TY  - JOUR
TI  - Effect of Tocilizumab on Acinetobacter baumannii Lung Infection in
an Immunosuppressed Rat Model
AB  - Our study aimed to investigate effect of tocilizumab on the lung tissue in the presence of Acinetobacter baumannii infection in immunosuppressed
rats. A forty-eight female Wistar albino rats were divided equally into eight groups: Group 1: Healthy (H), Group 2: Immunosuppressed (IM), Group
3: Healthy rats given A. baumannii bacteria (H+BAC), Group 4: Immunosuppressed rats given A. baumannii bacteria (IM+BAC), Group 5: Healthy rats
given tocilizumab (H+TCZ), Group 6: Immunosuppressed rats given tocilizumab (IM+TCZ), Group 7: Healthy rats given A. baumannii bacteria and
tocilizumab (H+BAC+TCZ), Group 8: Immunosuppressed rats given tocilizumab and A. baumannii bacteria (IM+BAC+TCZ). Fourteen days after the
immunosuppression of group 2, 4, 6 and 8 with hydrocortisone, group 3, 4, 7 and 8 were A. baumannii was dropped into the trachea. One hour after
A. baumannii application, TCZ was administered to Groups 5, 6, 7 and 8. NF-κB, IL-6 and NLRP3 mRNA expressions were decreased in the IM group
compared to the healthy group (P<0.05). Although NF-κB, IL-6 and NLRP3 mRNA expression decreased in the IM+TCZ group compared to the healthy
group (P<0.05) NF-κB, IL-6 and NLRP3 mRNA expression increased in the H+TCZ group (P<0.05). Despite decreasing cytokines, A. baumannii has been
shown to increase infection-related lung injury. This suggests that in patients currently or recently using steroids, tocilizumab may increase organ
damage due to opportunistic infection.
AU  - Cinisli, Kağan Tolga
AU  - Keskin, Halil
AU  - ÇELEBİ, Özgür
AU  - halıcı, iclal
AU  - Halici, Zekai
AU  - Akgün, Nurullah
AU  - CINAR, Irfan
AU  - yildirim, Serkan
AU  - ÇELEBİ, Demet
DO  - 10.9775/kvfd.2021.26491
PY  - 2022
JO  - Kafkas Üniversitesi Veteriner Fakültesi Dergisi
VL  - 28
IS  - 1
SN  - 1300-6045
SP  - 87
EP  - 96
DB  - TRDizin
UR  - http://search/yayin/detay/517691
ER  -