Factors that affect placental retinol transfer in preterm infants and mothers with retinol
deficiency

KARA, MUSTAFA; Ozturk, Nurinnisa; Dilek, Dilara; Ejder Tekgündüz, Sibel; TEKGÜNDÜZ, KADİR ŞERAFETTİN

doi:10.55730/1300-0144.5315

Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency

Kadir Şerafettin TEKGÜNDÜZ, (Atatürk Üniversitesi, Tıp Fakültesi, Pediatri Bölümü, Neonatoloji Anabilim Dalı, Erzurum, Türkiye)

Dilara DİLEK, (Atatürk Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Erzurum, Türkiye)

Mustafa KARA, (Atatürk Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Bölümü, Neonatoloji Anabilim Dalı, Erzurum, Türkiye)

Nurinnisa ÖZTÜRK, (Atatürk Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Erzurum, Türkiye)

Sibel Ejder TEKGÜNDÜZ (Erzurum Bölge Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Erzurum, Türkiye)

Turkish Journal of Medical Sciences

3 0

Yıl: 2022 Cilt: 52 Sayı: 2 Sayfa Aralığı: 294 - 302 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5315 İndeks Tarihi: 14-06-2022

Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency

Öz:

Background/aim: The retinol level and retinol delivery to the placenta may vary depending on various factors involving the mother and newborn. The present study evaluates the factors affecting retinol levels in newborns and the transplacental retinol passage in preterm newborns. Materials and methods: In this prospective cohort study, the retinol and retinol binding protein (RBP) in the umbilical cord blood of 44 preterm infants with a gestation age of <30 weeks were studied. Serum retinol and RBP levels were determined using an enzyme-linked immunosorbent assay, and the rate of transplacental retinol passage was calculated. The demographic data of mothers and newborns, the use of vitamins by the mother, the application of antenatal corticosteroids, and any diseases diagnosed during pregnancy were recorded. An evaluation was made of the retinol, RBP, and other factors of the mother and newborn affecting transplacental retinol passage. Results: A retinol deficiency was identified in 68.2% of the study population. Retinol and RBP levels in umbilical cord blood (273.7 ± 150.03 ng/mL, 7.88 ± 5.6 ng/mL, respectively) were significantly higher than the corresponding levels in the mother (206.4 ± 86.26 ng/ mL, 1.04 ± 0.97 ng/mL, respectively). Umbilical cord blood retinol deficiency was more common in the male participants, while the transplacental retinol passage rate was higher in females. The umbilical cord blood RBP was found to be lower in those administered antenatal corticosteroids than in those who did not receive antenatal corticosteroids, and median maternal RBP levels were lower in patients with anemia and pregnancy-induced hypertension than in those with no disease. Conclusion: Placental adaptation and contributing factors may vary in populations with severe retinol deficiency. The finding of significantly increased cord blood retinol levels when compared to maternal retinol levels in the present study suggests that some compensatory mechanisms, such as increased placental RBP levels, support the presentation of retinol to the fetus, even if the mother has a retinol deficiency.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TEKGÜNDÜZ K, Dilek D, KARA M, Ozturk N, Ejder Tekgündüz S (2022). Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. , 294 - 302. 10.55730/1300-0144.5315
Chicago	TEKGÜNDÜZ KADİR ŞERAFETTİN,Dilek Dilara,KARA MUSTAFA,Ozturk Nurinnisa,Ejder Tekgündüz Sibel Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. (2022): 294 - 302. 10.55730/1300-0144.5315
MLA	TEKGÜNDÜZ KADİR ŞERAFETTİN,Dilek Dilara,KARA MUSTAFA,Ozturk Nurinnisa,Ejder Tekgündüz Sibel Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. , 2022, ss.294 - 302. 10.55730/1300-0144.5315
AMA	TEKGÜNDÜZ K,Dilek D,KARA M,Ozturk N,Ejder Tekgündüz S Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. . 2022; 294 - 302. 10.55730/1300-0144.5315
Vancouver	TEKGÜNDÜZ K,Dilek D,KARA M,Ozturk N,Ejder Tekgündüz S Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. . 2022; 294 - 302. 10.55730/1300-0144.5315
IEEE	TEKGÜNDÜZ K,Dilek D,KARA M,Ozturk N,Ejder Tekgündüz S "Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency." , ss.294 - 302, 2022. 10.55730/1300-0144.5315
ISNAD	TEKGÜNDÜZ, KADİR ŞERAFETTİN vd. "Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency". (2022), 294-302. https://doi.org/10.55730/1300-0144.5315

APA	TEKGÜNDÜZ K, Dilek D, KARA M, Ozturk N, Ejder Tekgündüz S (2022). Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. Turkish Journal of Medical Sciences, 52(2), 294 - 302. 10.55730/1300-0144.5315
Chicago	TEKGÜNDÜZ KADİR ŞERAFETTİN,Dilek Dilara,KARA MUSTAFA,Ozturk Nurinnisa,Ejder Tekgündüz Sibel Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. Turkish Journal of Medical Sciences 52, no.2 (2022): 294 - 302. 10.55730/1300-0144.5315
MLA	TEKGÜNDÜZ KADİR ŞERAFETTİN,Dilek Dilara,KARA MUSTAFA,Ozturk Nurinnisa,Ejder Tekgündüz Sibel Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. Turkish Journal of Medical Sciences, vol.52, no.2, 2022, ss.294 - 302. 10.55730/1300-0144.5315
AMA	TEKGÜNDÜZ K,Dilek D,KARA M,Ozturk N,Ejder Tekgündüz S Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. Turkish Journal of Medical Sciences. 2022; 52(2): 294 - 302. 10.55730/1300-0144.5315
Vancouver	TEKGÜNDÜZ K,Dilek D,KARA M,Ozturk N,Ejder Tekgündüz S Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency. Turkish Journal of Medical Sciences. 2022; 52(2): 294 - 302. 10.55730/1300-0144.5315
IEEE	TEKGÜNDÜZ K,Dilek D,KARA M,Ozturk N,Ejder Tekgündüz S "Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency." Turkish Journal of Medical Sciences, 52, ss.294 - 302, 2022. 10.55730/1300-0144.5315
ISNAD	TEKGÜNDÜZ, KADİR ŞERAFETTİN vd. "Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency". Turkish Journal of Medical Sciences 52/2 (2022), 294-302. https://doi.org/10.55730/1300-0144.5315