TY  - JOUR
TI  - Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT 
Parameters with Tumor Grade and Stage in Patients with Head and 
Neck Squamous Cell Carcinoma
AB  - Objectives: Properties of head and neck squamous cell carcinoma (HNSCC) such as cellularity, vascularity, and glucose metabolism interact with 
each other. This study aimed to investigate the associations between diffusion-weighted imaging (DWI), dynamic contrast-enhanced magnetic 
resonance imaging (DCE-MRI), and positron emission tomography/computed tomography (PET/CT) in patients with HNSCC.
Methods: Fourteen patients who were diagnosed with HNSCC were investigated using DCE-MRI, DCE, and 18fluoride-fluorodeoxyglucose PET/CT 
and evaluated retrospectively. Ktrans, Kep, Ve, and initial area under the curve (iAUC) parameters from DCE-MRI, ADCmax, ADCmean, and ADCmin
parameters from DWI, and maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis 
(TLG) parameters from PET were obtained. Spearman’s correlation coefficient was used to analyze associations between these parameters. In 
addition, these parameters were grouped according to tumor grade and T and N stages, and the difference between the groups was evaluated 
using the Mann-Whitney U test.
Results: Correlations at varying degrees were observed in the parameters investigated. ADCmean moderately correlated with Ve (p=0.035; r=0.566). 
Ktrans inversely correlated with SUVmax (p=0.017; r=-0.626). iAUC inversely correlated with SUVmax, SUVmean, TLG, and MTV (p<0.05, r≤-0.700). 
MTV (40% threshold) was significantly higher in T4 tumors than in T1-3 tumors (p=0.020). No significant difference was found in the grouping 
made according to tumor grade and N stage in terms of these parameters.
Conclusion: Tumor cellularity, vascular permeability, and glucose metabolism had significant correlations at different degrees. Furthermore, MTV 
may be useful in predicting T4 tumors.
AU  - Özdoğan, Özhan
AU  - Karabay, Nuri
AU  - Sarioglu, Sulen
AU  - BÜLBÜL, Hande Melike
AU  - BÜLBÜL, Ogün
AU  - DOGAN, ERSOY
DO  - 10.4274/mirt.galenos.2021.25633
PY  - 2021
JO  - Molecular Imaging and Radionuclide Therapy
VL  - 30
IS  - 3
SN  - 2146-1414
SP  - 177
EP  - 186
DB  - TRDizin
UR  - http://search/yayin/detay/517376
ER  -