From Antiquity onwards the essence of the relation between God and nature is one of the significant questions of the intellectual history. The first thinker who places this question at the center of his system of thought is Xenophanes of Colophon though he is not the first to mention it. Although at first glance Xenophanes is associated with criticism of religion, this kind of approach fails to comprehend both his system of thought in its entirety and the motives behind his criticism of religion, and the sphere of philosophical problems at the time of early Greek philosophy of nature which is the period that philosophical activity in the classical sense began. In this period when all interest was directed to nature, it is difficult to understand Xenophanes’ ideas on nature and in this context his philosophical outlook without ascertaining his standpoint between the Milesians and the Eleatics. Thus, we cannot simply qualify Xenophanes only as a critic of religion as some commentators accept. Therefore, the main issue that we have to determine is how religion and nature or God and nature relate each other in Xenophanes’ thought. For, according to us, Ksenophanes is not purely a theolog but a real philosopher of religion, a physico-theolog, who tries to establish the relation between nature and God for the first time in the history of philosophy. So, in this article, we are going to analyze the problem of the relation between nature and God in terms of Xenophanes’ ideas who stands as the historical source of this problem in philosophy