Is Gestational Diabetes Mellitus Associated with the
Metabolic Syndrome?

BULBUL, Mehmet; Özerkan, Kemal; Arslan Yıldırım, Emel; Develioğlu, Osman Haldun

doi:10.5505/kjms.2019.87528

Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?

Emel ARSLAN YILDIRIM, (Health Sciences University, Bursa Educational Research Hospital, Bursa, Türkiye)

Mehmet BÜLBÜL, (Department of Obstetrics and Gynecology, Adıyaman University Faculty of Medicine, AdıyamanTürkiye)

Kemal ÖZERKAN, (Department of Obstetrics and Gynecology, Uludağ University Faculty of Medicine, Bursa, Türkiye)

Osman Haldun DEVELİOĞLU (Assisted Reproductive Treatment (ART) Center, Bursa, Turkey)

Kafkas Tıp Bilimleri Dergisi

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Yıl: 2019 Cilt: 9 Sayı: 2 Sayfa Aralığı: 110 - 116 Metin Dili: İngilizce DOI: 10.5505/kjms.2019.87528 İndeks Tarihi: 13-06-2022

Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?

Öz:

Aim: Gestational Diabetes Mellitus (GDM) accounts for 1-14% of pregnancies. Insulin resistance (IR) plays a role in pathophysiology as it is in Polycystic Ovary Syndrome (PCOS) and Metabolic Syndrome (MS). Therefore, these three clinical situations are thought to be related to each other. Material and Method: In this study, 27 women who were diagnosed with GDM and 30 healthy women were compared in terms of PCOS, MS and IR. Results: Weight and body mass index (BMI), waist and hip circumference were higher in the GDM group than in the control group (respectively 69.0±11,5 kg vs 62.0±10,3 kg, p:0,01; 27.0±4,7 kg/ m2 vs 23.0±3,5 kg/m2 , p:0,001; 82.0±8,5 cm vs 74.0±7,5 cm, p<0,001; 103.0±8,1 cm vs 98.0±8,7 cm, p:0,02). MS frequency was statistically higher in the GDM group than in the control group. The waist circumference, blood pressure, fasting blood sugar and triglyceride levels were higher than the control group. (respectively 55,6% vs 20%, p:0,006; 18,5% vs 0%, p:0,01; 29,6% vs 6,7%, p:0,02; 48,1% vs 10%, p: 0,002). HDL cholesterol levels were not statistically different between the groups (p> 0.05). When the threshold for HOMA was taken as 2.24, more insulin resistance was detected in the GDM group than in the control group (respectively 48,1% vs 20,0%, p: 0,02). Conclusion: As in GDM, the common problem in MS and PCOS is IR. As shown in many studies, in our study, MS was found higher in the GDM group. Therefore, metabolic syndrome should be screened in patients with GDM.

Anahtar Kelime:

Gestasyonel Diyabet, Metabolik Sendrom ile İlişkili midir?

Öz:

Amaç: Gestasyonel Diabetes Mellitus (GDM) gebeliklerin %1- 14’ünü görülür. Polikistik over sendromu (PCOS) ve metabolik sendromda (MS) olduğu gibi patofizyolojisinde insülin direnci (IR) rol alır. Bundan dolayı bu üç klinik durumun birbiriyle ilişkili olduğu düşünülmektedir. Materyal ve Metot: Bu çalışmada GDM tanısı almış 27 kadın ve sağlıklı 30 kadın PCOS, MS ve IR açısından karşılaştırılmıştır. Bulgular: GDM grubunda kilo ve vücut kitle indeksi (BMI), bel ve kalça çevreleri kontrol grubundan daha yüksekti (sırasıyla 69.0±11,5 kg vs 62.0±10,3 kg, p:0,01; 27.0±4,7 kg/m2 vs 23.0±3,5 kg/m2 , p:0,001; 82.0±8,5 cm vs 74.0±7,5 cm, p<0,001; 103.0±8,1 cm vs 98.0±8,7 cm, p:0,02). MS sıklığı GDM grubunda kontrol grubuna göre istatistiksel anlamlı olarak daha yüksekti. Bel çevresi, kan basıncı, açlık kan şekeri ve trigliserid düzeyleri yüksek olan hasta sayısı kontrol grubuna göre daha fazlaydı (sırasıyla %55,6 vs %20, p:0,006; %18,5 vs %0, p:0,01; %29,6 vs %6,7, p:0,02; %48,1 vs %10, p: 0,002). HDL kolesterol düzeyi açısından ise gruplar arasında istatistiksel olarak fark saptanmadı (p>0,05). HOMA için eşik değer 2.24 olarak alındığında GDM grubunda kontrol grubundan daha fazla insülin direnci saptandı sırasıyla (sırasıyla %48,1 vs %20 ,0, p: 0,02). Sonuç: GDM’de olduğu gibi MS ve PCOS’ta ortak problem IR’dır. Birçok çalışmada gösterildiği gibi bizim çalışmamızda da MS, GDM grubunda daha yüksek saptandı. Bundan dolayı GDM öyküsü olan hastalarda metabolik sendrom taranmalıdır

