Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT 
Parameters with Tumor Grade and Stage in Patients with Head and 
Neck Squamous Cell Carcinoma

Özdoğan, Özhan; Karabay, Nuri; Sarioglu, Sulen; BÜLBÜL, Hande Melike; BÜLBÜL, Ogün; DOGAN, ERSOY

doi:10.4274/mirt.galenos.2021.25633

Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma

Hande Melike BÜLBÜL, (Recep Tayyip Erdoğan Eğitim ve Araştırma Hastanesi, Radyoloji Kliniği, Rize, Türkiye)

Ogün BÜLBÜL, (Recep Tayyip Erdoğan Eğitim ve Araştırma Hastanesi, Nükleer Tıp Kliniği, Rize, Türkiye)

Sülen SARIOĞLU, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, İzmir, Türkiye)

Özhan ÖZDOĞAN, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, İzmir, Türkiye)

Ersoy DOĞAN, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, İzmir, Türkiye)

Nuri KARABAY (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, İzmir, Türkiye)

Molecular Imaging and Radionuclide Therapy

2 1

Yıl: 2021 Cilt: 30 Sayı: 3 Sayfa Aralığı: 177 - 186 Metin Dili: İngilizce DOI: 10.4274/mirt.galenos.2021.25633 İndeks Tarihi: 12-06-2022

Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma

Öz:

Objectives: Properties of head and neck squamous cell carcinoma (HNSCC) such as cellularity, vascularity, and glucose metabolism interact with each other. This study aimed to investigate the associations between diffusion-weighted imaging (DWI), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and positron emission tomography/computed tomography (PET/CT) in patients with HNSCC. Methods: Fourteen patients who were diagnosed with HNSCC were investigated using DCE-MRI, DCE, and 18fluoride-fluorodeoxyglucose PET/CT and evaluated retrospectively. Ktrans, Kep, Ve, and initial area under the curve (iAUC) parameters from DCE-MRI, ADCmax, ADCmean, and ADCmin parameters from DWI, and maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) parameters from PET were obtained. Spearman’s correlation coefficient was used to analyze associations between these parameters. In addition, these parameters were grouped according to tumor grade and T and N stages, and the difference between the groups was evaluated using the Mann-Whitney U test. Results: Correlations at varying degrees were observed in the parameters investigated. ADCmean moderately correlated with Ve (p=0.035; r=0.566). Ktrans inversely correlated with SUVmax (p=0.017; r=-0.626). iAUC inversely correlated with SUVmax, SUVmean, TLG, and MTV (p<0.05, r≤-0.700). MTV (40% threshold) was significantly higher in T4 tumors than in T1-3 tumors (p=0.020). No significant difference was found in the grouping made according to tumor grade and N stage in terms of these parameters. Conclusion: Tumor cellularity, vascular permeability, and glucose metabolism had significant correlations at different degrees. Furthermore, MTV may be useful in predicting T4 tumors.

Anahtar Kelime:

Baş Boyun Yassı Hücreli Kanser Hastalarında Tümör Derecesi ve Evre ile DK-MRG, DAGve 18F-FDG PET/BT Parametrelerinin İlişkisi

Öz:

