TY  - JOUR
TI  - Cost and length of hospital stay for healthcare facility-
onset Clostridioides Difficile infection in pediatric wards: a
prospective cohort analysis
AB  - Background. Clostridioides difficile (C. difficile) is a well-known causative agent of healthcare associated infection,
it increases medical cost besides increasing morbidity and mortality. This study was conducted to determine the
incidence, and economic burden of healthcare facility-onset C. difficile infection (HO-CDI) in children.
Methods. Data was acquired with a prospective cohort study conducted in pediatric wards of a tertiary
university hospital between August 2015 to August 2016. The HO-CDI was defined as diarrhea that began after
48 hours of admission with a positive cytotoxic stool assay for the presence of toxin A and/or B of C. difficile.
Results. In the 3172 admissions in one year, 212 (7%) healthcare associated diarrhea (HAD) episodes were
observed, in 25 (12%) of them C. difficile was identified in which 6 (25%) cases <2-year-old. The incidence of HO-
CDI was estimated as 8.8/10,000 patient-days. Cases with HO-CDI (n=19) were compared with cases with non-
CDI-HAD (n=102); the presence of one of the risk factors for CDI increased the risk for HO-CDI (5,05; 95% Cl:
1.10-23.05; P 0,037), the median length of stay (LOS) attributable HO-CDI was 7 days (IQR,5-10) per admission,
whereas for non-CDI-HAD was 2 days (IQR,0-4) (p=0.036). General hospitalization costs in the two groups
were similar, specifically estimated costs attributable to HO-CDI and non-CID-HAD were $294.0 and $137.0 per
hospitalization respectively (p=<0.0001).
Conclusion. Although in children the incidence of HO-CDI is increasing, its clinical manifestation is still milder
and effective infection control measures with antibiotic stewardship can limit related morbidly, mortality, LOS,
and cost.
AU  - ÖCAL DEMİR, Sevliya
AU  - Akkoc, Gulsen
AU  - KEPENEKLİ, Eda
AU  - Yakut, Nurhayat
AU  - Soysal, Ahmet
DO  - 10.24953/turkjped.2021.06.008
PY  - 2021
JO  - Turkish Journal of Pediatrics
VL  - 63
IS  - 6
SN  - 0041-4301
SP  - 1004
EP  - 1011
DB  - TRDizin
UR  - http://search/yayin/detay/518294
ER  -