TY  - JOUR
TI  - Clinical characteristics, late effects and outcomes in
pineoblastomas in children: a single center experience
AB  - Background. Pineoblastomas (PB) are rare tumors of the central nervous system and are more common in
children. There is no consensus about standard of care. The objective of this study is to analyze the outcome of
children with PB.
Methods. Six patients with PB who were diagnosed between 1990-2012 were evaluated retrospectively.
Demographics, age of diagnosis, first complaint, tumor region, diagnosis type, seeding metastasis to the spinal
axis or cerebrospinal fluid (CSF), treatment and survival of these patients were recorded.
Results. Three patients had subtotal resection and all patients received chemotherapy and craniospinal
irradiation (CSI) after diagnosis. Median follow-up after treatment was 5.5 (range:1-19) years. Two patients
are alive with no evidence of disease for 7.5 and 10 years, one of whom was diagnosed with papillary thyroid
carcinoma 9.5 years after treatment. One of the patients who died had lived for 19 years after diagnosis.
Conclusions. Pineoblastomas are rare but very aggressive tumors; more effective treatment strategies are
needed. Survivors should be followed up for late effects such as second malignancies and endocrine deficiencies.
AU  - Kebudi, Abut
AU  - KEBUDİ, Rejin
AU  - Koc, Basak
AU  - GÖRGÜN, Ömer
AU  - WOLFF, Johannes E
AU  - DARENDELİLER, Emin
DO  - 10.24953/turkjped.2021.06.002
PY  - 2021
JO  - Turkish Journal of Pediatrics
VL  - 63
IS  - 6
SN  - 0041-4301
SP  - 955
EP  - 961
DB  - TRDizin
UR  - http://search/yayin/detay/518264
ER  -