Amaç: Baş boyun yassı hücreli karsinomunun (BBYHK) hücresellik, vaskülarite ve glukoz metabolizması gibi özellikleri birbirleri ile etkileşim içerisindedir. Bu çalışmanın amacı BBYHK hastalarında difüzyon ağırlıklı görüntüleme (DAG), dinamik kontrastlı manyetik rezonans görüntüleme (DK-MRG) ve pozitron emisyon tomografisi/bilgisayarlı tomografi (PET/BT) arasındaki ilişkinin araştırılmasıdır. Yöntem: BBYHK tanısı almış ve DAG, DK-MRG ve 18flor-florodeoksiglukoz ( 18F-FDG) ile görüntüleme yapılmış 14 hasta retrospektif olarak değerlendirildi. DK-MRG’den Ktrans, Kep, Ve iAUC; DAG’den ADCmaks, ADCmean and ADCmin ve 18F-FDG PET/BT’den SUVmaks, SUVmean, metabolik tümör hacmi (MTV) and toplam lezyon glikolizi (TLG) parametreleri elde edildi. Bu parametreler arasındaki ilişki Spearman korelasyon katsayısı kullanılarak değerlendirildi. Ayrıca bu parametreler tümör derecesi, T ve N evresine göre gruplandırılarak gruplar arasındaki ilişki Mann-Whitney U testi kullanılarak analiz edildi. Bulgular: İncelenen parametreler arasında değişen düzeylerde korelasyonlar gözlendi. ADCmean ve Ve arasında orta düzeyde pozitif korelasyon saptandı (p=0,035; r=0,566). Ktrans ile SUVmaks’ın negatif korelasyon gösterdiği (p=0,017; r=-0,626), iAUC ile SUVmaks, SUVmean, TLG ve MTV arasında negatif yönde güçlü korelasyon olduğu gözlendi (p<0,05, r≤-0,700). MTV (%40 x SUVmaks eşik değer) T4 tümörlerde T1-3 tümörlere kıyasla istatistiksel olarak anlamlı düzeyde yüksekti (p=0,020). Tümör derecesi ve N evresine göre yapılan gruplamada parametreler arasında anlamlı fark saptanmadı. Sonuç: Tümörün hücreselliği, vasküler permeabilite ve glukoz metabolizması farklı derecelerde anlamlı korelasyonlar gösterdi. Ayrıca, MTV değeri T4 tümörleri tahmin etmede faydalı olabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BÜLBÜL H, BÜLBÜL O, Sarioglu S, Özdoğan Ö, DOGAN E, Karabay N (2021). Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. , 177 - 186. 10.4274/mirt.galenos.2021.25633
Chicago	BÜLBÜL Hande Melike,BÜLBÜL Ogün,Sarioglu Sulen,Özdoğan Özhan,DOGAN ERSOY,Karabay Nuri Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. (2021): 177 - 186. 10.4274/mirt.galenos.2021.25633
MLA	BÜLBÜL Hande Melike,BÜLBÜL Ogün,Sarioglu Sulen,Özdoğan Özhan,DOGAN ERSOY,Karabay Nuri Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. , 2021, ss.177 - 186. 10.4274/mirt.galenos.2021.25633
AMA	BÜLBÜL H,BÜLBÜL O,Sarioglu S,Özdoğan Ö,DOGAN E,Karabay N Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. . 2021; 177 - 186. 10.4274/mirt.galenos.2021.25633
Vancouver	BÜLBÜL H,BÜLBÜL O,Sarioglu S,Özdoğan Ö,DOGAN E,Karabay N Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. . 2021; 177 - 186. 10.4274/mirt.galenos.2021.25633
IEEE	BÜLBÜL H,BÜLBÜL O,Sarioglu S,Özdoğan Ö,DOGAN E,Karabay N "Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma." , ss.177 - 186, 2021. 10.4274/mirt.galenos.2021.25633
ISNAD	BÜLBÜL, Hande Melike vd. "Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma". (2021), 177-186. https://doi.org/10.4274/mirt.galenos.2021.25633

APA	BÜLBÜL H, BÜLBÜL O, Sarioglu S, Özdoğan Ö, DOGAN E, Karabay N (2021). Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. Molecular Imaging and Radionuclide Therapy, 30(3), 177 - 186. 10.4274/mirt.galenos.2021.25633
Chicago	BÜLBÜL Hande Melike,BÜLBÜL Ogün,Sarioglu Sulen,Özdoğan Özhan,DOGAN ERSOY,Karabay Nuri Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. Molecular Imaging and Radionuclide Therapy 30, no.3 (2021): 177 - 186. 10.4274/mirt.galenos.2021.25633
MLA	BÜLBÜL Hande Melike,BÜLBÜL Ogün,Sarioglu Sulen,Özdoğan Özhan,DOGAN ERSOY,Karabay Nuri Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. Molecular Imaging and Radionuclide Therapy, vol.30, no.3, 2021, ss.177 - 186. 10.4274/mirt.galenos.2021.25633
AMA	BÜLBÜL H,BÜLBÜL O,Sarioglu S,Özdoğan Ö,DOGAN E,Karabay N Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. Molecular Imaging and Radionuclide Therapy. 2021; 30(3): 177 - 186. 10.4274/mirt.galenos.2021.25633
Vancouver	BÜLBÜL H,BÜLBÜL O,Sarioglu S,Özdoğan Ö,DOGAN E,Karabay N Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma. Molecular Imaging and Radionuclide Therapy. 2021; 30(3): 177 - 186. 10.4274/mirt.galenos.2021.25633
IEEE	BÜLBÜL H,BÜLBÜL O,Sarioglu S,Özdoğan Ö,DOGAN E,Karabay N "Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma." Molecular Imaging and Radionuclide Therapy, 30, ss.177 - 186, 2021. 10.4274/mirt.galenos.2021.25633
ISNAD	BÜLBÜL, Hande Melike vd. "Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma". Molecular Imaging and Radionuclide Therapy 30/3 (2021), 177-186. https://doi.org/10.4274/mirt.galenos.2021.25633