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Arslan Yıldırım E, BULBUL M, Özerkan K, Develioğlu O (2019). Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. , 110 - 116. 10.5505/kjms.2019.87528
Chicago	Arslan Yıldırım Emel,BULBUL Mehmet,Özerkan Kemal,Develioğlu Osman Haldun Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. (2019): 110 - 116. 10.5505/kjms.2019.87528
MLA	Arslan Yıldırım Emel,BULBUL Mehmet,Özerkan Kemal,Develioğlu Osman Haldun Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. , 2019, ss.110 - 116. 10.5505/kjms.2019.87528
AMA	Arslan Yıldırım E,BULBUL M,Özerkan K,Develioğlu O Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. . 2019; 110 - 116. 10.5505/kjms.2019.87528
Vancouver	Arslan Yıldırım E,BULBUL M,Özerkan K,Develioğlu O Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. . 2019; 110 - 116. 10.5505/kjms.2019.87528
IEEE	Arslan Yıldırım E,BULBUL M,Özerkan K,Develioğlu O "Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?." , ss.110 - 116, 2019. 10.5505/kjms.2019.87528
ISNAD	Arslan Yıldırım, Emel vd. "Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?". (2019), 110-116. https://doi.org/10.5505/kjms.2019.87528

APA	Arslan Yıldırım E, BULBUL M, Özerkan K, Develioğlu O (2019). Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. Kafkas Tıp Bilimleri Dergisi, 9(2), 110 - 116. 10.5505/kjms.2019.87528
Chicago	Arslan Yıldırım Emel,BULBUL Mehmet,Özerkan Kemal,Develioğlu Osman Haldun Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. Kafkas Tıp Bilimleri Dergisi 9, no.2 (2019): 110 - 116. 10.5505/kjms.2019.87528
MLA	Arslan Yıldırım Emel,BULBUL Mehmet,Özerkan Kemal,Develioğlu Osman Haldun Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. Kafkas Tıp Bilimleri Dergisi, vol.9, no.2, 2019, ss.110 - 116. 10.5505/kjms.2019.87528
AMA	Arslan Yıldırım E,BULBUL M,Özerkan K,Develioğlu O Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. Kafkas Tıp Bilimleri Dergisi. 2019; 9(2): 110 - 116. 10.5505/kjms.2019.87528
Vancouver	Arslan Yıldırım E,BULBUL M,Özerkan K,Develioğlu O Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?. Kafkas Tıp Bilimleri Dergisi. 2019; 9(2): 110 - 116. 10.5505/kjms.2019.87528
IEEE	Arslan Yıldırım E,BULBUL M,Özerkan K,Develioğlu O "Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?." Kafkas Tıp Bilimleri Dergisi, 9, ss.110 - 116, 2019. 10.5505/kjms.2019.87528
ISNAD	Arslan Yıldırım, Emel vd. "Is Gestational Diabetes Mellitus Associated with the Metabolic Syndrome?". Kafkas Tıp Bilimleri Dergisi 9/2 (2019), 110-116. https://doi.org/10.5505/kjms.2019.87528