transudates and exudates was 0.6 (sensitivity 89%, and specificity of 79%). Measurement of HDL and LDL in PF and calculating of HDL/LDL ratio can be proposed to aid for differentiation between pleural exudates and transudates with advantage of not requiring serum levels.

Anahtar Kelime: Exudates and Transudates Cholesterol Lipoproteins, LDL Lipoproteins, HDL

Konular: Solunum Sistemi Kulak, Burun, Boğaz

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	KOKTURK O, ÇİFTÇİ U, FIRAT H, FIRAT S (2005). HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. , 34 - 39.
Chicago	KOKTURK OGUZ,ÇİFTÇİ Ulukavak Tansu,FIRAT Hikmet,FIRAT Serap HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. (2005): 34 - 39.
MLA	KOKTURK OGUZ,ÇİFTÇİ Ulukavak Tansu,FIRAT Hikmet,FIRAT Serap HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. , 2005, ss.34 - 39.
AMA	KOKTURK O,ÇİFTÇİ U,FIRAT H,FIRAT S HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. . 2005; 34 - 39.
Vancouver	KOKTURK O,ÇİFTÇİ U,FIRAT H,FIRAT S HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. . 2005; 34 - 39.
IEEE	KOKTURK O,ÇİFTÇİ U,FIRAT H,FIRAT S "HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates." , ss.34 - 39, 2005.
ISNAD	KOKTURK, OGUZ vd. "HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates". (2005), 34-39.

APA	KOKTURK O, ÇİFTÇİ U, FIRAT H, FIRAT S (2005). HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. Tüberküloz ve Toraks, 53(1), 34 - 39.
Chicago	KOKTURK OGUZ,ÇİFTÇİ Ulukavak Tansu,FIRAT Hikmet,FIRAT Serap HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. Tüberküloz ve Toraks 53, no.1 (2005): 34 - 39.
MLA	KOKTURK OGUZ,ÇİFTÇİ Ulukavak Tansu,FIRAT Hikmet,FIRAT Serap HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. Tüberküloz ve Toraks, vol.53, no.1, 2005, ss.34 - 39.
AMA	KOKTURK O,ÇİFTÇİ U,FIRAT H,FIRAT S HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. Tüberküloz ve Toraks. 2005; 53(1): 34 - 39.
Vancouver	KOKTURK O,ÇİFTÇİ U,FIRAT H,FIRAT S HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates. Tüberküloz ve Toraks. 2005; 53(1): 34 - 39.
IEEE	KOKTURK O,ÇİFTÇİ U,FIRAT H,FIRAT S "HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates." Tüberküloz ve Toraks, 53, ss.34 - 39, 2005.
ISNAD	KOKTURK, OGUZ vd. "HDL/LDL ratio: a useful parameter for separation of pleural transudates from exudates". Tüberküloz ve Toraks 53/1 (2005), 34-39.