Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura
Yıl: 2021 Cilt: 63 Sayı: 6 Sayfa Aralığı: 962 - 969 Metin Dili: İngilizce DOI: 10.24953/turkjped.2021.06.003 İndeks Tarihi: 14-06-2022
Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura
Öz: Background. Changes in oxidative stress and thiol / disulfide balance are thought to play a role in the
pathogenesis of idiopathic thrombocytopenic purpura (ITP). Our study investigates total oxidant level (TOS),
total antioxidant level (TAS), oxidative stress index (OSI) levels and thiol / disulfide balance in pediatric patients
with acute and chronic ITP.
Methods. Thirty four patients with acute ITP, eighteen patients with chronic ITP and thirty three healthy
children (control) were included. TOS, TAS, OSI, thiol / disulfide balance were analyzed.
Results. In acute ITP, TAS levels were lower than chronic ITP and control, TOS and OSI levels were higher
than control, and native thiol level was lower than chronic ITP (p <0.05). In acute ITP; disulfide level, disulfide
/ native thiol and disulfide / total thiol ratios were higher than chronic ITP and control, and native thiol / total
thiol ratio was lower than chronic ITP and control group (p = 0.038, p = 0.018, respectively). TOS and OSI levels
of the chronic ITP were higher than the control group (p <0.05).
Conclusions. The results of this study have shown that oxidative stress increases in children with acute ITP and
chronic ITP, that thiol / disulfide balance is disrupted in favor of disulfide in acute ITP, and that thiol / disulfide
balance isn’t disrupted in chronic ITP patients whose platelet count is close to normal and who don’t require
treatment.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | DÜZENLİ KAR Y, Özdemir Z, BÖR Ö (2021). Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. , 962 - 969. 10.24953/turkjped.2021.06.003 |
| Chicago | DÜZENLİ KAR Yeter,Özdemir Zeynep Canan,BÖR Özcan Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. (2021): 962 - 969. 10.24953/turkjped.2021.06.003 |
| MLA | DÜZENLİ KAR Yeter,Özdemir Zeynep Canan,BÖR Özcan Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. , 2021, ss.962 - 969. 10.24953/turkjped.2021.06.003 |
| AMA | DÜZENLİ KAR Y,Özdemir Z,BÖR Ö Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. . 2021; 962 - 969. 10.24953/turkjped.2021.06.003 |
| Vancouver | DÜZENLİ KAR Y,Özdemir Z,BÖR Ö Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. . 2021; 962 - 969. 10.24953/turkjped.2021.06.003 |
| IEEE | DÜZENLİ KAR Y,Özdemir Z,BÖR Ö "Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura." , ss.962 - 969, 2021. 10.24953/turkjped.2021.06.003 |
| ISNAD | DÜZENLİ KAR, Yeter vd. "Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura". (2021), 962-969. https://doi.org/10.24953/turkjped.2021.06.003 |
| APA | DÜZENLİ KAR Y, Özdemir Z, BÖR Ö (2021). Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. Turkish Journal of Pediatrics, 63(6), 962 - 969. 10.24953/turkjped.2021.06.003 |
| Chicago | DÜZENLİ KAR Yeter,Özdemir Zeynep Canan,BÖR Özcan Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. Turkish Journal of Pediatrics 63, no.6 (2021): 962 - 969. 10.24953/turkjped.2021.06.003 |
| MLA | DÜZENLİ KAR Yeter,Özdemir Zeynep Canan,BÖR Özcan Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. Turkish Journal of Pediatrics, vol.63, no.6, 2021, ss.962 - 969. 10.24953/turkjped.2021.06.003 |
| AMA | DÜZENLİ KAR Y,Özdemir Z,BÖR Ö Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. Turkish Journal of Pediatrics. 2021; 63(6): 962 - 969. 10.24953/turkjped.2021.06.003 |
| Vancouver | DÜZENLİ KAR Y,Özdemir Z,BÖR Ö Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura. Turkish Journal of Pediatrics. 2021; 63(6): 962 - 969. 10.24953/turkjped.2021.06.003 |
| IEEE | DÜZENLİ KAR Y,Özdemir Z,BÖR Ö "Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura." Turkish Journal of Pediatrics, 63, ss.962 - 969, 2021. 10.24953/turkjped.2021.06.003 |
| ISNAD | DÜZENLİ KAR, Yeter vd. "Thiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura". Turkish Journal of Pediatrics 63/6 (2021), 962-969. https://doi.org/10.24953/turkjped.2021.06.003 |
