TY  - JOUR
TI  - Thiol / disulfide balance and oxidative stress parameters
in pediatric patients diagnosed with acute and chronic
idiopathic thrombocytopenic purpura
AB  - Background. Changes in oxidative stress and thiol / disulfide balance are thought to play a role in the
pathogenesis of idiopathic thrombocytopenic purpura (ITP). Our study investigates total oxidant level (TOS),
total antioxidant level (TAS), oxidative stress index (OSI) levels and thiol / disulfide balance in pediatric patients
with acute and chronic ITP.
Methods. Thirty four patients with acute ITP, eighteen patients with chronic ITP and thirty three healthy
children (control) were included. TOS, TAS, OSI, thiol / disulfide balance were analyzed.
Results. In acute ITP, TAS levels were lower than chronic ITP and control, TOS and OSI levels were higher
than control, and native thiol level was lower than chronic ITP (p <0.05). In acute ITP; disulfide level, disulfide
/ native thiol and disulfide / total thiol ratios were higher than chronic ITP and control, and native thiol / total
thiol ratio was lower than chronic ITP and control group (p = 0.038, p = 0.018, respectively). TOS and OSI levels
of the chronic ITP were higher than the control group (p <0.05).
Conclusions. The results of this study have shown that oxidative stress increases in children with acute ITP and
chronic ITP, that thiol / disulfide balance is disrupted in favor of disulfide in acute ITP, and that thiol / disulfide
balance isn’t disrupted in chronic ITP patients whose platelet count is close to normal and who don’t require
treatment.
AU  - DÜZENLİ KAR, Yeter
AU  - Özdemir, Zeynep Canan
AU  - BÖR, Özcan
DO  - 10.24953/turkjped.2021.06.003
PY  - 2021
JO  - Turkish Journal of Pediatrics
VL  - 63
IS  - 6
SN  - 0041-4301
SP  - 962
EP  - 969
DB  - TRDizin
UR  - http://search/yayin/detay/518267
ER  -